<cons sem="G#other_name">IL-2 gene expression</cons> and <cons sem="G#other_name"><cons sem="G#protein_molecule">NF-kappa B</cons> activation</cons> through <cons sem="G#protein_molecule">CD28</cons> requires reactive oxygen production by <cons sem="G#protein

1,5c1,3 < < < < --- > > > 8c6 < --- > 14c12,14 < <cons sem="G#other_name">IL-2 gene expression</cons> and <cons sem="G#other_name"><cons sem="G#protein_molecule">NF-kappa B</cons> activation</cons> through <cons sem="G#protein_molecule">CD28</cons> requires reactive oxygen production by <cons sem="G#protein_molecule">5-lipoxygenase</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">IL-2 gene</cons> expression</cons> and <cons sem="G#other_name"><cons sem="G#protein_molecule">NF-kappa B</cons> activation</cons> through <cons sem="G#protein_molecule">CD28</cons> requires reactive oxygen production by <cons sem="G#protein_molecule">5-lipoxygenase</cons>.</sentence> > 28c28,30 < The <cons sem="G#DNA_domain_or_region">peri-kappa B site</cons> mediates <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region"><cons sem="G#virus">human immunodeficiency virus type 2</cons> enhancer</cons> activation</cons> in <cons sem="G#cell_type">monocytes</cons> but not in <cons sem="G#cell_type">T cells</cons>. --- > > <sentence>The <cons sem="G#DNA_domain_or_region">peri-kappa B site</cons> mediates <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region"><cons sem="G#virus">human immunodeficiency virus type 2</cons> enhancer</cons> activation</cons> in <cons sem="G#cell_type">monocytes</cons> but not in <cons sem="G#cell_type">T cells</cons>.</sentence> > 47c49,51 < <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">E1A gene</cons> expression</cons> induces susceptibility to killing by <cons sem="G#cell_type">NK cells</cons> following immortalization but not <cons sem="G#other_name"><cons sem="G#virus">adenovirus</cons> infection</cons> of <cons sem="G#cell_type">human cells</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">E1A gene</cons> expression</cons> induces susceptibility to killing by <cons sem="G#cell_type">NK cells</cons> following immortalization but not <cons sem="G#other_name"><cons sem="G#virus">adenovirus</cons> infection</cons> of <cons sem="G#cell_type">human cells</cons>.</sentence> > 49c53 < Adenovirus (Ad) infection and E1A transfection were used to model changes in susceptibility to NK cell killing caused by transient vs stable E1A expression in human cells. --- > Adenovirus (Ad) infection and E1A transfection were used to model changes in susceptibility to NK cell killing caused by transient vs stable E1A expression in human cells. 52c56 < This differential effect of E1A expression on the cytolytic phenotypes of infected and stably transfected human cells suggests that human NK cells provide an effective immunologic barrier against the in vivo survival and neoplastic progression of E1A-immortalized cells that may emerge from the reservoir of persistently infected cells in the human host. --- > This differential effect of E1A expression on the cytolytic phenotypes of infected and stably transfected human cells suggests that human NK cells provide an effective immunologic barrier against the in vivo survival and neoplastic progression of E1A-immortalized cells that may emerge from the reservoir of persistently infected cells in the human host. 60c64,66 < Distinct signaling properties identify functionally different <cons sem="G#protein_family_or_group">CD4 epitopes</cons>. --- > > <sentence>Distinct signaling properties identify functionally different <cons sem="G#protein_family_or_group">CD4 epitopes</cons>.</sentence> > 63,65c69,71 < We have investigated the effect of CD4 triggering on T cell activating signals in a lymphoma model using monoclonal antibodies (mAb) which recognize different CD4 epitopes. < We demonstrate that CD4 triggering delivers signals capable of activating the NF-AT transcription factor which is required for interleukin-2 gene expression. < Whereas different anti-CD4 mAb or HIV-1 gp120 could all trigger activation of the protein tyrosine kinases p56lck and p59fyn and phosphorylation of the Shc adaptor protein, which mediates signals to Ras, they differed significantly in their ability to activate NF-AT. --- > We have investigated the effect of CD4 triggering on T cell activating signals in a lymphoma model using monoclonal antibodies (mAb) which recognize different CD4 epitopes. > We demonstrate that CD4 triggering delivers signals capable of activating the NF-AT transcription factor which is required for interleukin-2 gene expression. > Whereas different anti-CD4 mAb or HIV-1 gp120 could all trigger activation of the protein tyrosine kinases p56lck and p59fyn and phosphorylation of the Shc adaptor protein, which mediates signals to Ras, they differed significantly in their ability to activate NF-AT. 67c73 < The results identify functionally distinct epitopes on the CD4 coreceptor involved in activation of the Ras/protein kinase C and calcium pathways. --- > The results identify functionally distinct epitopes on the CD4 coreceptor involved in activation of the Ras/protein kinase C and calcium pathways. 75c81,83 < <cons sem="G#other_name">Ligand-dependent repression</cons> of the <cons sem="G#protein_family_or_group">erythroid transcription factor</cons> <cons sem="G#protein_molecule">GATA- 1</cons> by the <cons sem="G#protein_family_or_group">estrogen receptor</cons>. --- > > <sentence><cons sem="G#other_name">Ligand-dependent repression</cons> of the <cons sem="G#protein_family_or_group">erythroid transcription factor</cons> <cons sem="G#protein_molecule">GATA- 1</cons> by the <cons sem="G#protein_family_or_group">estrogen receptor</cons>.</sentence> > 96,97c104,107 < <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">Mouse <cons sem="G#protein_molecule">interleukin-2</cons> receptor alpha gene</cons> expression</cons>. < <cons sem="G#protein_molecule">Interleukin-1</cons> and <cons sem="G#protein_molecule">interleukin-2</cons> control transcription via distinct <cons sem="G#DNA_family_or_group">cis-acting elements</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">Mouse <cons sem="G#protein_molecule">interleukin-2</cons> receptor alpha gene</cons> expression</cons>. > <cons sem="G#protein_molecule">Interleukin-1</cons> and <cons sem="G#protein_molecule">interleukin-2</cons> control transcription via distinct <cons sem="G#DNA_family_or_group">cis-acting elements</cons>.</sentence> > 99c109 < We have shown that interleukin-1 (IL-1) and IL-2 control IL-2 receptor alpha (IL-2R alpha) gene transcription in CD4-CD8- murine T lymphocyte precursors. --- > We have shown that interleukin-1 (IL-1) and IL-2 control IL-2 receptor alpha (IL-2R alpha) gene transcription in CD4-CD8- murine T lymphocyte precursors. 116c126,128 < <cons sem="G#other_name"><cons sem="G#cell_type">Hematopoietic lineage</cons> commitment</cons>: role of <cons sem="G#protein_family_or_group">transcription factors</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#cell_type">Hematopoietic lineage</cons> commitment</cons>: role of <cons sem="G#protein_family_or_group">transcription factors</cons>.</sentence> > 129c141,143 < <cons sem="G#other_name"><cons sem="G#virus">Epstein-Barr virus</cons> replicative gene transcription</cons> during <cons sem="G#other_name">de novo infection</cons> of <cons sem="G#cell_type">human thymocytes</cons>: <cons sem="G#other_name">simultaneous early expression</cons> of <cons sem="G#protein_molecule">BZLF-1</cons> and its repressor <cons sem="G#protein_molecule">RAZ</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#virus">Epstein-Barr virus</cons> replicative gene transcription</cons> during <cons sem="G#other_name">de novo infection</cons> of <cons sem="G#cell_type">human thymocytes</cons>: <cons sem="G#other_name">simultaneous early expression</cons> of <cons sem="G#protein_molecule">BZLF-1</cons> and its repressor <cons sem="G#protein_molecule">RAZ</cons>.</sentence> > 151c165,167 < Identification and purification of <cons sem="G#protein_family_or_group">human Stat proteins</cons> activated in response to <cons sem="G#protein_molecule">interleukin-2</cons>. --- > > <sentence>Identification and purification of <cons sem="G#protein_family_or_group">human Stat proteins</cons> activated in response to <cons sem="G#protein_molecule">interleukin-2</cons>.</sentence> > 169c185,187 < <cons sem="G#protein_molecule">E2F-1</cons> and a <cons sem="G#protein_family_or_group">cyclin-like DNA repair enzyme</cons>, <cons sem="G#protein_molecule">uracil-DNA glycosylase</cons>, provide evidence for an <cons sem="G#other_name">autoregulatory mechanism for transcription</cons>. --- > > <sentence><cons sem="G#protein_molecule">E2F-1</cons> and a <cons sem="G#protein_family_or_group">cyclin-like DNA repair enzyme</cons>, <cons sem="G#protein_molecule">uracil-DNA glycosylase</cons>, provide evidence for an <cons sem="G#other_name">autoregulatory mechanism for transcription</cons>.</sentence> > 186c204,206 < <cons sem="(AND G#other_name G#other_name)"><cons>Cellular</cons> and <cons>molecular</cons> <cons>mechanisms</cons></cons> of <cons sem="G#other_name">IFN-gamma production</cons> induced by <cons sem="G#protein_molecule">IL- 2</cons> and <cons sem="G#protein_molecule">IL-12</cons> in a <cons sem="G#cell_line">human NK cell line</cons>. --- > > <sentence><cons sem="(AND G#other_name G#other_name)"><cons>Cellular</cons> and <cons>molecular</cons> <cons>mechanisms</cons></cons> of <cons sem="G#other_name"><cons sem="G#protein_molecule">IFN-gamma</cons> production</cons> induced by <cons sem="G#protein_molecule">IL- 2</cons> and <cons sem="G#protein_molecule">IL-12</cons> in a <cons sem="G#cell_line">human NK cell line</cons>.</sentence> > 197c217 < It also was observed that suppression of cytokine gene expression by these agents was independent of the inhibition of proliferation. --- > It also was observed that suppression of cytokine gene expression by these agents was independent of the inhibition of proliferation. 207c227,229 < A <cons sem="G#other_name">functional <cons sem="G#protein_family_or_group">T-cell receptor</cons> signaling pathway</cons> is required for <cons sem="G#other_name"><cons sem="G#protein_molecule">p95vav</cons> activity</cons>. --- > > <sentence>A <cons sem="G#other_name">functional <cons sem="G#protein_family_or_group">T-cell receptor</cons> signaling pathway</cons> is required for <cons sem="G#other_name"><cons sem="G#protein_molecule">p95vav</cons> activity</cons>.</sentence> > 217c239 < We further demonstrate that the p95vav-induced NFAT activation is not mimicked by Ras activation, though its function is dependent upon Ras and Raf. --- > We further demonstrate that the p95vav-induced NFAT activation is not mimicked by Ras activation, though its function is dependent upon Ras and Raf. 229c251,253 < <cons sem="(AND G#other_name G#other_name)"><cons>Positive</cons> and <cons>negative</cons> <cons>regulation</cons></cons> of <cons sem="G#other_name"><cons sem="G#protein_molecule">granulocyte-macrophage colony- stimulating factor</cons> promoter activity</cons> by <cons sem="G#protein_molecule">AML1-related transcription factor</cons>, <cons sem="G#protein_molecule">PEBP2</cons>. --- > > <sentence><cons sem="(AND G#other_name G#other_name)"><cons>Positive</cons> and <cons>negative</cons> <cons>regulation</cons></cons> of <cons sem="G#other_name"><cons sem="G#protein_molecule">granulocyte-macrophage colony- stimulating factor</cons> promoter activity</cons> by <cons sem="G#protein_molecule">AML1-related transcription factor</cons>, <cons sem="G#protein_molecule">PEBP2</cons>.</sentence> > 249c273,275 < <cons sem="G#protein_molecule">IFN-gamma</cons> priming of <cons sem="G#cell_type">monocytes</cons> enhances <cons sem="G#other_name"><cons sem="G#lipid">LPS</cons>-induced <cons sem="G#protein_family_or_group">TNF</cons> production</cons> by augmenting both <cons sem="G#other_name">transcription</cons> and <cons sem="G#other_name">MRNA stability</cons>. --- > > <sentence><cons sem="G#protein_molecule">IFN-gamma</cons> priming of <cons sem="G#cell_type">monocytes</cons> enhances <cons sem="G#other_name"><cons sem="G#lipid">LPS</cons>-induced <cons sem="G#protein_family_or_group">TNF</cons> production</cons> by augmenting both <cons sem="G#other_name">transcription</cons> and <cons sem="G#other_name">MRNA stability</cons>.</sentence> > 272c298,300 < A <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_family_or_group">Myc-associated zinc finger protein</cons> binding site</cons> is one of four important <cons sem="G#DNA_domain_or_region">functional regions</cons> in the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">CD4</cons> promoter</cons>. --- > > <sentence>A <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_family_or_group">Myc-associated zinc finger protein</cons> binding site</cons> is one of four important <cons sem="G#DNA_domain_or_region">functional regions</cons> in the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">CD4</cons> promoter</cons>.</sentence> > 288c316,318 < <cons sem="G#protein_molecule">Erythropoietin</cons> stimulates transcription of the <cons sem="G#DNA_domain_or_region">TAL1/SCL gene</cons> and <cons sem="G#other_name">phosphorylation</cons> of its <cons sem="G#protein_domain_or_region">protein products</cons>. --- > > <sentence><cons sem="G#protein_molecule">Erythropoietin</cons> stimulates transcription of the <cons sem="G#DNA_domain_or_region">TAL1/SCL gene</cons> and <cons sem="G#other_name">phosphorylation</cons> of its <cons sem="G#protein_domain_or_region">protein products</cons>.</sentence> > 305c335,337 < <cons sem="G#other_name">Nonradioactive quantification</cons> of <cons sem="G#other_name"><cons sem="G#protein_domain_or_region">glucocorticoid receptor</cons> expression</cons> during differentiation of human <cons sem="G#cell_type">monocytic cells</cons> (<cons sem="G#cell_line">U937</cons>). --- > > <sentence><cons sem="G#other_name">Nonradioactive quantification</cons> of <cons sem="G#other_name"><cons sem="G#protein_domain_or_region">glucocorticoid receptor</cons> expression</cons> during differentiation of human <cons sem="G#cell_type">monocytic cells</cons> (<cons sem="G#cell_line">U937</cons>).</sentence> > 318c350,352 < Induction of <cons sem="G#other_name"><cons sem="G#protein_molecule">Sp1</cons> <cons sem="G#other_name">phosphorylation</cons></cons> and <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">NF-kappa B</cons>-independent <cons sem="G#virus">HIV</cons> promoter</cons> domain activity</cons> in <cons sem="G#cell_type">T lymphocytes</cons> stimulated by <cons sem="G#other_organic_compound">okadaic acid</cons>. --- > > <sentence>Induction of <cons sem="G#other_name"><cons sem="G#protein_molecule">Sp1</cons> <cons sem="G#other_name">phosphorylation</cons></cons> and <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">NF-kappa B</cons>-independent <cons sem="G#virus">HIV</cons> promoter</cons> domain activity</cons> in <cons sem="G#cell_type">T lymphocytes</cons> stimulated by <cons sem="G#other_organic_compound">okadaic acid</cons>.</sentence> > 320c354 < In contrast to the purely enhancer-dependent effect of cytokines such as TNF on the activity of the HIV regulatory region (LTR), we observed that okadaic acid (OKA) activates HIV transcription through both the enhancer, responding to the factor NF-kappa B, and the promoter domain of the LTR. --- > In contrast to the purely enhancer-dependent effect of cytokines such as TNF on the activity of the HIV regulatory region (LTR), we observed that okadaic acid (OKA) activates HIV transcription through both the enhancer, responding to the factor NF-kappa B, and the promoter domain of the LTR. 333c367,369 < The role of <cons sem="G#protein_substructure">shared receptor motifs</cons> and <cons sem="G#protein_family_or_group">common Stat proteins</cons> in the generation of <cons sem="G#other_name"><cons sem="G#protein_family_or_group">cytokine</cons> pleiotropy</cons> and redundancy by <cons sem="G#protein_molecule">IL-2</cons>, <cons sem="G#protein_molecule">IL-4</cons>, <cons sem="G#protein_molecule">IL-7</cons>, <cons sem="G#protein_molecule">IL-13</cons>, and <cons sem="G#protein_molecule">IL-15</cons>. --- > > <sentence>The role of <cons sem="G#protein_substructure">shared receptor motifs</cons> and <cons sem="G#protein_family_or_group">common Stat proteins</cons> in the generation of <cons sem="G#other_name"><cons sem="G#protein_family_or_group">cytokine</cons> pleiotropy</cons> and redundancy by <cons sem="G#protein_molecule">IL-2</cons>, <cons sem="G#protein_molecule">IL-4</cons>, <cons sem="G#protein_molecule">IL-7</cons>, <cons sem="G#protein_molecule">IL-13</cons>, and <cons sem="G#protein_molecule">IL-15</cons>.</sentence> > 337c373 < IL-7 and IL-15 induced the same complexes as IL-2, a feature explained by the existence of similar tyrosine-phosphorylated motifs in the cytoplasmic domains of IL-2R beta and IL-7R that can serve as docking sites for Stat proteins. --- > IL-7 and IL-15 induced the same complexes as IL-2, a feature explained by the existence of similar tyrosine-phosphorylated motifs in the cytoplasmic domains of IL-2R beta and IL-7R that can serve as docking sites for Stat proteins. 347c383,385 < Control of <cons sem="G#other_name"><cons sem="G#protein_molecule">I kappa B-alpha</cons> proteolysis</cons> by site-specific, signal-induced <cons sem="G#other_name">phosphorylation</cons>. --- > > <sentence>Control of <cons sem="G#other_name"><cons sem="G#protein_molecule">I kappa B-alpha</cons> proteolysis</cons> by site-specific, signal-induced <cons sem="G#other_name">phosphorylation</cons>.</sentence> > 362c400,402 < Regulation of <cons sem="G#other_name">transcription</cons> of the <cons sem="G#DNA_domain_or_region">human erythropoietin receptor gene</cons> by proteins binding to <cons sem="G#DNA_domain_or_region"><cons sem="G#DNA_domain_or_region">GATA-1</cons> and <cons sem="G#DNA_domain_or_region">Sp1 motifs</cons></cons>. --- > > <sentence>Regulation of <cons sem="G#other_name">transcription</cons> of the <cons sem="G#DNA_domain_or_region">human erythropoietin receptor gene</cons> by proteins binding to <cons sem="G#DNA_domain_or_region"><cons sem="G#DNA_domain_or_region">GATA-1</cons> and <cons sem="G#DNA_domain_or_region">Sp1 motifs</cons></cons>.</sentence> > 381c421,423 < Overexpression of <cons sem="G#protein_molecule">DR-nm23</cons>, a protein encoded by a member of the <cons sem="G#DNA_family_or_group">nm23 gene family</cons>, inhibits <cons sem="G#other_name"><cons sem="G#cell_type">granulocyte</cons> differentiation</cons> and induces <cons sem="G#other_name">apoptosis</cons> in <cons sem="G#cell_line">32Dc13 myeloid cells</cons>. --- > > <sentence>Overexpression of <cons sem="G#protein_molecule">DR-nm23</cons>, a protein encoded by a member of the <cons sem="G#DNA_family_or_group">nm23 gene family</cons>, inhibits <cons sem="G#other_name"><cons sem="G#cell_type">granulocyte</cons> differentiation</cons> and induces <cons sem="G#other_name">apoptosis</cons> in <cons sem="G#cell_line">32Dc13 myeloid cells</cons>.</sentence> > 386c428 < The deduced amino acid sequence similarity to the proteins encoded by these two latter genes is approximately 65% and includes domains and amino acid residues (the leucine zipper-like and the RGD domain, a serine and a histidine residue in the NH2- and in the COOH- terminal portion of the protein, respectively) postulated to be important for nm23 function. --- > The deduced amino acid sequence similarity to the proteins encoded by these two latter genes is approximately 65% and includes domains and amino acid residues (the leucine zipper-like and the RGD domain, a serine and a histidine residue in the NH2- and in the COOH- terminal portion of the protein, respectively) postulated to be important for nm23 function. 397c439,441 < An i<cons sem="G#DNA_domain_or_region">nterferon-gamma activation sequence</cons> mediates the <cons sem="G#other_name">transcriptional regulation</cons> of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_family_or_group">IgG Fc receptor</cons> type IC gene</cons> by <cons sem="G#protein_molecule">interferon-gamma</cons>. --- > > <sentence>An <cons sem="G#DNA_domain_or_region">interferon-gamma activation sequence</cons> mediates the <cons sem="G#other_name">transcriptional regulation</cons> of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_family_or_group">IgG Fc receptor</cons> type IC gene</cons> by <cons sem="G#protein_molecule">interferon-gamma</cons>.</sentence> > 417c461,463 < Constitutively activated <cons sem="G#other_name">Jak-STAT pathway</cons> in <cons sem="G#cell_type">T cells</cons> transformed with <cons sem="G#virus">HTLV-I</cons>. --- > > <sentence>Constitutively activated <cons sem="G#other_name"><cons sem="G#protein_family_or_group">Jak</cons>-<cons sem="G#protein_family_or_group">STAT</cons> pathway</cons> in <cons sem="G#cell_type">T cells</cons> transformed with <cons sem="G#virus">HTLV-I</cons>.</sentence> > 422c468 < In HTLV-I- infected cord blood lymphocytes, the transition from IL-2-dependent to IL-2-independent growth correlated with the acquisition of a constitutively activated Jak-STAT pathway, which suggests that this pathway participates in HTLV-I-mediated T cell transformation. --- > In HTLV-I- infected cord blood lymphocytes, the transition from IL-2-dependent to IL-2-independent growth correlated with the acquisition of a constitutively activated Jak-STAT pathway, which suggests that this pathway participates in HTLV-I-mediated T cell transformation. 430,431c476,479 < <cons sem="G#inorganic">Nitric oxide</cons> decreases <cons sem="G#other_name">cytokine-induced endothelial activation</cons>. < <cons sem="G#inorganic">Nitric oxide</cons> selectively reduces <cons sem="G#other_name">endothelial expression</cons> of <cons sem="G#protein_family_or_group">adhesion molecules</cons> and <cons sem="G#protein_family_or_group">proinflammatory cytokines</cons>. --- > > <sentence><cons sem="G#inorganic">Nitric oxide</cons> decreases <cons sem="G#other_name"><cons sem="G#protein_family_or_group">cytokine</cons>-induced endothelial activation</cons>. > <cons sem="G#inorganic">Nitric oxide</cons> selectively reduces <cons sem="G#other_name">endothelial expression</cons> of <cons sem="G#protein_family_or_group">adhesion molecules</cons> and <cons sem="G#protein_family_or_group">proinflammatory cytokines</cons>.</sentence> > 433c481 < To test the hypothesis that nitric oxide (NO) limits endothelial activation, we treated cytokine-stimulated human saphenous vein endothelial cells with several NO donors and assessed their effects on the inducible expression of vascular cell adhesion molecule-1 (VCAM-1). --- > To test the hypothesis that nitric oxide (NO) limits endothelial activation, we treated cytokine-stimulated human saphenous vein endothelial cells with several NO donors and assessed their effects on the inducible expression of vascular cell adhesion molecule-1 (VCAM-1). 438c486 < Nuclear run-on assays, transfection studies using various VCAM-1 promoter reporter gene constructs, and electrophoretic mobility shift assays indicated that NO represses VCAM- 1 gene transcription, in part, by inhibiting NF-kappa B. --- > Nuclear run-on assays, transfection studies using various VCAM-1 promoter reporter gene constructs, and electrophoretic mobility shift assays indicated that NO represses VCAM- 1 gene transcription, in part, by inhibiting NF-kappa B. 447c495,497 < <cons sem="G#protein_molecule">MIP1 alpha nuclear protein</cons> (<cons sem="G#protein_molecule">MNP</cons>), a novel <cons sem="G#protein_family_or_group">transcription factor</cons> expressed in hematopoietic cells that is crucial for <cons sem="G#other_name">transcription</cons> of the <cons sem="G#DNA_domain_or_region">human MIP-1 alpha gene</cons>. --- > > <sentence><cons sem="G#protein_molecule">MIP1 alpha nuclear protein</cons> (<cons sem="G#protein_molecule">MNP</cons>), a novel <cons sem="G#protein_family_or_group">transcription factor</cons> expressed in hematopoietic cells that is crucial for <cons sem="G#other_name">transcription</cons> of the <cons sem="G#DNA_domain_or_region">human MIP-1 alpha gene</cons>.</sentence> > 468c518,520 < The effect of <cons sem="G#other_organic_compound">Toremifene</cons> on the expression of some genes in <cons sem="G#cell_type">human mononuclear cells</cons>. --- > > <sentence>The effect of <cons sem="G#other_organic_compound">Toremifene</cons> on the expression of some genes in <cons sem="G#cell_type">human mononuclear cells</cons>.</sentence> > 480c532,534 < The <cons sem="G#other_name"><cons sem="G#protein_family_or_group">interleukin-5</cons>/receptor interaction</cons> activates <cons sem="(AND G#protein_family_or_group G#protein_family_or_group)"><cons>Lyn</cons> and <cons>Jak2</cons> <cons>tyrosine kinases</cons></cons> and propagates signals via the <cons sem="G#protein_molecule">Ras-Raf-1-MAP kinase</cons> and the <cons sem="G#other_name">Jak- STAT pathways</cons> in <cons sem="G#cell_type">eosinophils</cons>. --- > > <sentence>The <cons sem="G#other_name"><cons sem="G#protein_family_or_group">interleukin-5</cons>/receptor interaction</cons> activates <cons sem="(AND G#protein_family_or_group G#protein_family_or_group)"><cons>Lyn</cons> and <cons>Jak2</cons> <cons>tyrosine kinases</cons></cons> and propagates signals via the <cons sem="G#protein_molecule">Ras-Raf-1-MAP kinase</cons> and the <cons sem="G#other_name"><cons sem="G#protein_family_or_group">Jak</cons>- <cons sem="G#protein_family_or_group">STAT</cons> pathways</cons> in <cons sem="G#cell_type">eosinophils</cons>.</sentence> > 496c550,552 < The <cons sem="G#protein_molecule">retinoblastoma gene product</cons> negatively regulates <cons sem="G#protein_N/A">transcriptional activation</cons> mediated by the <cons sem="G#protein_molecule"><cons sem="G#virus">human cytomegalovirus</cons> IE2 protein</cons>. --- > > <sentence>The <cons sem="G#protein_molecule">retinoblastoma gene product</cons> negatively regulates <cons sem="G#protein_N/A">transcriptional activation</cons> mediated by the <cons sem="G#protein_molecule"><cons sem="G#virus">human cytomegalovirus</cons> IE2 protein</cons>.</sentence> > 500c556 < We found that the retinoblastoma susceptibility gene product (Rb) dramatically suppressed this IE2 transactivation of various promoters. --- > We found that the retinoblastoma susceptibility gene product (Rb) dramatically suppressed this IE2 transactivation of various promoters. 512c568,570 < Expression of the <cons sem="G#protein_molecule">nucleoside diphosphate kinase</cons> in <cons sem="G#other_name">human skin cancers</cons>: an <cons sem="G#other_name">immunohistochemical study</cons>. --- > > <sentence>Expression of the <cons sem="G#protein_molecule">nucleoside diphosphate kinase</cons> in <cons sem="G#other_name">human skin cancers</cons>: an <cons sem="G#other_name">immunohistochemical study</cons>.</sentence> > 516c574 < In order to determine whether NDP kinase expression serves as a marker for metastatic potential in human skin cancer, we assessed the levels of NDP kinase expression in 9 keratoacanthomas (KAs), 26 squamous cell carcinomas (SCCs), and 25 basal cell carcinomas (BCCs) using immunohistochemistry. --- > In order to determine whether NDP kinase expression serves as a marker for metastatic potential in human skin cancer, we assessed the levels of NDP kinase expression in 9 keratoacanthomas (KAs), 26 squamous cell carcinomas (SCCs), and 25 basal cell carcinomas (BCCs) using immunohistochemistry. 529c587,589 < <cons sem="G#protein_molecule">RB</cons> and a novel <cons sem="G#protein_family_or_group">E2F-1 binding protein</cons> in <cons sem="G#cell_line">MHC class II deficient B-cell lines</cons> and normal <cons sem="G#other_name"><cons sem="G#protein_molecule">IFN-gamma</cons> induction</cons> of the <cons sem="G#DNA_domain_or_region">class IL transactivator</cons> <cons sem="G#DNA_domain_or_region">CIITA</cons> in <cons sem="G#cell_line">class II non-inducible <cons sem="G#protein_molecule">RB</cons>-defective tumor lines</cons>. --- > > <sentence><cons sem="G#protein_molecule">RB</cons> and a novel <cons sem="G#protein_family_or_group">E2F-1 binding protein</cons> in <cons sem="G#cell_line">MHC class II deficient B-cell lines</cons> and normal <cons sem="G#other_name"><cons sem="G#protein_molecule">IFN-gamma</cons> induction</cons> of the <cons sem="G#DNA_domain_or_region">class IL transactivator</cons> <cons sem="G#DNA_domain_or_region">CIITA</cons> in <cons sem="G#cell_line">class II non-inducible <cons sem="G#protein_molecule">RB</cons>-defective tumor lines</cons>.</sentence> > 549c609,611 < <cons sem="G#protein_molecule">Interleukin 12</cons> induces <cons sem="G#other_name"><cons sem="G#amino_acid_monomer">tyrosine</cons> phosphorylation</cons> and activation of <cons sem="G#protein_molecule">STAT4</cons> in <cons sem="G#cell_type">human lymphocytes</cons>. --- > > <sentence><cons sem="G#protein_molecule">Interleukin 12</cons> induces <cons sem="G#other_name"><cons sem="G#amino_acid_monomer">tyrosine</cons> phosphorylation</cons> and activation of <cons sem="G#protein_molecule">STAT4</cons> in <cons sem="G#cell_type">human lymphocytes</cons>.</sentence> > 556c618 < These data, and the recent demonstration of JAK phosphorylation by IL-12, identify a rapid signal-transduction pathway likely to mediate IL-12- induced gene expression. --- > These data, and the recent demonstration of JAK phosphorylation by IL-12, identify a rapid signal-transduction pathway likely to mediate IL-12- induced gene expression. 564c626,628 < Temperature-induced down-regulation of the <cons sem="G#protein_family_or_group">glucocorticoid receptor</cons> in <cons sem="G#cell_type">peripheral blood mononuclear leucocyte</cons> in <cons sem="G#multi_cell">patients</cons> with <cons sem="G#other_name">sepsis</cons> or <cons sem="G#other_name">septic shock</cons>. --- > > <sentence>Temperature-induced down-regulation of the <cons sem="G#protein_family_or_group">glucocorticoid receptor</cons> in <cons sem="G#cell_type">peripheral blood mononuclear leucocyte</cons> in <cons sem="G#multi_cell">patients</cons> with <cons sem="G#other_name">sepsis</cons> or <cons sem="G#other_name">septic shock</cons>.</sentence> > 587,588c651,654 < Integrin-mediated <cons sem="G#other_name"><cons sem="G#amino_acid_monomer">tyrosine</cons> phosphorylation</cons> and <cons sem="G#other_name">cytokine message induction</cons> in <cons sem="G#cell_type">monocytic cells</cons>. < A possible signaling role for the <cons sem="G#protein_family_or_group">Syk <cons sem="G#amino_acid_monomer">tyrosine</cons> kinase</cons>. --- > > <sentence>Integrin-mediated <cons sem="G#other_name"><cons sem="G#amino_acid_monomer">tyrosine</cons> phosphorylation</cons> and <cons sem="G#other_name"><cons sem="G#protein_family_or_group">cytokine</cons> message induction</cons> in <cons sem="G#cell_type">monocytic cells</cons>.</sentence> > <sentence>A possible signaling role for the <cons sem="G#protein_family_or_group">Syk <cons sem="G#amino_acid_monomer">tyrosine</cons> kinase</cons>.</sentence> > 597c663 < These observations indicate that the Syk tyrosine kinase may be an important component of an integrin signaling pathway in monocytic cells, leading to activation of NF-kappa B and to increased levels of cytokine messages. --- > These observations indicate that the Syk tyrosine kinase may be an important component of an integrin signaling pathway in monocytic cells, leading to activation of NF-kappa B and to increased levels of cytokine messages. 605c671,673 < Inhibition of <cons sem="G#lipid">dexamethasone</cons> binding to <cons sem="G#protein_family_or_group">human glucocorticoid receptor</cons> by <cons sem="G#cell_component"><cons sem="G#multi_cell">New World primate</cons> cell extracts</cons>. --- > > <sentence>Inhibition of <cons sem="G#lipid">dexamethasone</cons> binding to <cons sem="G#protein_family_or_group">human glucocorticoid receptor</cons> by <cons sem="G#cell_component"><cons sem="G#multi_cell">New World primate</cons> cell extracts</cons>.</sentence> > 621c689,691 < Disruption of a <cons sem="G#DNA_domain_or_region">GATA motif</cons> in the <cons sem="G#DNA_domain_or_region">Duffy gene promoter</cons> abolishes <cons sem="G#other_name">erythroid gene expression</cons> in <cons sem="G#multi_cell">Duffy-negative individuals</cons>. --- > > <sentence>Disruption of a <cons sem="G#DNA_domain_or_region">GATA motif</cons> in the <cons sem="G#DNA_domain_or_region">Duffy gene promoter</cons> abolishes <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">erythroid gene</cons> expression</cons> in <cons sem="G#multi_cell">Duffy-negative individuals</cons>.</sentence> > 634c704,706 < Activation of <cons sem="G#protein_molecule">pp90rsk</cons> and <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">early growth response-1 gene</cons> expression</cons> by <cons sem="G#protein_molecule">pokeweed mitogen</cons> in <cons sem="G#cell_type">human B cells</cons>. --- > > <sentence>Activation of <cons sem="G#protein_molecule">pp90rsk</cons> and <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">early growth response-1 gene</cons> expression</cons> by <cons sem="G#protein_molecule">pokeweed mitogen</cons> in <cons sem="G#cell_type">human B cells</cons>.</sentence> > 648c720,722 < A <cons sem="G#DNA_domain_or_region">conserved motif</cons> in the <cons sem="G#DNA_family_or_group">promoters</cons> of several <cons sem="G#protein_family_or_group">cytokines</cons> expressed by <cons sem="G#cell_line">human Th2-type lymphocytes</cons>. --- > > <sentence>A <cons sem="G#DNA_domain_or_region">conserved motif</cons> in the <cons sem="G#DNA_family_or_group">promoters</cons> of several <cons sem="G#protein_family_or_group">cytokines</cons> expressed by <cons sem="G#cell_line">human Th2-type lymphocytes</cons>.</sentence> > 664c738,740 < <cons sem="G#other_name"><cons sem="G#DNA_family_or_group">cDNA</cons> cloning</cons> of a <cons sem="G#protein_family_or_group">NGFI-B/nur77-related transcription factor</cons> from an <cons sem="G#cell_line">apoptotic human T cell line</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#DNA_family_or_group">cDNA</cons> cloning</cons> of a <cons sem="G#protein_family_or_group">NGFI-B/nur77-related transcription factor</cons> from an <cons sem="G#cell_line">apoptotic human T cell line</cons>.</sentence> > 679c755,757 < <cons sem="G#other_organic_compound">Aspirin</cons> inhibits <cons sem="G#other_name"><cons sem="G#protein_molecule">nuclear factor-kappa B</cons> mobilization</cons> and <cons sem="G#other_name">monocyte adhesion</cons> in <cons sem="G#cell_line">stimulated human endothelial cells</cons>. --- > > <sentence><cons sem="G#other_organic_compound">Aspirin</cons> inhibits <cons sem="G#other_name"><cons sem="G#protein_molecule">nuclear factor-kappa B</cons> mobilization</cons> and <cons sem="G#other_name">monocyte adhesion</cons> in <cons sem="G#cell_line">stimulated human endothelial cells</cons>.</sentence> > 687c765 < These effects of aspirin were not related to the inhibition of cyclooxygenase activity, since indomethacin was ineffective. --- > These effects of aspirin were not related to the inhibition of cyclooxygenase activity, since indomethacin was ineffective. 696c774,776 < Activation of <cons sem="G#protein_molecule">NF-kappa B</cons> by <cons sem="G#other_name">phosphatase inhibitors</cons> involves the <cons sem="G#other_name">phosphorylation</cons> of <cons sem="G#protein_molecule">I kappa B alpha</cons> at <cons sem="G#protein_domain_or_region">phosphatase 2A-sensitive sites</cons>. --- > > <sentence>Activation of <cons sem="G#protein_molecule">NF-kappa B</cons> by <cons sem="G#other_name"><cons sem="G#protein_family_or_group">phosphatase</cons> inhibitors</cons> involves the <cons sem="G#other_name">phosphorylation</cons> of <cons sem="G#protein_molecule">I kappa B alpha</cons> at <cons sem="G#protein_domain_or_region">phosphatase 2A-sensitive sites</cons>.</sentence> > 705c785 < Together, these results suggest that phosphorylation of I kappa B alpha, mediated through both the TNF-alpha- inducible and the PP-2A-opposing kinases, may serve to target I kappa B alpha for proteasome-mediated degradation. --- > Together, these results suggest that phosphorylation of I kappa B alpha, mediated through both the TNF-alpha- inducible and the PP-2A-opposing kinases, may serve to target I kappa B alpha for proteasome-mediated degradation. 713c793,795 < <cons sem="G#other_name"><cons sem="G#protein_molecule">Sp1</cons> functions</cons> in a <cons sem="G#other_name">chromatin-dependent manner</cons> to augment <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">human alpha- globin promoter</cons> activity</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#protein_molecule">Sp1</cons> functions</cons> in a <cons sem="G#other_name"><cons sem="G#DNA_family_or_group">chromatin</cons>-dependent manner</cons> to augment <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">human alpha- globin promoter</cons> activity</cons>.</sentence> > 729c811,813 < Costimulation of <cons sem="G#cell_line">human CD4+ T cells</cons> with <cons sem="G#protein_molecule">LFA-3</cons> and <cons sem="G#protein_molecule">B7</cons> induce distinct effects on <cons sem="G#protein_N/A">AP-1</cons> and <cons sem="G#protein_molecule">NF-kappa B</cons> <cons sem="G#protein_family_or_group">transcription factors</cons>. --- > > <sentence>Costimulation of <cons sem="G#cell_line">human CD4+ T cells</cons> with <cons sem="G#protein_molecule">LFA-3</cons> and <cons sem="G#protein_molecule">B7</cons> induce distinct effects on <cons sem="G#protein_N/A">AP-1</cons> and <cons sem="G#protein_molecule">NF-kappa B</cons> <cons sem="G#protein_family_or_group">transcription factors</cons>.</sentence> > 749c833,835 < The <cons sem="G#protein_molecule">Ah receptor</cons> recognizes <cons sem="G#DNA_domain_or_region">DNA binding sites</cons> for the <cons sem="G#protein_family_or_group">B cell <cons sem="G#protein_family_or_group">transcription factor</cons></cons>, <cons sem="G#protein_molecule">BSAP</cons>: a possible mechanism for <cons sem="G#other_name">dioxin-mediated alteration</cons> of <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">CD19 gene</cons> expression</cons> in <cons sem="G#cell_type">human B lymphocytes</cons>. --- > > <sentence>The <cons sem="G#protein_molecule">Ah receptor</cons> recognizes <cons sem="G#DNA_domain_or_region">DNA binding sites</cons> for the <cons sem="G#protein_family_or_group">B cell <cons sem="G#protein_family_or_group">transcription factor</cons></cons>, <cons sem="G#protein_molecule">BSAP</cons>: a possible mechanism for <cons sem="G#other_name">dioxin-mediated alteration</cons> of <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">CD19 gene</cons> expression</cons> in <cons sem="G#cell_type">human B lymphocytes</cons>.</sentence> > 764c850,852 < <cons sem="G#other_name">Inhibitory action</cons> of <cons sem="G#protein_family_or_group">nm23 proteins</cons> on induction of <cons sem="G#other_name">erythroid differentiation</cons> of <cons sem="G#cell_type">human leukemia cells</cons>. --- > > <sentence><cons sem="G#other_name">Inhibitory action</cons> of <cons sem="G#protein_family_or_group">nm23 proteins</cons> on induction of <cons sem="G#other_name">erythroid differentiation</cons> of <cons sem="G#cell_type">human leukemia cells</cons>.</sentence> > 771,772c859,860 < The erythroid differentiation of HEL cells was inhibited by recombinant human nm23-H1, -H2, mouse nm23-M1, and -M2 proteins. < Moreover, both the mutant nm23-H2His protein and truncated nm23-H2 protein containing N- terminal (1-60) peptide, which do not have NDP kinase activity, also inhibited erythroid differentiation of HEL cells. --- > The erythroid differentiation of HEL cells was inhibited by recombinant human nm23-H1, -H2, mouse nm23-M1, and -M2 proteins. > Moreover, both the mutant nm23-H2His protein and truncated nm23-H2 protein containing N- terminal (1-60) peptide, which do not have NDP kinase activity, also inhibited erythroid differentiation of HEL cells. 781c869,871 < <cons sem="G#other_name"><cons sem="G#lipid">Lipopolysaccharide</cons>-induced <cons sem="G#protein_molecule">E-selectin</cons> expression</cons> requires continuous presence of <cons sem="G#lipid">LPS</cons> and is inhibited by <cons sem="G#protein_family_or_group">bactericidal/permeability- increasing protein</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#lipid">Lipopolysaccharide</cons>-induced <cons sem="G#protein_molecule">E-selectin</cons> expression</cons> requires continuous presence of <cons sem="G#lipid">LPS</cons> and is inhibited by <cons sem="G#protein_family_or_group">bactericidal/permeability- increasing protein</cons>.</sentence> > 796c886,888 < <cons sem="G#protein_molecule">GM-CSF</cons> and <cons sem="G#protein_molecule">IL-2</cons> share common <cons sem="G#other_name">control mechanisms</cons> in response to <cons sem="G#other_name">costimulatory signals</cons> in <cons sem="G#cell_type">T cells</cons>. --- > > <sentence><cons sem="G#protein_molecule">GM-CSF</cons> and <cons sem="G#protein_molecule">IL-2</cons> share common <cons sem="G#other_name">control mechanisms</cons> in response to <cons sem="G#other_name">costimulatory signals</cons> in <cons sem="G#cell_type">T cells</cons>.</sentence> > 819c911,913 < <cons sem="G#other_organic_compound">Danazol</cons> decreases transcription of <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_family_or_group">estrogen receptor</cons> gene</cons> in <cons sem="G#cell_type">human monocytes</cons>. --- > > <sentence><cons sem="G#other_organic_compound">Danazol</cons> decreases transcription of <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_family_or_group">estrogen receptor</cons> gene</cons> in <cons sem="G#cell_type">human monocytes</cons>.</sentence> > 832c926,928 < Functional characterization of novel <cons sem="G#other_name"><cons sem="G#protein_molecule">IL-2</cons> transcriptional inhibitors</cons>. --- > > <sentence>Functional characterization of novel <cons sem="G#other_name"><cons sem="G#protein_molecule">IL-2</cons> transcriptional inhibitors</cons>.</sentence> > 853c949,951 < <cons sem="G#other_name">Transcriptional regulation</cons> of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_subunit">vacuolar H(+)-ATPase B2 subunit</cons> gene</cons> in <cons sem="G#cell_line">differentiating THP-1 cells</cons>. --- > > <sentence><cons sem="G#other_name">Transcriptional regulation</cons> of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_subunit">vacuolar H(+)-ATPase B2 subunit</cons> gene</cons> in <cons sem="G#cell_line">differentiating THP-1 cells</cons>.</sentence> > 856c954 < We examined mRNA levels of various V-ATPase subunits during differentiation of both native monocytes and the cell line THP-1, and found that transcriptional and post-transcriptional mechanisms could account for increases in cell V-ATPase content. --- > We examined mRNA levels of various V-ATPase subunits during differentiation of both native monocytes and the cell line THP-1, and found that transcriptional and post-transcriptional mechanisms could account for increases in cell V-ATPase content. 871c969,971 < Synergy between <cons sem="G#other_name">signal transduction pathways</cons> is obligatory for expression of <cons sem="G#DNA_domain_or_region">c-fos</cons> in <cons sem="(AND G#cell_line G#cell_line)"><cons>B</cons> and <cons>T</cons> <cons>cell lines</cons></cons>: implication for <cons sem="G#DNA_domain_or_region">c-fos</cons> control via <cons sem="G#protein_family_or_group">surface immunoglobulin</cons> and <cons sem="G#protein_family_or_group">T cell antigen receptors</cons>. --- > > <sentence>Synergy between <cons sem="G#other_name">signal transduction pathways</cons> is obligatory for expression of <cons sem="G#DNA_domain_or_region">c-fos</cons> in <cons sem="(AND G#cell_line G#cell_line)"><cons>B</cons> and <cons>T</cons> <cons>cell lines</cons></cons>: implication for <cons sem="G#DNA_domain_or_region">c-fos</cons> control via <cons sem="G#protein_family_or_group">surface immunoglobulin</cons> and <cons sem="G#protein_family_or_group">T cell antigen receptors</cons>.</sentence> > 882c982 < Signaling in B cells due to anti-Ig stimulation involves both kinase C activation and release of intracellular calcium, and results in c-fos mRNA induction. --- > Signaling in B cells due to anti-Ig stimulation involves both kinase C activation and release of intracellular calcium, and results in c-fos mRNA induction. 884c984 < That synergy of signaling pathways is relevant for the anti-Ig induction of c-fos is supported by the fact that cAMP-inducing agents and okadaic acid further enhance anti-Ig induction of c-fos. --- > That synergy of signaling pathways is relevant for the anti-Ig induction of c-fos is supported by the fact that cAMP-inducing agents and okadaic acid further enhance anti-Ig induction of c-fos. 893c993,995 < Multiple signals are required for function of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">human granulocyte- macrophage colony-stimulating factor</cons> gene promoter</cons> in <cons sem="G#cell_type">T cells</cons>. --- > > <sentence>Multiple signals are required for function of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">human granulocyte- macrophage colony-stimulating factor</cons> gene promoter</cons> in <cons sem="G#cell_type">T cells</cons>.</sentence> > 913c1015,1017 < IL-10 induces the <cons sem="G#other_name"><cons sem="G#amino_acid_monomer">tyrosine</cons> phosphorylation</cons> of <cons sem="G#protein_molecule">tyk2</cons> and <cons sem="G#protein_molecule">Jak1</cons> and the differential assembly of <cons sem="G#protein_molecule">STAT1 alpha</cons> and <cons sem="G#protein_complex">STAT3 complexes</cons> in <cons sem="G#cell_type">human T cells</cons> and <cons sem="G#cell_type">monocytes</cons>. --- > > <sentence>IL-10 induces the <cons sem="G#other_name"><cons sem="G#amino_acid_monomer">tyrosine</cons> phosphorylation</cons> of <cons sem="G#protein_molecule">tyk2</cons> and <cons sem="G#protein_molecule">Jak1</cons> and the differential assembly of <cons sem="G#protein_molecule">STAT1 alpha</cons> and <cons sem="G#protein_complex">STAT3 complexes</cons> in <cons sem="G#cell_type">human T cells</cons> and <cons sem="G#cell_type">monocytes</cons>.</sentence> > 927c1031,1033 < Use of new <cons sem="G#other_name">biologic markers</cons> in the <cons sem="G#other_name">ovulation induction</cons>. --- > > <sentence>Use of new <cons sem="G#other_name">biologic markers</cons> in the <cons sem="G#other_name">ovulation induction</cons>.</sentence> > 941c1047,1049 < Abnormal regulation of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">IL-2</cons> promoter</cons> in lpr <cons sem="G#cell_line">CD4-CD8- T lymphocytes</cons> results in <cons sem="G#other_name">constitutive expression</cons> of a <cons sem="G#protein_family_or_group">novel <cons sem="G#protein_family_or_group">nuclear factor of activated <cons sem="G#cell_type">T cells</cons></cons>-binding factor</cons>. --- > > <sentence>Abnormal regulation of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">IL-2</cons> promoter</cons> in lpr <cons sem="G#cell_line">CD4-CD8- T lymphocytes</cons> results in <cons sem="G#other_name">constitutive expression</cons> of a <cons sem="G#protein_family_or_group">novel <cons sem="G#protein_family_or_group">nuclear factor of activated <cons sem="G#cell_type">T cells</cons></cons>-binding factor</cons>.</sentence> > 944c1052 < Yet these same cells do initiate early TCR-mediated signaling events, such as generation of inositol phosphates and increased intracellular calcium. --- > Yet these same cells do initiate early TCR-mediated signaling events, such as generation of inositol phosphates and increased intracellular calcium. 961c1069,1071 < Cross-linking of <cons sem="G#protein_molecule">CD30</cons> induces <cons sem="G#other_name"><cons sem="G#virus">HIV</cons> expression</cons> in chronically infected <cons sem="G#cell_type">T cells</cons>. --- > > <sentence>Cross-linking of <cons sem="G#protein_molecule">CD30</cons> induces <cons sem="G#other_name"><cons sem="G#virus">HIV</cons> expression</cons> in chronically infected <cons sem="G#cell_type">T cells</cons>.</sentence> > 964c1074 < We demonstrate that cross-linking CD30 with an anti-CD30- specific monoclonal antibody, which mimics the described biological activities of the CD30 ligand (CD30L), results in HIV expression. --- > We demonstrate that cross-linking CD30 with an anti-CD30- specific monoclonal antibody, which mimics the described biological activities of the CD30 ligand (CD30L), results in HIV expression. 976c1086,1088 < <cons sem="G#other_name">Human <cons sem="G#DNA_family_or_group">MHC class II gene</cons> transcription</cons> directed by the <cons sem="G#protein_domain_or_region">carboxyl terminus</cons> of <cons sem="G#DNA_domain_or_region">CIITA</cons>, one of the <cons sem="G#DNA_family_or_group">defective genes</cons> in type <cons sem="G#other_name">II MHC combined immune deficiency</cons>. --- > > <sentence><cons sem="G#other_name">Human <cons sem="G#DNA_family_or_group">MHC class II gene</cons> transcription</cons> directed by the <cons sem="G#protein_domain_or_region">carboxyl terminus</cons> of <cons sem="G#DNA_domain_or_region">CIITA</cons>, one of the <cons sem="G#DNA_family_or_group">defective genes</cons> in type <cons sem="G#other_name">II <cons sem="G#protein_complex">MHC</cons> combined immune deficiency</cons>.</sentence> > 978c1090 < Type II major histocompatibility complex combined immune deficiency (type II MHC CID or bare lymphocyte syndrome) is a congenital immunodeficiency disease characterized by absent MHC class II expression. --- > Type II major histocompatibility complex combined immune deficiency (type II MHC CID or bare lymphocyte syndrome) is a congenital immunodeficiency disease characterized by absent MHC class II expression. 980c1092 < Recently, the defective gene in group II type II MHC CID has been isolated and termed CIITA. --- > Recently, the defective gene in group II type II MHC CID has been isolated and termed CIITA. 993,994c1105,1108 < Monocyte tethering by <cons sem="G#protein_molecule">P-selectin</cons> regulates <cons sem="G#protein_molecule">monocyte chemotactic protein- 1</cons> and <cons sem="G#other_name">tumor necrosis factor-alpha secretion</cons>. < <cons sem="G#other_name">Signal integration</cons> and <cons sem="G#other_name"><cons sem="G#protein_molecule">NF- kappa B</cons> translocation</cons> [see comments] --- > > <sentence>Monocyte tethering by <cons sem="G#protein_molecule">P-selectin</cons> regulates <cons sem="G#protein_molecule">monocyte chemotactic protein- 1</cons> and <cons sem="G#other_name"><cons sem="G#protein_molecule">tumor necrosis factor-alpha</cons> secretion</cons>. > <cons sem="G#other_name">Signal integration</cons> and <cons sem="G#other_name"><cons sem="G#protein_molecule">NF- kappa B</cons> translocation</cons> [see comments]</sentence> > 1008,1009c1122,1125 < Functional roles of <cons sem="G#DNA_family_or_group">in vivo footprinted DNA motifs</cons> within an <cons sem="G#DNA_domain_or_region">alpha- globin enhancer</cons>. < <cons sem="G#other_name">Erythroid lineage</cons> and developmental stage specificities. --- > > <sentence>Functional roles of <cons sem="G#DNA_family_or_group">in vivo footprinted DNA motifs</cons> within an <cons sem="G#DNA_domain_or_region">alpha- globin enhancer</cons>. > <cons sem="G#other_name">Erythroid lineage</cons> and developmental stage specificities.</sentence> > 1014c1130 < Three of these HS-40 enhancer motifs, 5'NF-E2/AP1, GT II, and GATA-1(c), positively regulate the zeta 2-globin promoter activity in embryonic/fetal erythroid K562 cells and the adult alpha-globin promoter activity in adult erythroid MEL cells. --- > Three of these HS-40 enhancer motifs, 5'NF-E2/AP1, GT II, and GATA-1(c), positively regulate the zeta 2-globin promoter activity in embryonic/fetal erythroid K562 cells and the adult alpha-globin promoter activity in adult erythroid MEL cells. 1026c1142,1144 < <cons sem="G#other_name"><cons sem="G#inorganic">Nitric oxide</cons>-stimulated <cons sem="G#nucleotide">guanine nucleotide</cons> exchange</cons> on <cons sem="G#protein_molecule">p21ras</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#inorganic">Nitric oxide</cons>-stimulated <cons sem="G#nucleotide">guanine nucleotide</cons> exchange</cons> on <cons sem="G#protein_molecule">p21ras</cons>.</sentence> > 1043c1161,1163 < <cons sem="G#other_name">Interleukin-2 promoter activity</cons> in <cons sem="G#cell_line"><cons sem="G#virus">Epstein-Barr virus</cons>-transformed B lymphocytes</cons> is controlled by <cons sem="G#protein_molecule">nuclear factor-chi B</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">Interleukin-2 promoter</cons> activity</cons> in <cons sem="G#cell_line"><cons sem="G#virus">Epstein-Barr virus</cons>-transformed B lymphocytes</cons> is controlled by <cons sem="G#protein_molecule">nuclear factor-chi B</cons>.</sentence> > 1054c1174 < A weaker chi B complex formation and faster-migrating complexes were detected in non-IL-2-secreting cells. --- > A weaker chi B complex formation and faster-migrating complexes were detected in non-IL-2-secreting cells. 1063c1183,1185 < <cons sem="G#protein_molecule">Latent membrane protein-1</cons> induces <cons sem="G#other_name"><cons sem="G#protein_molecule">cyclin D2</cons> expression</cons>, <cons sem="G#other_name">pRb hyperphosphorylation</cons>, and loss of <cons sem="G#other_name"><cons sem="G#protein_molecule">TGF-beta 1</cons>-mediated growth inhibition</cons> in <cons sem="G#cell_type">EBV-positive <cons sem="G#cell_type">B cells</cons></cons>. --- > > <sentence><cons sem="G#protein_molecule">Latent membrane protein-1</cons> induces <cons sem="G#other_name"><cons sem="G#protein_molecule">cyclin D2</cons> expression</cons>, <cons sem="G#other_name"><cons sem="G#protein_molecule">pRb</cons> hyperphosphorylation</cons>, and loss of <cons sem="G#other_name"><cons sem="G#protein_molecule">TGF-beta 1</cons>-mediated growth inhibition</cons> in <cons sem="G#cell_type">EBV-positive <cons sem="G#cell_type">B cells</cons></cons>.</sentence> > 1079c1201,1203 < Does <cons sem="G#other_name">thyroidectomy</cons>, <cons sem="G#other_name">radioactive <cons sem="G#atom">iodine</cons> therapy</cons>, or <cons sem="G#other_name">antithyroid drug treatment</cons> alter reactivity of patients' <cons sem="G#cell_type">T cells</cons> to <cons sem="G#other_name">epitopes</cons> of <cons sem="G#protein_family_or_group">thyrotropin receptor</cons> in <cons sem="G#other_name">autoimmune thyroid diseases</cons>? --- > > <sentence>Does <cons sem="G#other_name">thyroidectomy</cons>, <cons sem="G#other_name">radioactive <cons sem="G#atom">iodine</cons> therapy</cons>, or <cons sem="G#other_name">antithyroid drug treatment</cons> alter reactivity of patients' <cons sem="G#cell_type">T cells</cons> to <cons sem="G#other_name">epitopes</cons> of <cons sem="G#protein_family_or_group">thyrotropin receptor</cons> in <cons sem="G#other_name">autoimmune thyroid diseases</cons>?</sentence> > 1104c1228,1230 < Circumvention of tolerance for the <cons sem="G#protein_family_or_group">nuclear T cell protein</cons> <cons sem="G#protein_molecule">TCF-1</cons> by immunization of <cons sem="G#other_artificial_source"><cons sem="G#protein_molecule">TCF-1</cons> knock-out mice</cons>. --- > > <sentence>Circumvention of tolerance for the <cons sem="G#protein_family_or_group">nuclear T cell protein</cons> <cons sem="G#protein_molecule">TCF-1</cons> by immunization of <cons sem="G#other_artificial_source"><cons sem="G#protein_molecule">TCF-1</cons> knock-out mice</cons>.</sentence> > 1124c1250,1252 < The <cons sem="G#protein_family_or_group">transcription factor</cons>, <cons sem="G#protein_molecule">Nm23H2</cons>, binds to and activates the translocated <cons sem="G#DNA_domain_or_region">c-myc allele</cons> in <cons sem="G#other_name">Burkitt's lymphoma</cons>. --- > > <sentence>The <cons sem="G#protein_family_or_group">transcription factor</cons>, <cons sem="G#protein_molecule">Nm23H2</cons>, binds to and activates the translocated <cons sem="G#DNA_domain_or_region">c-myc allele</cons> in <cons sem="G#other_name">Burkitt's lymphoma</cons>.</sentence> > 1138c1266,1268 < Identification of two novel <cons sem="G#DNA_family_or_group">regulatory elements</cons> within the <cons sem="G#DNA_domain_or_region">5'- untranslated region</cons> of the <cons sem="G#DNA_domain_or_region">human A gamma-globin gene</cons>. --- > > <sentence>Identification of two novel <cons sem="G#DNA_family_or_group">regulatory elements</cons> within the <cons sem="G#DNA_domain_or_region">5'- untranslated region</cons> of the <cons sem="G#DNA_domain_or_region">human A gamma-globin gene</cons>.</sentence> > 1157c1287,1289 < Coupling of a <cons sem="G#protein_domain_or_region">signal response domain</cons> in <cons sem="G#protein_molecule">I kappa B alpha</cons> to <cons sem="G#other_name">multiple pathways</cons> for <cons sem="G#other_name"><cons sem="G#protein_molecule">NF-kappa B</cons> activation</cons>. --- > > <sentence>Coupling of a <cons sem="G#protein_domain_or_region">signal response domain</cons> in <cons sem="G#protein_molecule">I kappa B alpha</cons> to <cons sem="G#other_name">multiple pathways</cons> for <cons sem="G#other_name"><cons sem="G#protein_molecule">NF-kappa B</cons> activation</cons>.</sentence> > 1175c1307,1309 < <cons sem="G#other_name">Growth regulation</cons> and <cons sem="G#other_name">cellular changes</cons> during differentiation of <cons sem="G#cell_line">human <cons sem="G#other_name">prostatic cancer</cons> <cons sem="G#cell_line">LNCaP cells</cons></cons> as induced by <cons sem="G#other_organic_compound">T lymphocyte-conditioned medium</cons>. --- > > <sentence><cons sem="G#other_name">Growth regulation</cons> and <cons sem="G#other_name">cellular changes</cons> during differentiation of <cons sem="G#cell_line">human <cons sem="G#other_name">prostatic cancer</cons> <cons sem="G#cell_line">LNCaP cells</cons></cons> as induced by <cons sem="G#other_organic_compound">T lymphocyte-conditioned medium</cons>.</sentence> > 1198,1199c1332,1335 < <cons sem="G#protein_family_or_group">Platelet-activating factor</cons> stimulates transcription of the <cons sem="G#protein_molecule">heparin- binding epidermal growth factor-like growth factor</cons> in <cons sem="G#cell_type">monocytes</cons>. < Correlation with an increased <cons sem="G#other_name">kappa B binding activity</cons>. --- > > <sentence><cons sem="G#protein_family_or_group">Platelet-activating factor</cons> stimulates transcription of the <cons sem="G#protein_molecule">heparin- binding epidermal growth factor-like growth factor</cons> in <cons sem="G#cell_type">monocytes</cons>.</sentence> > <sentence>Correlation with an increased <cons sem="G#other_name">kappa B binding activity</cons>.</sentence> > 1216c1352,1354 < Mapping of the <cons sem="G#protein_domain_or_region">interaction site</cons> of the <cons sem="G#protein_family_or_group">defective <cons sem="G#protein_family_or_group">transcription factor</cons></cons> in the <cons sem="G#cell_line">class II major histocompatibility complex mutant cell line clone- 13</cons> to the <cons sem="G#DNA_domain_or_region">divergent X2-box</cons>. --- > > <sentence>Mapping of the <cons sem="G#protein_domain_or_region">interaction site</cons> of the <cons sem="G#protein_family_or_group">defective <cons sem="G#protein_family_or_group">transcription factor</cons></cons> in the <cons sem="G#cell_line">class II major histocompatibility complex mutant cell line clone- 13</cons> to the <cons sem="G#DNA_domain_or_region">divergent X2-box</cons>.</sentence> > 1235c1373,1375 < Restoration of the <cons sem="G#protein_molecule"><cons sem="G#virus">Epstein-Barr virus</cons> ZEBRA protein</cons>'s capacity to disrupt latency by the addition of <cons sem="G#protein_domain_or_region">heterologous activation regions</cons>. --- > > <sentence>Restoration of the <cons sem="G#protein_molecule"><cons sem="G#virus">Epstein-Barr virus</cons> ZEBRA protein</cons>'s capacity to disrupt latency by the addition of <cons sem="G#protein_domain_or_region">heterologous activation regions</cons>.</sentence> > 1253,1254c1393,1396 < <cons sem="G#protein_molecule">Interleukin 4</cons> activates a <cons sem="G#other_name">signal transducer</cons> and <cons sem="G#other_name">activator</cons> of <cons sem="G#protein_family_or_group">transcription (Stat) protein</cons> which interacts with an <cons sem="G#DNA_domain_or_region">interferon-gamma activation site-like sequence</cons> upstream of the <cons sem="G#DNA_domain_or_region">I epsilon exon</cons> in a <cons sem="G#cell_line">human B cell line</cons>. < Evidence for the involvement of <cons sem="G#protein_molecule">Janus kinase 3</cons> and <cons sem="G#protein_molecule">interleukin-4 Stat</cons>. --- > > <sentence><cons sem="G#protein_molecule">Interleukin 4</cons> activates a <cons sem="G#other_name">signal transducer</cons> and <cons sem="G#other_name">activator</cons> of <cons sem="G#protein_family_or_group">transcription (Stat) protein</cons> which interacts with an <cons sem="G#DNA_domain_or_region">interferon-gamma activation site-like sequence</cons> upstream of the <cons sem="G#DNA_domain_or_region">I epsilon exon</cons> in a <cons sem="G#cell_line">human B cell line</cons>.</sentence> > <sentence>Evidence for the involvement of <cons sem="G#protein_molecule">Janus kinase 3</cons> and <cons sem="G#protein_molecule">interleukin-4 Stat</cons>.</sentence> > 1270c1412,1414 < Does activation of the <cons sem="G#DNA_domain_or_region">TAL1 gene</cons> occur in a majority of <cons sem="G#multi_cell">patients</cons> with <cons sem="G#other_name">T- cell acute lymphoblastic leukemia</cons>? A <cons sem="G#other_name">pediatric oncology group study</cons>. --- > > <sentence>Does activation of the <cons sem="G#DNA_domain_or_region">TAL1 gene</cons> occur in a majority of <cons sem="G#multi_cell">patients</cons> with <cons sem="G#other_name">T- cell acute lymphoblastic leukemia</cons>? A <cons sem="G#other_name">pediatric oncology group study</cons>.</sentence> > 1273c1417 < Although TAL1 expression has not been observed in normal lymphocytes, TAL1 gene products are readily detected in leukemic cells that harbor a rearranged TAL1 allele. --- > Although TAL1 expression has not been observed in normal lymphocytes, TAL1 gene products are readily detected in leukemic cells that harbor a rearranged TAL1 allele. 1287c1431,1433 < Expression of <cons sem="G#DNA_family_or_group">erythroid-specific genes</cons> in <cons sem="G#other_name">acute megakaryoblastic leukaemia</cons> and <cons sem="G#other_name">transient myeloproliferative disorder</cons> in <cons sem="G#other_name">Down's syndrome</cons>. --- > > <sentence>Expression of <cons sem="G#DNA_family_or_group">erythroid-specific genes</cons> in <cons sem="G#other_name">acute megakaryoblastic leukaemia</cons> and <cons sem="G#other_name">transient myeloproliferative disorder</cons> in <cons sem="G#other_name">Down's syndrome</cons>.</sentence> > 1301c1447,1449 < Expression of <cons sem="G#protein_molecule">Ah receptor</cons> (<cons sem="G#protein_molecule">TCDD receptor</cons>) during <cons sem="G#other_name">human monocytic differentiation</cons>. --- > > <sentence>Expression of <cons sem="G#protein_molecule">Ah receptor</cons> (<cons sem="G#protein_molecule">TCDD receptor</cons>) during <cons sem="G#other_name">human monocytic differentiation</cons>.</sentence> > 1322c1470,1472 < <cons sem="G#cell_type">Neutrophils</cons> and <cons sem="G#cell_type">monocytes</cons> express high levels of <cons sem="G#protein_molecule">PU.1</cons> (<cons sem="G#protein_molecule">Spi-1</cons>) but not <cons sem="G#protein_molecule">Spi-B</cons>. --- > > <sentence><cons sem="G#cell_type">Neutrophils</cons> and <cons sem="G#cell_type">monocytes</cons> express high levels of <cons sem="G#protein_molecule">PU.1</cons> (<cons sem="G#protein_molecule">Spi-1</cons>) but not <cons sem="G#protein_molecule">Spi-B</cons>.</sentence> > 1340c1490,1492 < Identification of a major <cons sem="G#DNA_family_or_group">positive regulatory element</cons> located 5' to the <cons sem="G#DNA_domain_or_region">human zeta-globin gene</cons>. --- > > <sentence>Identification of a major <cons sem="G#DNA_family_or_group">positive regulatory element</cons> located 5' to the <cons sem="G#DNA_domain_or_region">human zeta-globin gene</cons>.</sentence> > 1360c1512,1514 < Analysis of the role of <cons sem="(AND G#protein_molecule G#protein_molecule G#protein_molecule)"><cons>protein kinase C</cons><cons>-alpha</cons>, <cons>-epsilon</cons>, and <cons>-zeta</cons></cons> in <cons sem="G#other_name">T cell activation</cons>. --- > > <sentence>Analysis of the role of <cons sem="(AND G#protein_molecule G#protein_molecule G#protein_molecule)"><cons>protein kinase C</cons><cons>-alpha</cons>, <cons>-epsilon</cons>, and <cons>-zeta</cons></cons> in <cons sem="G#other_name">T cell activation</cons>.</sentence> > 1362c1516 < T cells express multiple isotypes of protein kinase C (PKC) and although it is well accepted that PKCs have an important role in T cell activation, little is known about the function of individual PKC isotypes. --- > T cells express multiple isotypes of protein kinase C (PKC) and although it is well accepted that PKCs have an important role in T cell activation, little is known about the function of individual PKC isotypes. 1380c1534,1536 < Differences in binding of <cons sem="G#protein_family_or_group">glucocorticoid receptor</cons> to DNA in <cons sem="G#other_name">steroid- resistant asthma</cons>. --- > > <sentence>Differences in binding of <cons sem="G#protein_family_or_group">glucocorticoid receptor</cons> to DNA in <cons sem="G#other_name">steroid- resistant asthma</cons>.</sentence> > 1387c1543 < Dexamethasone induced a significant rapid and sustained twofold increase in GRE binding in PBMCs from steroid-sensitive asthmatic patients and nonasthmatic individuals, but this was markedly reduced in steroid- resistant asthmatic patients. --- > Dexamethasone induced a significant rapid and sustained twofold increase in GRE binding in PBMCs from steroid-sensitive asthmatic patients and nonasthmatic individuals, but this was markedly reduced in steroid- resistant asthmatic patients. 1397c1553,1555 < <cons sem="G#other_name">Interleukin-5 signaling</cons> in <cons sem="G#cell_type">human eosinophils</cons> involves <cons sem="G#protein_molecule"><cons sem="G#protein_molecule">JAK2</cons> tyrosine kinase</cons> and <cons sem="G#protein_molecule">Stat1 alpha</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#protein_molecule">Interleukin-5</cons> signaling</cons> in <cons sem="G#cell_type">human eosinophils</cons> involves <cons sem="G#protein_molecule"><cons sem="G#protein_molecule">JAK2</cons> tyrosine kinase</cons> and <cons sem="G#protein_molecule">Stat1 alpha</cons>.</sentence> > 1415c1573,1575 < Infection and replication of <cons sem="G#virus">Tat- human immunodeficiency viruses</cons>: genetic analyses of <cons sem="G#DNA_domain_or_region">LTR</cons> and <cons sem="G#protein_family_or_group">tat mutations</cons> in <cons sem="(AND G#cell_type G#cell_type)"><cons>primary</cons> and <cons>long-term</cons> <cons>human lymphoid cells</cons></cons>. --- > > <sentence>Infection and replication of <cons sem="G#virus">Tat- human immunodeficiency viruses</cons>: genetic analyses of <cons sem="G#DNA_domain_or_region">LTR</cons> and <cons sem="G#protein_family_or_group">tat mutations</cons> in <cons sem="(AND G#cell_type G#cell_type)"><cons>primary</cons> and <cons>long-term</cons> <cons>human lymphoid cells</cons></cons>.</sentence> > 1436c1596,1598 < Functional roles of the <cons sem="G#protein_molecule">transcription factor <cons sem="G#protein_molecule">Oct-2A</cons></cons> and the <cons sem="G#protein_family_or_group">high mobility group protein</cons> <cons sem="G#protein_molecule">I/Y</cons> in <cons sem="G#other_name">HLA-DRA gene expression</cons>. --- > > <sentence>Functional roles of the <cons sem="G#protein_molecule">transcription factor <cons sem="G#protein_molecule">Oct-2A</cons></cons> and the <cons sem="G#protein_family_or_group">high mobility group protein</cons> <cons sem="G#protein_molecule">I/Y</cons> in <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">HLA-DRA gene</cons> expression</cons>.</sentence> > 1441,1444c1603,1606 < Coexpression of HMG I/Y and Oct-2 in cell lines lacking Oct-2 results in high levels of HLA-DRA gene expression, and in vitro DNA-binding studies reveal that HMG I/Y stimulates Oct-2A binding to the HLA-DRA promoter. < Thus, Oct-2A and HMG I/Y may synergize to activate HLA-DRA expression in B cells. < By contrast, Oct-2A is not involved in the IFN-gamma induction of the HLA- DRA gene in HeLa cells, but antisense HMG I/Y dramatically decreases the level of induction. < We conclude that distinct sets of transcription factors are involved in the two modes of HLA-DRA expression, and that HMG I/Y may be important for B cell-specific expression, and is essential for IFN-gamma induction. --- > Coexpression of HMG I/Y and Oct-2 in cell lines lacking Oct-2 results in high levels of HLA-DRA gene expression, and in vitro DNA-binding studies reveal that HMG I/Y stimulates Oct-2A binding to the HLA-DRA promoter. > Thus, Oct-2A and HMG I/Y may synergize to activate HLA-DRA expression in B cells. > By contrast, Oct-2A is not involved in the IFN-gamma induction of the HLA- DRA gene in HeLa cells, but antisense HMG I/Y dramatically decreases the level of induction. > We conclude that distinct sets of transcription factors are involved in the two modes of HLA-DRA expression, and that HMG I/Y may be important for B cell-specific expression, and is essential for IFN-gamma induction. 1452c1614,1616 < <cons sem="G#other_name">Heterogeneous expression</cons> of <cons sem="G#protein_family_or_group"><cons sem="G#virus">Epstein-Barr virus</cons> latent proteins</cons> in endemic <cons sem="G#other_name">Burkitt's lymphoma</cons>. --- > > <sentence><cons sem="G#other_name">Heterogeneous expression</cons> of <cons sem="G#protein_family_or_group"><cons sem="G#virus">Epstein-Barr virus</cons> latent proteins</cons> in endemic <cons sem="G#other_name">Burkitt's lymphoma</cons>.</sentence> > 1470c1634,1636 < The activation of the <cons sem="G#other_name">Jak-STAT 1 signaling pathway</cons> by <cons sem="G#protein_molecule">IL-5</cons> in <cons sem="G#cell_type">eosinophils</cons>. --- > > <sentence>The activation of the <cons sem="G#other_name"><cons sem="G#protein_family_or_group">Jak</cons>-<cons sem="G#protein_molecule">STAT 1</cons> signaling pathway</cons> by <cons sem="G#protein_molecule">IL-5</cons> in <cons sem="G#cell_type">eosinophils</cons>.</sentence> > 1473c1639 < The objective of this study was to investigate the involvement of the newly discovered Jak-STAT pathway in the IL-5 signal transduction mechanism. --- > The objective of this study was to investigate the involvement of the newly discovered Jak-STAT pathway in the IL-5 signal transduction mechanism. 1485,1486c1651,1652 < Thus, we demonstrated that IL-5 activated the Jak 2-STAT 1 signaling pathway in eosinophils. < We speculate that the Jak 2-STAT 1 pathway may be involved in the activation of IL-5-inducible genes in eosinophils. --- > Thus, we demonstrated that IL-5 activated the Jak 2-STAT 1 signaling pathway in eosinophils. > We speculate that the Jak 2-STAT 1 pathway may be involved in the activation of IL-5-inducible genes in eosinophils. 1494c1660,1662 < Reduced <cons sem="G#other_name">mitogenic stimulation</cons> of <cons sem="G#cell_type">peripheral blood mononuclear cells</cons> as a prognostic parameter for the course of <cons sem="G#other_name">breast cancer</cons>: a <cons sem="G#other_name">prospective longitudinal study</cons>. --- > > <sentence>Reduced <cons sem="G#other_name">mitogenic stimulation</cons> of <cons sem="G#cell_type">peripheral blood mononuclear cells</cons> as a prognostic parameter for the course of <cons sem="G#other_name">breast cancer</cons>: a <cons sem="G#other_name">prospective longitudinal study</cons>.</sentence> > 1511c1679,1681 < <cons sem="G#other_name">Activation of transcription</cons> by binding of <cons sem="G#protein_molecule">NF-E1</cons> (<cons sem="G#protein_molecule">YY1</cons>) to a newly identified element in the first exon of the <cons sem="G#DNA_domain_or_region">human DR alpha gene</cons>. --- > > <sentence><cons sem="G#other_name">Activation of transcription</cons> by binding of <cons sem="G#protein_molecule">NF-E1</cons> (<cons sem="G#protein_molecule">YY1</cons>) to a newly identified element in the first exon of the <cons sem="G#DNA_domain_or_region">human DR alpha gene</cons>.</sentence> > 1514,1515c1684,1685 < Mutations in this DNA-binding site abolished binding of a nuclear factor in human B cell nuclear extract and decreased the activity of the DR alpha promoter to a basal level. < Significant sequence homology of this element was found in the DNA of the DR beta, DP alpha and -beta, and DQ alpha genes, always located downstream of the transcriptional start site. --- > Mutations in this DNA-binding site abolished binding of a nuclear factor in human B cell nuclear extract and decreased the activity of the DR alpha promoter to a basal level. > Significant sequence homology of this element was found in the DNA of the DR beta, DP alpha and -beta, and DQ alpha genes, always located downstream of the transcriptional start site. 1526c1696,1698 < <cons sem="G#other_name">Transcriptional activity</cons> of <cons sem="(AND G#protein_subunit G#protein_subunit)"><cons>core binding factor-</cons><cons>alpha (AML1)</cons> and <cons>beta</cons></cons> subunits on <cons sem="G#DNA_domain_or_region"><cons sem="G#virus">murine leukemia virus</cons> enhancer cores</cons>. --- > > <sentence><cons sem="G#other_name">Transcriptional activity</cons> of <cons sem="(AND G#protein_subunit G#protein_subunit)"><cons>core binding factor-</cons><cons>alpha (AML1)</cons> and <cons>beta</cons></cons> subunits on <cons sem="G#DNA_domain_or_region"><cons sem="G#virus">murine leukemia virus</cons> enhancer cores</cons>.</sentence> > 1551,1552c1723,1726 < <cons sem="G#protein_molecule">Interleukin (IL)-10</cons> inhibits <cons sem="G#other_name"><cons sem="G#protein_molecule">nuclear factor kappa B</cons> (<cons sem="G#protein_molecule">NF kappa B</cons>) activation</cons> in <cons sem="G#cell_type">human monocytes</cons>. < <cons sem="G#protein_molecule">IL-10</cons> and <cons sem="G#protein_molecule">IL-4</cons> suppress <cons sem="G#other_name">cytokine synthesis</cons> by different mechanisms. --- > > <sentence><cons sem="G#protein_molecule">Interleukin (IL)-10</cons> inhibits <cons sem="G#other_name"><cons sem="G#protein_molecule">nuclear factor kappa B</cons> (<cons sem="G#protein_molecule">NF kappa B</cons>) activation</cons> in <cons sem="G#cell_type">human monocytes</cons>. > <cons sem="G#protein_molecule">IL-10</cons> and <cons sem="G#protein_molecule">IL-4</cons> suppress <cons sem="G#other_name"><cons sem="G#protein_family_or_group">cytokine</cons> synthesis</cons> by different mechanisms.</sentence> > 1556c1730 < This selective inhibition by IL-10 of NF kappa B activation occurs rapidly and in a dose-dependent manner and correlates well with IL-10's cytokine synthesis inhibitory activity in terms of both kinetics and dose responsiveness. --- > This selective inhibition by IL-10 of NF kappa B activation occurs rapidly and in a dose-dependent manner and correlates well with IL-10's cytokine synthesis inhibitory activity in terms of both kinetics and dose responsiveness. 1561c1735 < These data indicate that IL-10 and IL-4 inhibit cytokine production by different mechanisms. --- > These data indicate that IL-10 and IL-4 inhibit cytokine production by different mechanisms. 1569c1743,1745 < <cons sem="G#protein_molecule">LMP-1</cons> activates <cons sem="G#protein_molecule">NF-kappa B</cons> by targeting the <cons sem="G#protein_molecule">inhibitory molecule <cons sem="G#protein_molecule">I kappa B alpha</cons></cons>. --- > > <sentence><cons sem="G#protein_molecule">LMP-1</cons> activates <cons sem="G#protein_molecule">NF-kappa B</cons> by targeting the <cons sem="G#protein_molecule">inhibitory molecule <cons sem="G#protein_molecule">I kappa B alpha</cons></cons>.</sentence> > 1589c1765,1767 < Identification of <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">human TR2 orphan receptor</cons> response element</cons> in the <cons sem="G#DNA_domain_or_region">transcriptional initiation site</cons> of the <cons sem="G#DNA_domain_or_region"><cons sem="G#virus">simian virus 40</cons> major late promoter</cons> [published erratum appears in J Biol Chem 1995 Nov 3;270(44):26721] --- > > <sentence>Identification of <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">human TR2 orphan receptor</cons> response element</cons> in the <cons sem="G#DNA_domain_or_region">transcriptional initiation site</cons> of the <cons sem="G#DNA_domain_or_region"><cons sem="G#virus">simian virus 40</cons> major late promoter</cons> [published erratum appears in J Biol Chem 1995 Nov 3;270(44):26721]</sentence> > 1603c1781,1783 < Detection of the <cons sem="G#RNA_molecule"><cons sem="G#DNA_molecule">chromosome 16</cons> CBF beta-MYH11 fusion transcript</cons> in <cons sem="G#other_name">myelomonocytic leukemias</cons>. --- > > <sentence>Detection of the <cons sem="G#RNA_molecule"><cons sem="G#DNA_molecule">chromosome 16</cons> CBF beta-MYH11 fusion transcript</cons> in <cons sem="G#other_name">myelomonocytic leukemias</cons>.</sentence> > 1615c1795 < These data show that CBF beta-MYH11 fusion transcripts occur not only in the vast majority of typical AML M4Eo, but also in approximately 10% of AML M4 without eosinophilic abnormalities, a much higher incidence than the sporadic reports of chromosome 16 abnormalities in AML M4 would suggest. --- > These data show that CBF beta-MYH11 fusion transcripts occur not only in the vast majority of typical AML M4Eo, but also in approximately 10% of AML M4 without eosinophilic abnormalities, a much higher incidence than the sporadic reports of chromosome 16 abnormalities in AML M4 would suggest. 1624c1804,1806 < <cons sem="G#protein_molecule"><cons sem="G#virus">HIV-1</cons> Tat</cons> potentiates <cons sem="G#other_name">TNF-induced NF-kappa B activation</cons> and <cons sem="G#other_name">cytotoxicity</cons> by altering the cellular redox state. --- > > <sentence><cons sem="G#protein_molecule"><cons sem="G#virus">HIV-1</cons> Tat</cons> potentiates <cons sem="G#other_name"><cons sem="G#protein_family_or_group">TNF</cons>-induced <cons sem="G#protein_molecule">NF-kappa B</cons> activation</cons> and <cons sem="G#other_name">cytotoxicity</cons> by altering the cellular redox state.</sentence> > 1630c1812 < Therefore, Tat-mediated effects on the cellular redox state were analyzed. --- > Therefore, Tat-mediated effects on the cellular redox state were analyzed. 1634,1635c1816,1817 < A truncated Tat protein (Tat1-72), known to transactivate the HIV-1 long terminal repeat (LTR), no longer affected Mn-SOD expression, the cellular redox state or TNF- mediated cytotoxicity. < Thus, our experiments demonstrate that the C- terminal region of HIV-1 Tat is required to suppress Mn-SOD expression and to induce pro-oxidative conditions reflected by a drop in reduced glutathione (GSH) and the GSH:oxidized GSH (GSSG) ratio. --- > A truncated Tat protein (Tat1-72), known to transactivate the HIV-1 long terminal repeat (LTR), no longer affected Mn-SOD expression, the cellular redox state or TNF- mediated cytotoxicity. > Thus, our experiments demonstrate that the C- terminal region of HIV-1 Tat is required to suppress Mn-SOD expression and to induce pro-oxidative conditions reflected by a drop in reduced glutathione (GSH) and the GSH:oxidized GSH (GSSG) ratio. 1644,1645c1826,1829 < The use of <cons sem="G#lipid">glucocorticoids</cons> in <cons sem="G#other_name">acute lymphoblastic leukemia</cons> of childhood. < Molecular, cellular, and clinical considerations. --- > > <sentence>The use of <cons sem="G#lipid">glucocorticoids</cons> in <cons sem="G#other_name">acute lymphoblastic leukemia</cons> of childhood.</sentence> > <sentence>Molecular, cellular, and clinical considerations.</sentence> > 1661c1845,1847 < <cons sem="G#other_name"><cons sem="G#protein_molecule"><cons sem="G#virus">Epstein-Barr virus</cons> nuclear protein 2</cons> transactivation</cons> of the <cons sem="G#DNA_domain_or_region">latent membrane protein 1 promoter</cons> is mediated by <cons sem="G#protein_molecule">J kappa</cons> and <cons sem="G#protein_molecule">PU.1</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#protein_molecule"><cons sem="G#virus">Epstein-Barr virus</cons> nuclear protein 2</cons> transactivation</cons> of the <cons sem="G#DNA_domain_or_region">latent membrane protein 1 promoter</cons> is mediated by <cons sem="G#protein_molecule">J kappa</cons> and <cons sem="G#protein_molecule">PU.1</cons>.</sentence> > 1683c1869,1871 < <cons sem="G#protein_family_or_group">Lymphocyte <cons sem="G#lipid">glucocorticoid</cons> receptor</cons>: predictor of <cons sem="G#other_name"><cons sem="G#other_organic_compound">sertraline</cons> response</cons> in <cons sem="G#other_name">adolescent major depressive disorder</cons> (<cons sem="G#other_name">MDD</cons>). --- > > <sentence><cons sem="G#protein_family_or_group">Lymphocyte <cons sem="G#lipid">glucocorticoid</cons> receptor</cons>: predictor of <cons sem="G#other_name"><cons sem="G#other_organic_compound">sertraline</cons> response</cons> in <cons sem="G#other_name">adolescent major depressive disorder</cons> (<cons sem="G#other_name">MDD</cons>).</sentence> > 1700c1888,1890 < The role of <cons sem="G#protein_molecule">NFATp</cons> in <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">cyclosporin A-sensitive tumor necrosis factor</cons>- alpha gene</cons> transcription</cons>. --- > > <sentence>The role of <cons sem="G#protein_molecule">NFATp</cons> in <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">cyclosporin A-sensitive tumor necrosis factor</cons>- alpha gene</cons> transcription</cons>.</sentence> > 1703c1893 < Maximal induction of TNF alpha mRNA can be induced by treatment of T cells with calcium ionophores alone, via a calcineurin-dependent process that is blocked by cyclosporin A. --- > Maximal induction of TNF alpha mRNA can be induced by treatment of T cells with calcium ionophores alone, via a calcineurin-dependent process that is blocked by cyclosporin A. 1716c1906,1908 < Regulation and specificity of <cons sem="G#other_name"><cons sem="G#protein_molecule">MNDA</cons> expression</cons> in <cons sem="G#cell_type">monocytes</cons>, <cons sem="G#cell_type">macrophages</cons>, and <cons sem="G#cell_line">leukemia/B lymphoma cell lines</cons>. --- > > <sentence>Regulation and specificity of <cons sem="G#other_name"><cons sem="G#protein_molecule">MNDA</cons> expression</cons> in <cons sem="G#cell_type">monocytes</cons>, <cons sem="G#cell_type">macrophages</cons>, and <cons sem="G#cell_line">leukemia/B lymphoma cell lines</cons>.</sentence> > 1724c1916 < Three additional agents (endotoxin, phytohemagglutinin, and phorbol ester) and other conditions that affect function, cytokine production, differentiation, and/or growth of monocytes were examined for their ability to alter MNDA expression. --- > Three additional agents (endotoxin, phytohemagglutinin, and phorbol ester) and other conditions that affect function, cytokine production, differentiation, and/or growth of monocytes were examined for their ability to alter MNDA expression. 1736c1928,1930 < DNA-binding studies of the <cons sem="G#protein_molecule"><cons sem="G#virus">Epstein-Barr virus</cons> nuclear antigen 2</cons> (<cons sem="G#protein_molecule">EBNA- 2</cons>): evidence for complex formation by <cons sem="G#protein_family_or_group">latent membrane protein gene promoter-binding proteins</cons> in <cons sem="G#cell_line"><cons sem="G#protein_molecule">EBNA-2</cons>-positive cell lines</cons>. --- > > <sentence>DNA-binding studies of the <cons sem="G#protein_molecule"><cons sem="G#virus">Epstein-Barr virus</cons> nuclear antigen 2</cons> (<cons sem="G#protein_molecule">EBNA- 2</cons>): evidence for complex formation by <cons sem="G#protein_family_or_group">latent membrane protein gene promoter-binding proteins</cons> in <cons sem="G#cell_line"><cons sem="G#protein_molecule">EBNA-2</cons>-positive cell lines</cons>.</sentence> > 1746c1940 < No significant differences between EBNA-2-positive and EBNA-2-negative nuclear extracts could be seen in the gel retardation assay under conditions that clearly showed binding of EBNA-2A to the TP1 promoter. --- > No significant differences between EBNA-2-positive and EBNA-2-negative nuclear extracts could be seen in the gel retardation assay under conditions that clearly showed binding of EBNA-2A to the TP1 promoter. 1757c1951,1953 < Simultaneous activation of <cons sem="G#protein_family_or_group">Ig</cons> and <cons sem="G#other_name"><cons sem="G#protein_molecule">Oct-2</cons> synthesis</cons> and reduction of surface <cons sem="G#other_name">MHC class II expression</cons> by <cons sem="G#protein_molecule">IL-6</cons>. --- > > <sentence>Simultaneous activation of <cons sem="G#protein_family_or_group">Ig</cons> and <cons sem="G#other_name"><cons sem="G#protein_molecule">Oct-2</cons> synthesis</cons> and reduction of surface <cons sem="G#other_name"><cons sem="G#protein_family_or_group">MHC class II</cons> expression</cons> by <cons sem="G#protein_molecule">IL-6</cons>.</sentence> > 1759c1955 < Terminal differentiation of B cells to plasma cells in vivo is characterized by secretion of Ig and extinction of MHC class II expression on the cell surface. --- > Terminal differentiation of B cells to plasma cells in vivo is characterized by secretion of Ig and extinction of MHC class II expression on the cell surface. 1773c1969,1971 < <cons sem="G#DNA_domain_or_region">T-cell functional regions</cons> of the <cons sem="G#DNA_domain_or_region">human IL-3 proximal promoter</cons>. --- > > <sentence><cons sem="G#DNA_domain_or_region">T-cell functional regions</cons> of the <cons sem="G#DNA_domain_or_region">human IL-3 proximal promoter</cons>.</sentence> > 1790c1988,1990 < Expression of the <cons sem="G#DNA_family_or_group"><cons sem="G#protein_domain_or_region">Runt domain</cons>-encoding PEBP2 alpha genes</cons> in <cons sem="G#cell_type">T cells</cons> during <cons sem="G#other_name">thymic development</cons>. --- > > <sentence>Expression of the <cons sem="G#DNA_family_or_group"><cons sem="G#protein_domain_or_region">Runt domain</cons>-encoding PEBP2 alpha genes</cons> in <cons sem="G#cell_type">T cells</cons> during <cons sem="G#other_name">thymic development</cons>.</sentence> > 1796c1996 < Furthermore, transcripts of PEBP2 alpha A and mouse AML1/PEBP2 alpha B were detected in T lymphocytes in the thymuses from day 16 embryos and newborns, as well as 4-week-old adult mice, by in situ hybridization. --- > Furthermore, transcripts of PEBP2 alpha A and mouse AML1/PEBP2 alpha B were detected in T lymphocytes in the thymuses from day 16 embryos and newborns, as well as 4-week-old adult mice, by in situ hybridization. 1809c2009,2011 < Effects of <cons sem="G#lipid">glucocorticoids</cons> on <cons sem="G#other_name">transcription factor activation</cons> in <cons sem="G#cell_type">human peripheral blood mononuclear cells</cons>. --- > > <sentence>Effects of <cons sem="G#lipid">glucocorticoids</cons> on <cons sem="G#other_name">transcription factor activation</cons> in <cons sem="G#cell_type">human peripheral blood mononuclear cells</cons>.</sentence> > 1814c2016 < Dexamethasone produced a rapid and sustained increase in glucocorticoid response element binding and a concomitant 40-50% decrease in AP-1, NF kappa B, and CREB DNA binding that was blocked by combined dexamethasone and cytokine or PMA treatment. --- > Dexamethasone produced a rapid and sustained increase in glucocorticoid response element binding and a concomitant 40-50% decrease in AP-1, NF kappa B, and CREB DNA binding that was blocked by combined dexamethasone and cytokine or PMA treatment. 1825c2027,2029 < <cons sem="G#other_name">Differential induction</cons> of the <cons sem="G#protein_complex">NF-AT complex</cons> during <cons sem="G#other_name">restimulation</cons> and the induction of <cons sem="G#other_name">T-cell anergy</cons>. --- > > <sentence><cons sem="G#other_name">Differential induction</cons> of the <cons sem="G#protein_complex">NF-AT complex</cons> during <cons sem="G#other_name">restimulation</cons> and the induction of <cons sem="G#other_name">T-cell anergy</cons>.</sentence> > 1828c2032 < During the induction of anergy, T cells are phenotypically similar to cells responding to an immunogenic stimulus. --- > During the induction of anergy, T cells are phenotypically similar to cells responding to an immunogenic stimulus. 1845c2049,2051 < The number of <cons sem="G#protein_family_or_group">glucocorticoid receptors</cons> in <cons sem="G#cell_type">peripheral human lymphocytes</cons> is elevated by a <cons sem="G#other_name"><cons sem="G#atom">zinc</cons> containing trace element preparation</cons>. --- > > <sentence>The number of <cons sem="G#protein_family_or_group">glucocorticoid receptors</cons> in <cons sem="G#cell_type">peripheral human lymphocytes</cons> is elevated by a <cons sem="G#other_name"><cons sem="G#atom">zinc</cons> containing trace element preparation</cons>.</sentence> > 1858c2064,2066 < The DNA and <cons sem="G#protein_domain_or_region"><cons sem="G#lipid">steroid</cons> binding domains</cons> of the <cons sem="G#protein_family_or_group">glucocorticoid receptor</cons> are not altered in <cons sem="G#cell_type">mononuclear cells</cons> of <cons sem="G#multi_cell">treated CLL <cons sem="G#multi_cell">patients</cons></cons>. --- > > <sentence>The DNA and <cons sem="G#protein_domain_or_region"><cons sem="G#lipid">steroid</cons> binding domains</cons> of the <cons sem="G#protein_family_or_group">glucocorticoid receptor</cons> are not altered in <cons sem="G#cell_type">mononuclear cells</cons> of <cons sem="G#multi_cell">treated CLL <cons sem="G#multi_cell">patients</cons></cons>.</sentence> > 1874c2082,2084 < An <cons sem="G#DNA_domain_or_region">AP1 binding site</cons> upstream of the <cons sem="G#DNA_domain_or_region">kappa immunoglobulin intron enhancer</cons> binds <cons sem="G#protein_family_or_group">inducible factors</cons> and contributes to expression. --- > > <sentence>An <cons sem="G#DNA_domain_or_region">AP1 binding site</cons> upstream of the <cons sem="G#DNA_domain_or_region">kappa immunoglobulin intron enhancer</cons> binds <cons sem="G#protein_family_or_group">inducible factors</cons> and contributes to expression.</sentence> > 1889c2099,2101 < Distinct <cons sem="G#DNA_domain_or_region">DNase-I hypersensitive sites</cons> are associated with <cons sem="G#other_name"><cons sem="G#protein_molecule">TAL-1</cons> transcription</cons> in <cons sem="(AND G#cell_line G#cell_line)"><cons>erythroid</cons> and <cons>T-cell</cons> <cons>lines</cons></cons>. --- > > <sentence>Distinct <cons sem="G#DNA_domain_or_region">DNase-I hypersensitive sites</cons> are associated with <cons sem="G#other_name"><cons sem="G#protein_molecule">TAL-1</cons> transcription</cons> in <cons sem="(AND G#cell_line G#cell_line)"><cons>erythroid</cons> and <cons>T-cell</cons> <cons>lines</cons></cons>.</sentence> > 1907c2119,2121 < <cons sem="G#other_name">Erythropoietin-dependent induction</cons> of <cons sem="G#other_name">hemoglobin synthesis</cons> in a <cons sem="G#cell_line"><cons sem="G#protein_family_or_group">cytokine</cons>-dependent cell line</cons> <cons sem="G#cell_line">M-TAT</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#protein_molecule">Erythropoietin</cons>-dependent induction</cons> of <cons sem="G#other_name"><cons sem="G#protein_complex">hemoglobin</cons> synthesis</cons> in a <cons sem="G#cell_line"><cons sem="G#protein_family_or_group">cytokine</cons>-dependent cell line</cons> <cons sem="G#cell_line">M-TAT</cons>.</sentence> > 1913c2127 < When the supplemented cytokine was switched from GM-CSF to EPO, hemoglobin synthesis in M- TAT/GM-CSF cells increased rapidly (within 5 h), and the level of GATA- 1 mRNA increased. --- > When the supplemented cytokine was switched from GM-CSF to EPO, hemoglobin synthesis in M- TAT/GM-CSF cells increased rapidly (within 5 h), and the level of GATA- 1 mRNA increased. 1924c2138,2140 < The role of <cons sem="G#protein_molecule">cellular <cons sem="G#protein_family_or_group">transcription factor</cons> E2F</cons> in the regulation of <cons sem="G#other_name"><cons sem="G#RNA_molecule">cdc2 mRNA</cons> expression</cons> and <cons sem="G#other_name">cell cycle control</cons> of human <cons sem="G#cell_type">hematopoietic cells</cons>. --- > > <sentence>The role of <cons sem="G#protein_molecule">cellular <cons sem="G#protein_family_or_group">transcription factor</cons> E2F</cons> in the regulation of <cons sem="G#other_name"><cons sem="G#RNA_molecule">cdc2 mRNA</cons> expression</cons> and <cons sem="G#other_name">cell cycle control</cons> of human <cons sem="G#cell_type">hematopoietic cells</cons>.</sentence> > 1943c2159,2161 < Association of alterations in <cons sem="G#protein_family_or_group">NF-kappa B moieties</cons> with <cons sem="G#other_name"><cons sem="G#virus">HIV type 1</cons> proviral latency</cons> in certain <cons sem="G#cell_type">monocytic cells</cons>. --- > > <sentence>Association of alterations in <cons sem="G#protein_family_or_group">NF-kappa B moieties</cons> with <cons sem="G#other_name"><cons sem="G#virus">HIV type 1</cons> proviral latency</cons> in certain <cons sem="G#cell_type">monocytic cells</cons>.</sentence> > 1959c2177,2179 < [Regulation of <cons sem="G#other_name">transcription</cons> of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">interleukin-2</cons> gene</cons> in <cons sem="G#cell_type">B-lymphocytes</cons>] --- > > <sentence>[Regulation of <cons sem="G#other_name">transcription</cons> of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">interleukin-2</cons> gene</cons> in <cons sem="G#cell_type">B-lymphocytes</cons>]</sentence> > 1973c2193,2195 < Regulation of <cons sem="G#protein_molecule">I kappa B alpha</cons> and <cons sem="G#protein_molecule">p105</cons> in <cons sem="G#cell_type">monocytes</cons> and <cons sem="G#cell_type">macrophages</cons> persistently infected with <cons sem="G#virus">human immunodeficiency virus</cons>. --- > > <sentence>Regulation of <cons sem="G#protein_molecule">I kappa B alpha</cons> and <cons sem="G#protein_molecule">p105</cons> in <cons sem="G#cell_type">monocytes</cons> and <cons sem="G#cell_type">macrophages</cons> persistently infected with <cons sem="G#virus">human immunodeficiency virus</cons>.</sentence> > 1993c2215,2217 < <cons sem="G#other_name"><cons sem="G#lipid">Glucocorticoid</cons>-induced apoptosis</cons> of <cons sem="G#cell_type">human leukemic cells</cons> is caused by the repressive function of the <cons sem="G#protein_family_or_group">glucocorticoid receptor</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#lipid">Glucocorticoid</cons>-induced apoptosis</cons> of <cons sem="G#cell_type">human leukemic cells</cons> is caused by the repressive function of the <cons sem="G#protein_family_or_group">glucocorticoid receptor</cons>.</sentence> > 2008c2232,2234 < <cons sem="G#other_name"><cons sem="G#virus">HIV type 1</cons> protease activation</cons> of <cons sem="G#protein_molecule">NF-kappa B</cons> within <cons sem="G#cell_type">T lymphoid cells</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#virus">HIV type 1</cons> <cons sem="G#protein_family_or_group">protease</cons> activation</cons> of <cons sem="G#protein_molecule">NF-kappa B</cons> within <cons sem="G#cell_type">T lymphoid cells</cons>.</sentence> > 2014c2240 < Viral transcription, as measured using LTR-CAT assays, was only slightly enhanced in the HIV-protease expressing cells, while secretion of IL-2 and expression of the IL-2 receptor were not affected. --- > Viral transcription, as measured using LTR-CAT assays, was only slightly enhanced in the HIV-protease expressing cells, while secretion of IL-2 and expression of the IL-2 receptor were not affected. 2023c2249,2251 < Inhibition of <cons sem="G#virus">human immunodeficiency virus type 1</cons> replication by a <cons sem="G#DNA_domain_or_region">Tat- activated, transduced interferon gene</cons>: targeted expression to <cons sem="G#cell_type"><cons sem="G#virus">human immunodeficiency virus type 1</cons>-infected cells</cons>. --- > > <sentence>Inhibition of <cons sem="G#virus">human immunodeficiency virus type 1</cons> replication by a <cons sem="G#DNA_domain_or_region">Tat- activated, transduced interferon gene</cons>: targeted expression to <cons sem="G#cell_type"><cons sem="G#virus">human immunodeficiency virus type 1</cons>-infected cells</cons>.</sentence> > 2025c2253 < We have examined the feasibility of using interferon (IFN) gene transfer as a novel approach to anti-human immunodeficiency virus type 1 (HIV-1) therapy in this study. --- > We have examined the feasibility of using interferon (IFN) gene transfer as a novel approach to anti-human immunodeficiency virus type 1 (HIV-1) therapy in this study. 2027,2029c2255,2257 < Deletion of the NF-kappa B elements of the HIV-1 LTR significantly inhibited Tat-mediated transactivation in T-cell lines, as well as in a monocyte line, U937. < Replacement of the NF-kappa B elements in the HIV-1 LTR by a DNA fragment derived from the 5'-flanking region of IFN-stimulated gene 15 (ISG15), containing the IFN-stimulated response element, partially restored Tat-mediated activation of LTR in T cells as well as in monocytes. < Insertion of this chimeric promoter (ISG15 LTR) upstream of the human IFNA2 gene directed high levels of IFN synthesis in Tat- expressing cells, while this promoter was not responsive to tumor necrosis factor alpha-mediated activation. --- > Deletion of the NF-kappa B elements of the HIV-1 LTR significantly inhibited Tat-mediated transactivation in T-cell lines, as well as in a monocyte line, U937. > Replacement of the NF-kappa B elements in the HIV-1 LTR by a DNA fragment derived from the 5'-flanking region of IFN-stimulated gene 15 (ISG15), containing the IFN-stimulated response element, partially restored Tat-mediated activation of LTR in T cells as well as in monocytes. > Insertion of this chimeric promoter (ISG15 LTR) upstream of the human IFNA2 gene directed high levels of IFN synthesis in Tat- expressing cells, while this promoter was not responsive to tumor necrosis factor alpha-mediated activation. 2034c2262 < These results suggest that targeting IFN synthesis to HIV-1-infected cells is an attainable goal and that autocrine IFN synthesis results in a long-lasting and permanent suppression of HIV-1 replication. --- > These results suggest that targeting IFN synthesis to HIV-1-infected cells is an attainable goal and that autocrine IFN synthesis results in a long-lasting and permanent suppression of HIV-1 replication. 2042c2270,2272 < <cons sem="G#other_name">Chromosomal localization</cons> of two <cons sem="G#DNA_family_or_group">KOX zinc finger genes</cons> on <cons sem="G#DNA_domain_or_region">chromosome bands</cons> <cons sem="G#DNA_domain_or_region">7q21-q22</cons>. --- > > <sentence><cons sem="G#other_name">Chromosomal localization</cons> of two <cons sem="G#DNA_family_or_group">KOX zinc finger genes</cons> on <cons sem="G#DNA_domain_or_region">chromosome bands</cons> <cons sem="G#DNA_domain_or_region">7q21-q22</cons>.</sentence> > 2056c2286,2288 < Influence of age on the production of <cons sem="G#protein_molecule">Fos</cons> and <cons sem="G#protein_molecule">Jun</cons> by <cons sem="G#cell_type">influenza virus- exposed <cons sem="G#cell_type">T cells</cons></cons>. --- > > <sentence>Influence of age on the production of <cons sem="G#protein_molecule">Fos</cons> and <cons sem="G#protein_molecule">Jun</cons> by <cons sem="G#cell_type">influenza virus- exposed <cons sem="G#cell_type">T cells</cons></cons>.</sentence> > 2071c2303,2305 < The regulation of <cons sem="G#virus">HIV</cons> by <cons sem="G#other_organic_compound">retinoic acid</cons> correlates with cellular expression of the <cons sem="G#protein_family_or_group"><cons sem="G#other_organic_compound">retinoic acid</cons> receptors</cons>. --- > > <sentence>The regulation of <cons sem="G#virus">HIV</cons> by <cons sem="G#other_organic_compound">retinoic acid</cons> correlates with cellular expression of the <cons sem="G#protein_family_or_group"><cons sem="G#other_organic_compound">retinoic acid</cons> receptors</cons>.</sentence> > 2073c2307 < OBJECTIVES: To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines. --- > OBJECTIVES: To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines. 2084c2318 < CONCLUSION: The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs. --- > CONCLUSION: The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs. 2093c2327,2329 < Functions of <cons sem="G#peptide">glutathione</cons> and <cons sem="G#peptide">glutathione disulfide</cons> in <cons sem="G#other_name">immunology</cons> and <cons sem="G#other_name">immunopathology</cons>. --- > > <sentence>Functions of <cons sem="G#peptide">glutathione</cons> and <cons sem="G#peptide">glutathione disulfide</cons> in <cons sem="G#other_name">immunology</cons> and <cons sem="G#other_name">immunopathology</cons>.</sentence> > 2098c2334 < As the protein tyrosine kinase activities p56lck and p59fyn are activated in intact cells by hydrogen peroxide, they are likely targets for GSSG action. --- > As the protein tyrosine kinase activities p56lck and p59fyn are activated in intact cells by hydrogen peroxide, they are likely targets for GSSG action. 2110c2346,2348 < <cons sem="G#cell_type">T cells</cons> from <cons sem="G#multi_cell"><cons sem="G#other_name">renal cell carcinoma</cons> patients</cons> exhibit an abnormal pattern of <cons sem="G#other_name">kappa B-specific DNA-binding activity</cons>: a preliminary report. --- > > <sentence><cons sem="G#cell_type">T cells</cons> from <cons sem="G#multi_cell"><cons sem="G#other_name">renal cell carcinoma</cons> patients</cons> exhibit an abnormal pattern of <cons sem="G#other_name">kappa B-specific DNA-binding activity</cons>: a preliminary report.</sentence> > 2127c2365,2367 < <cons sem="G#other_name"><cons sem="G#protein_molecule">Hemoglobin</cons> switching</cons> in humans is accompanied by changes in the ratio of the <cons sem="G#protein_family_or_group">transcription factors</cons>, <cons sem="G#protein_molecule">GATA-1</cons> and <cons sem="G#protein_molecule">SP1</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#protein_molecule">Hemoglobin</cons> switching</cons> in humans is accompanied by changes in the ratio of the <cons sem="G#protein_family_or_group">transcription factors</cons>, <cons sem="G#protein_molecule">GATA-1</cons> and <cons sem="G#protein_molecule">SP1</cons>.</sentence> > 2129c2369 < BACKGROUND: Understanding the mechanism of developmental regulation of hemoglobin switching has scientific as well as clinical relevance because of the influence of fetal hemoglobin (HbF) production in adulthood on the clinical manifestation of thalassemia and sickle cell anemia. --- > BACKGROUND: Understanding the mechanism of developmental regulation of hemoglobin switching has scientific as well as clinical relevance because of the influence of fetal hemoglobin (HbF) production in adulthood on the clinical manifestation of thalassemia and sickle cell anemia. 2147c2387,2389 < <cons sem="G#other_name">Transcription-independent turnover</cons> of <cons sem="G#protein_molecule">I kappa B alpha</cons> during <cons sem="G#other_name">monocyte adherence</cons>: implications for a translational component regulating <cons sem="G#other_name"><cons sem="G#RNA_molecule"><cons sem="G#protein_molecule">I kappa B alpha</cons>/<cons sem="G#protein_molecule">MAD-3</cons> mRNA</cons> levels</cons>. --- > > <sentence><cons sem="G#other_name">Transcription-independent turnover</cons> of <cons sem="G#protein_molecule">I kappa B alpha</cons> during <cons sem="G#other_name">monocyte adherence</cons>: implications for a translational component regulating <cons sem="G#other_name"><cons sem="G#RNA_molecule"><cons sem="G#protein_molecule">I kappa B alpha</cons>/<cons sem="G#protein_molecule">MAD-3</cons> mRNA</cons> levels</cons>.</sentence> > 2166c2408,2410 < Distinct roles of the molecular <cons sem="G#protein_molecule">chaperone hsp90</cons> in modulating dioxin receptor function via the basic <cons sem="G#protein_substructure">helix-loop-helix</cons> and <cons sem="G#protein_domain_or_region">PAS domains</cons>. --- > > <sentence>Distinct roles of the molecular <cons sem="G#protein_molecule">chaperone hsp90</cons> in modulating dioxin receptor function via the basic <cons sem="G#protein_substructure">helix-loop-helix</cons> and <cons sem="G#protein_domain_or_region">PAS domains</cons>.</sentence> > 2187c2431,2433 < Induction of <cons sem="G#protein_family_or_group">transcription factors</cons> in <cons sem="G#cell_type">human T lymphocytes</cons> by <cons sem="G#other_organic_compound"><cons sem="G#other_organic_compound">aspirin</cons>- like drugs</cons>. --- > > <sentence>Induction of <cons sem="G#protein_family_or_group">transcription factors</cons> in <cons sem="G#cell_type">human T lymphocytes</cons> by <cons sem="G#other_organic_compound"><cons sem="G#other_organic_compound">aspirin</cons>- like drugs</cons>.</sentence> > 2206c2452,2454 < <cons sem="G#protein_molecule">Protein kinase C</cons> is not a downstream effector of <cons sem="G#DNA_domain_or_region">p21ras</cons> in <cons sem="G#cell_type">activated T cells</cons>. --- > > <sentence><cons sem="G#protein_molecule">Protein kinase C</cons> is not a downstream effector of <cons sem="G#DNA_domain_or_region">p21ras</cons> in <cons sem="G#cell_type">activated T cells</cons>.</sentence> > 2210c2458 < Data is presented, using the potent and selective PKC inhibitor Ro 31-8425 and transient expression of a constitutively active ras mutant, which clearly shows that PKC is not downstream of p21ras in the induction of NF-AT and AP-1 transcriptional activity and in the expression of IL-2 in human Jurkat T cells. --- > Data is presented, using the potent and selective PKC inhibitor Ro 31-8425 and transient expression of a constitutively active ras mutant, which clearly shows that PKC is not downstream of p21ras in the induction of NF-AT and AP-1 transcriptional activity and in the expression of IL-2 in human Jurkat T cells. 2212c2460 < The signaling pathways involving PKC activation, calcium mobilization and ras activation combine to provide the necessary components for production of IL-2 during T cell activation. --- > The signaling pathways involving PKC activation, calcium mobilization and ras activation combine to provide the necessary components for production of IL-2 during T cell activation. 2220c2468,2470 < The <cons sem="G#protein_domain_or_region">C-terminus</cons> of the <cons sem="G#protein_domain_or_region">B cell activator</cons> <cons sem="G#protein_molecule">Oct-2</cons> functions as an <cons sem="G#protein_domain_or_region">activation domain</cons> in <cons sem="G#mono_cell">yeast</cons>. --- > > <sentence>The <cons sem="G#protein_domain_or_region">C-terminus</cons> of the <cons sem="G#protein_domain_or_region">B cell activator</cons> <cons sem="G#protein_molecule">Oct-2</cons> functions as an <cons sem="G#protein_domain_or_region">activation domain</cons> in <cons sem="G#mono_cell">yeast</cons>.</sentence> > 2224c2474 < Transfer of the Oct-2 C-terminal domain onto either Oct-1 (Oct1.2) or a nonactivating DNA-binding domain from GAL4 created activators capable of greater than 15 and 10-fold stimulation of activity, respectively. --- > Transfer of the Oct-2 C-terminal domain onto either Oct-1 (Oct1.2) or a nonactivating DNA-binding domain from GAL4 created activators capable of greater than 15 and 10-fold stimulation of activity, respectively. 2233c2483,2485 < <cons sem="G#other_name">Glucocorticoid-induced apoptosis</cons> of <cons sem="G#cell_type">lymphoid cells</cons>. --- > > <sentence><cons sem="G#other_name">Glucocorticoid-induced apoptosis</cons> of <cons sem="G#cell_type">lymphoid cells</cons>.</sentence> > 2246c2498,2500 < <cons sem="G#protein_molecule">Interleukin-2</cons> induces <cons sem="G#other_name"><cons sem="G#amino_acid_monomer">tyrosine</cons> phosphorylation</cons> and <cons sem="G#other_name">nuclear translocation</cons> of <cons sem="G#protein_molecule">stat3</cons> in <cons sem="G#cell_type">human T <cons sem="G#cell_type">lymphocytes</cons></cons>. --- > > <sentence><cons sem="G#protein_molecule">Interleukin-2</cons> induces <cons sem="G#other_name"><cons sem="G#amino_acid_monomer">tyrosine</cons> phosphorylation</cons> and <cons sem="G#other_name">nuclear translocation</cons> of <cons sem="G#protein_molecule">stat3</cons> in <cons sem="G#cell_type">human T <cons sem="G#cell_type">lymphocytes</cons></cons>.</sentence> > 2251c2505 < In contrast, stat1 proteins were not tyrosine phosphorylated after IL-2 ligation, whereas tyrosine- phosphorylated stat1 proteins (91 and 84 kDa proteins) were translocated to the nucleus following interferon-gamma treatment of HeLa cells. --- > In contrast, stat1 proteins were not tyrosine phosphorylated after IL-2 ligation, whereas tyrosine- phosphorylated stat1 proteins (91 and 84 kDa proteins) were translocated to the nucleus following interferon-gamma treatment of HeLa cells. 2263c2517,2519 < <cons sem="G#other_name">Human <cons sem="G#virus">T-cell leukemia virus type I</cons> <cons sem="G#protein_molecule">Tax</cons> activation</cons> of <cons sem="G#protein_molecule"><cons sem="G#protein_molecule">NF-kappa B</cons>/Rel</cons> involves phosphorylation and degradation of <cons sem="G#protein_molecule">I kappa B alpha</cons> and <cons sem="G#protein_molecule">RelA</cons> <cons sem="G#other_name">(<cons sem="G#protein_subunit">p65</cons>)-mediated induction</cons> of the <cons sem="G#DNA_domain_or_region">c-rel gene</cons>. --- > > <sentence><cons sem="G#other_name">Human <cons sem="G#virus">T-cell leukemia virus type I</cons> <cons sem="G#protein_molecule">Tax</cons> activation</cons> of <cons sem="G#protein_molecule"><cons sem="G#protein_molecule">NF-kappa B</cons>/Rel</cons> involves phosphorylation and degradation of <cons sem="G#protein_molecule">I kappa B alpha</cons> and <cons sem="G#protein_molecule">RelA</cons> <cons sem="G#other_name">(<cons sem="G#protein_subunit">p65</cons>)-mediated induction</cons> of the <cons sem="G#DNA_domain_or_region">c-rel gene</cons>.</sentence> > 2265c2521 < The tax gene product of human T-cell leukemia virus type I (HTLV-I) is a potent transcriptional activator that both stimulates viral gene expression and activates an array of cellular genes involved in T-cell growth. --- > The tax gene product of human T-cell leukemia virus type I (HTLV-I) is a potent transcriptional activator that both stimulates viral gene expression and activates an array of cellular genes involved in T-cell growth. 2281c2537,2539 < Activation of <cons sem="G#protein_molecule">NF-kappa B</cons> in vivo is regulated by multiple phosphorylations. --- > > <sentence>Activation of <cons sem="G#protein_molecule">NF-kappa B</cons> in vivo is regulated by multiple phosphorylations.</sentence> > 2301c2559,2561 < Treatment of <cons sem="G#cell_line">HL60 cells</cons> with various combinations of <cons sem="G#other_organic_compound">retinoids</cons> and <cons sem="G#lipid">1 alpha,25 dihydroxyvitamin D3</cons> results in differentiation towards <cons sem="G#cell_type">neutrophils</cons> or <cons sem="G#cell_type">monocytes</cons> or a failure to differentiate and <cons sem="G#other_name">apoptosis</cons>. --- > > <sentence>Treatment of <cons sem="G#cell_line">HL60 cells</cons> with various combinations of <cons sem="G#other_organic_compound">retinoids</cons> and <cons sem="G#lipid">1 alpha,25 dihydroxyvitamin D3</cons> results in differentiation towards <cons sem="G#cell_type">neutrophils</cons> or <cons sem="G#cell_type">monocytes</cons> or a failure to differentiate and <cons sem="G#other_name">apoptosis</cons>.</sentence> > 2319c2579,2581 < Isolation of differentially expressed sequence tags from <cons sem="G#cell_type">steroid- responsive cells</cons> using <cons sem="G#other_name"><cons sem="G#RNA_family_or_group">mRNA</cons> differential display</cons>. --- > > <sentence>Isolation of differentially expressed sequence tags from <cons sem="G#cell_type">steroid- responsive cells</cons> using <cons sem="G#other_name"><cons sem="G#RNA_family_or_group">mRNA</cons> differential display</cons>.</sentence> > 2323c2585 < In this paper we describe results using mRNA differential display reverse transcriptase PCR (DDPCR) to identify and isolate short cDNA sequence tags from thymocyte and prostate cells under various hormone conditions. --- > In this paper we describe results using mRNA differential display reverse transcriptase PCR (DDPCR) to identify and isolate short cDNA sequence tags from thymocyte and prostate cells under various hormone conditions. 2336c2598,2600 < Activation of <cons sem="G#cell_type">human thymocytes</cons> after infection by <cons sem="G#virus">EBV</cons>. --- > > <sentence>Activation of <cons sem="G#cell_type">human thymocytes</cons> after infection by <cons sem="G#virus">EBV</cons>.</sentence> > 2357c2621,2623 < Effects of <cons sem="G#lipid">intranasal glucocorticoids</cons> on <cons sem="(AND G#other_name G#other_name)"><cons>endogenous glucocorticoid</cons> <cons>peripheral</cons> and <cons>central</cons> <cons>function</cons></cons>. --- > > <sentence>Effects of <cons sem="G#lipid">intranasal glucocorticoids</cons> on <cons sem="(AND G#other_name G#other_name)"><cons>endogenous glucocorticoid</cons> <cons>peripheral</cons> and <cons>central</cons> <cons>function</cons></cons>.</sentence> > 2363c2629 < Serum cortisol, osteocalcin and urinary cortisol levels were also determined. --- > Serum cortisol, osteocalcin and urinary cortisol levels were also determined. 2379c2645,2647 < Biphasic control of <cons sem="G#other_name"><cons sem="G#protein_molecule">nuclear factor-kappa B</cons> activation</cons> by the <cons sem="G#protein_complex">T cell receptor complex</cons>: role of <cons sem="G#protein_molecule">tumor necrosis factor alpha</cons>. --- > > <sentence>Biphasic control of <cons sem="G#other_name"><cons sem="G#protein_molecule">nuclear factor-kappa B</cons> activation</cons> by the <cons sem="G#protein_complex">T cell receptor complex</cons>: role of <cons sem="G#protein_molecule">tumor necrosis factor alpha</cons>.</sentence> > 2399c2667,2669 < The <cons sem="G#protein_molecule">transcription factor <cons sem="G#protein_molecule">Sp1</cons></cons> is required for induction of the <cons sem="G#DNA_domain_or_region">murine GM- CSF promoter</cons> in <cons sem="G#cell_type">T cells</cons>. --- > > <sentence>The <cons sem="G#protein_molecule">transcription factor <cons sem="G#protein_molecule">Sp1</cons></cons> is required for induction of the <cons sem="G#DNA_domain_or_region">murine GM- CSF promoter</cons> in <cons sem="G#cell_type">T cells</cons>.</sentence> > 2405c2675 < We show that depletion of Sp1 (A1) from nuclear extracts specifically decreases in vitro transcription activity on GM-CSF templates. --- > We show that depletion of Sp1 (A1) from nuclear extracts specifically decreases in vitro transcription activity on GM-CSF templates. 2414c2684,2686 < A factor that regulates the <cons sem="G#DNA_family_or_group">class II major histocompatibility complex gene</cons> <cons sem="G#DNA_domain_or_region">DPA</cons> is a member of a subfamily of <cons sem="G#protein_family_or_group">zinc finger proteins</cons> that includes a <cons sem="G#protein_family_or_group">Drosophila developmental control protein</cons>. --- > > <sentence>A factor that regulates the <cons sem="G#DNA_family_or_group">class II major histocompatibility complex gene</cons> <cons sem="G#DNA_domain_or_region">DPA</cons> is a member of a subfamily of <cons sem="G#protein_family_or_group">zinc finger proteins</cons> that includes a <cons sem="G#protein_family_or_group">Drosophila developmental control protein</cons>.</sentence> > 2417c2689 < To study this element and its role in class II gene regulation further, a cDNA library was screened with oligonucleotide probes containing both the S element and the nearby J element of the human DPA gene. --- > To study this element and its role in class II gene regulation further, a cDNA library was screened with oligonucleotide probes containing both the S element and the nearby J element of the human DPA gene. 2432c2704,2706 < Separation of oxidant-initiated and redox-regulated steps in the <cons sem="G#other_name">NF- kappa B signal transduction pathway</cons>. --- > > <sentence>Separation of oxidant-initiated and redox-regulated steps in the <cons sem="G#other_name"><cons sem="G#protein_molecule">NF- kappa B</cons> signal transduction pathway</cons>.</sentence> > 2439c2713 < Since internal sites of oxidant production have been shown to play a key role in the cytokine-stimulated activation of NF-kappa B, and since tyrosine kinase and phosphatase activities are known to be altered by oxidants, these findings suggest that intracellular redox status controls NF-kappa B activation by regulating tyrosine phosphorylation event(s) within the common step of the NF-kappa B signal transduction pathway. --- > Since internal sites of oxidant production have been shown to play a key role in the cytokine-stimulated activation of NF-kappa B, and since tyrosine kinase and phosphatase activities are known to be altered by oxidants, these findings suggest that intracellular redox status controls NF-kappa B activation by regulating tyrosine phosphorylation event(s) within the common step of the NF-kappa B signal transduction pathway. 2447c2721,2723 < Deleted <cons sem="G#DNA_molecule">chromosome 20</cons> from a <cons sem="G#multi_cell">patient</cons> with <cons sem="G#other_name">Alagille syndrome</cons> isolated in a cell hybrid through <cons sem="G#other_name">leucine transport selection</cons>: study of three candidate genes. --- > > <sentence>Deleted <cons sem="G#DNA_molecule">chromosome 20</cons> from a <cons sem="G#multi_cell">patient</cons> with <cons sem="G#other_name">Alagille syndrome</cons> isolated in a cell hybrid through <cons sem="G#other_name"><cons sem="G#amino_acid_monomer">leucine</cons> transport selection</cons>: study of three candidate genes.</sentence> > 2451c2727 < This hybrid clone, designated NR2, was characterized by several methods, including PCR, with eight pairs of oligonucleotides mapped to Chr 20: D20S5, D20S41, D20S42, D20S56, D20S57, D20S58, adenosine deaminase (ADA), and Prion protein (PRIP); Restriction Fragment Length Polymorphism (RFLP) analyses with four genomic anonymous probes (D20S5, cD3H12, D20S17, D20S18); and fluorescent in situ hybridization (FISH) with total human DNA and D20Z1, a sequence specific to the human Chr 20 centromere, as probes. --- > This hybrid clone, designated NR2, was characterized by several methods, including PCR, with eight pairs of oligonucleotides mapped to Chr 20: D20S5, D20S41, D20S42, D20S56, D20S57, D20S58, adenosine deaminase (ADA), and Prion protein (PRIP); Restriction Fragment Length Polymorphism (RFLP) analyses with four genomic anonymous probes (D20S5, cD3H12, D20S17, D20S18); and fluorescent in situ hybridization (FISH) with total human DNA and D20Z1, a sequence specific to the human Chr 20 centromere, as probes. 2462c2738,2740 < <cons sem="(AND G#other_name G#other_name)"><cons>Positive</cons> and <cons>negative</cons> <cons>regulation</cons></cons> of the <cons sem="G#DNA_domain_or_region">composite octamer motif</cons> of the <cons sem="G#DNA_domain_or_region">interleukin 2 enhancer</cons> by <cons sem="G#protein_molecule">AP-1</cons>, <cons sem="G#protein_molecule">Oct-2</cons>, and <cons sem="G#protein_molecule">retinoic acid receptor</cons>. --- > > <sentence><cons sem="(AND G#other_name G#other_name)"><cons>Positive</cons> and <cons>negative</cons> <cons>regulation</cons></cons> of the <cons sem="G#DNA_domain_or_region">composite octamer motif</cons> of the <cons sem="G#DNA_domain_or_region">interleukin 2 enhancer</cons> by <cons sem="G#protein_molecule">AP-1</cons>, <cons sem="G#protein_molecule">Oct-2</cons>, and <cons sem="G#protein_molecule">retinoic acid receptor</cons>.</sentence> > 2473c2751 < Furthermore, retinoic acid receptor (RAR) alpha is able to inhibit in vitro the formation of the complex between the nuclear AP-1/OAP and its specific binding site, resulting in the interference with Oct-2-dependent cis-regulatory function of this AP-1 element. --- > Furthermore, retinoic acid receptor (RAR) alpha is able to inhibit in vitro the formation of the complex between the nuclear AP-1/OAP and its specific binding site, resulting in the interference with Oct-2-dependent cis-regulatory function of this AP-1 element. 2482c2760,2762 < <cons sem="G#other_name">Missense mutation</cons> in <cons sem="G#DNA_domain_or_region">exon 7</cons> of the <cons sem="G#DNA_domain_or_region">common gamma chain gene</cons> causes a moderate form of <cons sem="G#other_name">X-linked combined immunodeficiency</cons>. --- > > <sentence><cons sem="G#other_name">Missense mutation</cons> in <cons sem="G#DNA_domain_or_region">exon 7</cons> of the <cons sem="G#DNA_domain_or_region">common gamma chain gene</cons> causes a moderate form of <cons sem="G#other_name">X-linked combined immunodeficiency</cons>.</sentence> > 2499c2779,2781 < <cons sem="G#other_name">Posttranscriptional regulation</cons> of <cons sem="G#other_name">macrophage tissue factor expression</cons> by <cons sem="G#other_organic_compound">antioxidants</cons>. --- > > <sentence><cons sem="G#other_name">Posttranscriptional regulation</cons> of <cons sem="G#other_name">macrophage <cons sem="G#protein_family_or_group">tissue factor</cons> expression</cons> by <cons sem="G#other_organic_compound">antioxidants</cons>.</sentence> > 2519c2801,2803 < Characterization of the <cons sem="G#DNA_domain_or_region">CD48 gene</cons> demonstrates a positive element that is specific to <cons sem="G#cell_type"><cons sem="G#virus">Epstein-Barr virus</cons>-immortalized B-cell lines</cons> and contains an essential <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">NF-kappa B</cons> site</cons>. --- > > <sentence>Characterization of the <cons sem="G#DNA_domain_or_region">CD48 gene</cons> demonstrates a positive element that is specific to <cons sem="G#cell_type"><cons sem="G#virus">Epstein-Barr virus</cons>-immortalized B-cell lines</cons> and contains an essential <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">NF-kappa B</cons> site</cons>.</sentence> > 2534c2818,2820 < <cons sem="G#other_organic_compound">Thapsigargin</cons> induces <cons sem="G#protein_subunit">IL-2 receptor alpha-chain</cons> in <cons sem="G#cell_type">human peripheral</cons> and <cons sem="G#cell_line">Jurkat T cells</cons> via a <cons sem="G#other_name"><cons sem="G#protein_molecule">protein kinase C</cons>-independent mechanism</cons>. --- > > <sentence><cons sem="G#other_organic_compound">Thapsigargin</cons> induces <cons sem="G#protein_subunit">IL-2 receptor alpha-chain</cons> in <cons sem="G#cell_type">human peripheral</cons> and <cons sem="G#cell_line">Jurkat T cells</cons> via a <cons sem="G#other_name"><cons sem="G#protein_molecule">protein kinase C</cons>-independent mechanism</cons>.</sentence> > 2543c2829 < In toto, these results suggest that TG induces IL-2R alpha in human T cells through a PKC-independent pathway. --- > In toto, these results suggest that TG induces IL-2R alpha in human T cells through a PKC-independent pathway. 2551c2837,2839 < Physiological concentration of <cons sem="G#lipid">estradiol</cons> inhibits <cons sem="G#other_name"><cons sem="G#cell_type">polymorphonuclear leukocyte</cons> chemotaxis</cons> via a receptor mediated system. --- > > <sentence>Physiological concentration of <cons sem="G#lipid">estradiol</cons> inhibits <cons sem="G#other_name"><cons sem="G#cell_type">polymorphonuclear leukocyte</cons> chemotaxis</cons> via a receptor mediated system.</sentence> > 2569c2857,2859 < Identification of the <cons sem="G#DNA_domain_or_region">TCL1 gene</cons> involved in <cons sem="G#other_name"><cons sem="G#cell_type">T-cell</cons> malignancies</cons>. --- > > <sentence>Identification of the <cons sem="G#DNA_domain_or_region">TCL1 gene</cons> involved in <cons sem="G#other_name"><cons sem="G#cell_type">T-cell</cons> malignancies</cons>.</sentence> > 2583c2873,2875 < Identification of a region which directs the <cons sem="G#other_name">monocytic activity</cons> of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">colony-stimulating factor 1</cons> (<cons sem="G#protein_molecule">macrophage colony-stimulating factor</cons>) <cons sem="G#DNA_domain_or_region">receptor promoter</cons></cons> and binds <cons sem="G#protein_molecule">PEBP2/CBF</cons> (<cons sem="G#protein_molecule">AML1</cons>). --- > > <sentence>Identification of a region which directs the <cons sem="G#other_name">monocytic activity</cons> of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">colony-stimulating factor 1</cons> (<cons sem="G#protein_molecule">macrophage colony-stimulating factor</cons>) <cons sem="G#DNA_domain_or_region">receptor promoter</cons></cons> and binds <cons sem="G#protein_molecule">PEBP2/CBF</cons> (<cons sem="G#protein_molecule">AML1</cons>).</sentence> > 2588c2880 < When analyzed by DNase footprinting, region II was protected preferentially in monocytic cells. --- > When analyzed by DNase footprinting, region II was protected preferentially in monocytic cells. 2602c2894,2896 < <cons sem="G#other_organic_compound">Pyrrolidine dithiocarbamate</cons>, a potent inhibitor of <cons sem="G#protein_molecule">nuclear factor kappa B</cons> (<cons sem="G#protein_molecule">NF-kappa B</cons>) activation, prevents apoptosis in human <cons sem="G#cell_line">promyelocytic leukemia HL-60 cells</cons> and <cons sem="G#cell_type">thymocytes</cons>. --- > > <sentence><cons sem="G#other_organic_compound">Pyrrolidine dithiocarbamate</cons>, a potent inhibitor of <cons sem="G#protein_molecule">nuclear factor kappa B</cons> (<cons sem="G#protein_molecule">NF-kappa B</cons>) activation, prevents apoptosis in human <cons sem="G#cell_line">promyelocytic leukemia HL-60 cells</cons> and <cons sem="G#cell_type">thymocytes</cons>.</sentence> > 2606c2900 < The simultaneous addition of 50-500 microM PDTC with these agents blocked NF-kappa B activation and completely abrogated both morphologically apoptotic changes and internucleosomal DNA fragmentation for up to 6 hr. --- > The simultaneous addition of 50-500 microM PDTC with these agents blocked NF-kappa B activation and completely abrogated both morphologically apoptotic changes and internucleosomal DNA fragmentation for up to 6 hr. 2619c2913,2915 < Overexpression of <cons sem="G#protein_molecule"><cons sem="G#protein_molecule">protein kinase C</cons>-zeta</cons> stimulates <cons sem="G#other_name"><cons sem="G#cell_type">leukemic cell</cons> differentiation</cons>. --- > > <sentence>Overexpression of <cons sem="G#protein_molecule"><cons sem="G#protein_molecule">protein kinase C</cons>-zeta</cons> stimulates <cons sem="G#other_name"><cons sem="G#cell_type">leukemic cell</cons> differentiation</cons>.</sentence> > 2623c2919 < PKC-zeta cells expressed a more differentiated phenotype as assessed by changes in morphology, surface antigen expression, and lysosomal enzyme activities and were distinct from parental U937 cells stimulated to differentiate by exposure to phorbol esters. --- > PKC-zeta cells expressed a more differentiated phenotype as assessed by changes in morphology, surface antigen expression, and lysosomal enzyme activities and were distinct from parental U937 cells stimulated to differentiate by exposure to phorbol esters. 2634c2930,2932 < A family of <cons sem="G#protein_family_or_group">serine proteases</cons> expressed exclusively in myelo-<cons sem="G#cell_type">monocytic cells</cons> specifically processes the <cons sem="G#protein_subunit">nuclear factor-kappa B subunit p65</cons> in vitro and may impair human <cons sem="G#other_name"><cons sem="G#virus">immunodeficiency virus</cons> replication</cons> in these cells. --- > > <sentence>A family of <cons sem="G#protein_family_or_group">serine proteases</cons> expressed exclusively in myelo-<cons sem="G#cell_type">monocytic cells</cons> specifically processes the <cons sem="G#protein_subunit">nuclear factor-kappa B subunit p65</cons> in vitro and may impair human <cons sem="G#other_name"><cons sem="G#virus">immunodeficiency virus</cons> replication</cons> in these cells.</sentence> > 2636c2934 < Two groups of U937 promonocytic cells were obtained by limiting dilution cloning which differed strikingly in their ability to support human immunodeficiency virus 1 (HIV-1) replication. --- > Two groups of U937 promonocytic cells were obtained by limiting dilution cloning which differed strikingly in their ability to support human immunodeficiency virus 1 (HIV-1) replication. 2655c2953,2955 < A <cons sem="G#DNA_domain_or_region">germline TaqI restriction fragment length polymorphism</cons> in the <cons sem="G#DNA_domain_or_region">progesterone receptor gene</cons> in <cons sem="G#other_name">ovarian carcinoma</cons> [see comments] --- > > <sentence>A <cons sem="G#DNA_domain_or_region">germline TaqI restriction fragment length polymorphism</cons> in the <cons sem="G#DNA_domain_or_region">progesterone receptor gene</cons> in <cons sem="G#other_name">ovarian carcinoma</cons> [see comments]</sentence> > 2671c2971,2973 < <cons sem="G#protein_molecule">OBF-1</cons>, a <cons sem="G#protein_family_or_group">novel B cell-specific coactivator</cons> that stimulates <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">immunoglobulin promoter</cons> activity</cons> through association with <cons sem="G#protein_family_or_group">octamer- binding proteins</cons>. --- > > <sentence><cons sem="G#protein_molecule">OBF-1</cons>, a <cons sem="G#protein_family_or_group">novel B cell-specific coactivator</cons> that stimulates <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">immunoglobulin promoter</cons> activity</cons> through association with <cons sem="G#protein_family_or_group">octamer- binding proteins</cons>.</sentence> > 2686c2988,2990 < Modulation of <cons sem="G#other_name"><cons sem="G#protein_molecule">transcription factor <cons sem="G#protein_molecule">NF kappa B</cons></cons> activity</cons> by <cons sem="G#other_name">intracellular <cons sem="G#peptide">glutathione</cons> levels</cons> and by variations of the <cons sem="G#other_name">extracellular <cons sem="G#amino_acid_monomer">cysteine</cons> supply</cons>. --- > > <sentence>Modulation of <cons sem="G#other_name"><cons sem="G#protein_molecule">transcription factor <cons sem="G#protein_molecule">NF kappa B</cons></cons> activity</cons> by <cons sem="G#other_name">intracellular <cons sem="G#peptide">glutathione</cons> levels</cons> and by variations of the <cons sem="G#other_name">extracellular <cons sem="G#amino_acid_monomer">cysteine</cons> supply</cons>.</sentence> > 2699c3003,3005 < Two distinct signalling pathways are involved in the control of the <cons sem="G#other_name">biphasic <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">junB</cons> transcription</cons></cons> induced by <cons sem="G#protein_molecule">interleukin-6</cons> in the <cons sem="G#cell_line">B cell hybridoma 7TD1</cons>. --- > > <sentence>Two distinct signalling pathways are involved in the control of the <cons sem="G#other_name">biphasic <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">junB</cons> transcription</cons></cons> induced by <cons sem="G#protein_molecule">interleukin-6</cons> in the <cons sem="G#cell_line">B cell hybridoma 7TD1</cons>.</sentence> > 2706c3012 < In this study, we demonstrated that IL-6 regulation occurred exclusively at the transcriptional level and that the bimodal increase of junB mRNA and JunB protein can be accounted for by a biphasic stimulation of junB transcription. --- > In this study, we demonstrated that IL-6 regulation occurred exclusively at the transcriptional level and that the bimodal increase of junB mRNA and JunB protein can be accounted for by a biphasic stimulation of junB transcription. 2719c3025,3027 < A newly established <cons sem="G#cell_line">megakaryoblastic/erythroid cell line</cons> that differentiates to <cons sem="G#cell_type">red cells</cons> in the presence of <cons sem="G#protein_molecule">erythropoietin</cons> and produces <cons sem="G#cell_type">platelet-like particles</cons>. --- > > <sentence>A newly established <cons sem="G#cell_line">megakaryoblastic/erythroid cell line</cons> that differentiates to <cons sem="G#cell_type">red cells</cons> in the presence of <cons sem="G#protein_molecule">erythropoietin</cons> and produces <cons sem="G#cell_type">platelet-like particles</cons>.</sentence> > 2728c3036 < These benzidine-positive cells were positive for hemoglobin F staining. --- > These benzidine-positive cells were positive for hemoglobin F staining. 2739c3047,3049 < Differential regulation of <cons sem="G#DNA_family_or_group">proto-oncogenes</cons> <cons sem="G#DNA_domain_or_region">c-jun</cons> and <cons sem="G#DNA_domain_or_region">c-fos</cons> in <cons sem="G#cell_type">T lymphocytes</cons> activated through <cons sem="G#protein_molecule">CD28</cons>. --- > > <sentence>Differential regulation of <cons sem="G#DNA_family_or_group">proto-oncogenes</cons> <cons sem="G#DNA_domain_or_region">c-jun</cons> and <cons sem="G#DNA_domain_or_region">c-fos</cons> in <cons sem="G#cell_type">T lymphocytes</cons> activated through <cons sem="G#protein_molecule">CD28</cons>.</sentence> > 2755c3065,3067 < Enhanced responsiveness to <cons sem="G#protein_molecule">nuclear factor kappa B</cons> contributes to the unique phenotype of <cons sem="G#virus">simian immunodeficiency virus variant</cons> <cons sem="G#virus">SIVsmmPBj14</cons>. --- > > <sentence>Enhanced responsiveness to <cons sem="G#protein_molecule">nuclear factor kappa B</cons> contributes to the unique phenotype of <cons sem="G#virus">simian immunodeficiency virus variant</cons> <cons sem="G#virus">SIVsmmPBj14</cons>.</sentence> > 2775c3087,3089 < Constitutive <cons sem="G#protein_molecule">nuclear NF-kappa B</cons> in cells of the monocyte lineage. --- > > <sentence>Constitutive <cons sem="G#protein_molecule">nuclear NF-kappa B</cons> in cells of the monocyte lineage.</sentence> > 2799c3113,3115 < <cons sem="G#protein_molecule">Steel factor</cons> affects <cons sem="G#other_name">SCL expression</cons> during normal <cons sem="G#other_name">erythroid differentiation</cons>. --- > > <sentence><cons sem="G#protein_molecule">Steel factor</cons> affects <cons sem="G#other_name"><cons sem="G#protein_molecule">SCL</cons> expression</cons> during normal <cons sem="G#other_name">erythroid differentiation</cons>.</sentence> > 2818c3134,3136 < <cons sem="G#other_name">C/EBP beta regulation</cons> of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">tumor necrosis factor alpha</cons> gene</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#protein_molecule">C/EBP beta</cons> regulation</cons> of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">tumor necrosis factor alpha</cons> gene</cons>.</sentence> > 2834c3152,3154 < <cons sem="G#protein_molecule">Calcium/calmodulin-dependent protein kinase II</cons> downregulates both <cons sem="(AND G#other_name G#other_name)"><cons>calcineurin</cons> and <cons>protein kinase C</cons><cons>-mediated pathways</cons></cons> for <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region"><cons sem="G#protein_family_or_group">cytokine</cons> gene</cons> transcription</cons> in <cons sem="G#cell_type">human T cells</cons>. --- > > <sentence><cons sem="G#protein_molecule">Calcium/calmodulin-dependent protein kinase II</cons> downregulates both <cons sem="(AND G#other_name G#other_name)"><cons>calcineurin</cons> and <cons>protein kinase C</cons><cons>-mediated pathways</cons></cons> for <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region"><cons sem="G#protein_family_or_group">cytokine</cons> gene</cons> transcription</cons> in <cons sem="G#cell_type">human T cells</cons>.</sentence> > 2856c3176,3178 < Induction of <cons sem="G#protein_molecule">ICAM-1</cons> and <cons sem="G#protein_molecule">LFA-3</cons> by <cons sem="G#protein_molecule">Tax1</cons> of human <cons sem="G#virus">T-cell leukemia virus type 1</cons> and mechanism of down-regulation of <cons sem="G#protein_molecule">ICAM-1</cons> or <cons sem="G#protein_molecule">LFA-1</cons> in <cons sem="G#cell_line">adult-T- cell-leukemia cell lines</cons>. --- > > <sentence>Induction of <cons sem="G#protein_molecule">ICAM-1</cons> and <cons sem="G#protein_molecule">LFA-3</cons> by <cons sem="G#protein_molecule">Tax1</cons> of human <cons sem="G#virus">T-cell leukemia virus type 1</cons> and mechanism of down-regulation of <cons sem="G#protein_molecule">ICAM-1</cons> or <cons sem="G#protein_molecule">LFA-1</cons> in <cons sem="G#cell_line">adult-T- cell-leukemia cell lines</cons>.</sentence> > 2869c3191 < No genomic changes were found, and a CAT reporter gene with the CD18 promoter was inactive in the 3 of them, again suggesting lack of (a) transcriptional factor(s) necessary for CD18 expression. --- > No genomic changes were found, and a CAT reporter gene with the CD18 promoter was inactive in the 3 of them, again suggesting lack of (a) transcriptional factor(s) necessary for CD18 expression. 2877c3199,3201 < Infection with <cons sem="G#mono_cell">Theileria annulata</cons> induces expression of <cons sem="G#protein_molecule">matrix metalloproteinase 9</cons> and <cons sem="G#protein_family_or_group">transcription factor</cons> <cons sem="G#protein_molecule">AP-1</cons> in <cons sem="G#cell_type">bovine leucocytes</cons>. --- > > <sentence>Infection with <cons sem="G#mono_cell">Theileria annulata</cons> induces expression of <cons sem="G#protein_molecule">matrix metalloproteinase 9</cons> and <cons sem="G#protein_family_or_group">transcription factor</cons> <cons sem="G#protein_molecule">AP-1</cons> in <cons sem="G#cell_type">bovine leucocytes</cons>.</sentence> > 2881c3205 < T. annulata-infected leucocytes produce a number of novel metalloproteinase activities. --- > T. annulata-infected leucocytes produce a number of novel metalloproteinase activities. 2896c3220,3222 < <cons sem="G#other_name"><cons sem="G#cell_type">B-cell</cons> proliferation</cons> and induction of early <cons sem="G#protein_family_or_group">G1-regulating proteins</cons> by <cons sem="G#virus">Epstein-Barr virus mutants</cons> conditional for <cons sem="G#protein_molecule">EBNA2</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#cell_type">B-cell</cons> proliferation</cons> and induction of early <cons sem="G#protein_family_or_group">G1-regulating proteins</cons> by <cons sem="G#virus">Epstein-Barr virus mutants</cons> conditional for <cons sem="G#protein_molecule">EBNA2</cons>.</sentence> > 2915c3241,3243 < <cons sem="G#protein_molecule">IL-1 receptor</cons> and <cons sem="G#other_name">TCR signals</cons> synergize to activate <cons sem="G#other_name"><cons sem="G#protein_molecule">NF-kappa B</cons>-mediated gene transcription</cons>. --- > > <sentence><cons sem="G#protein_molecule">IL-1 receptor</cons> and <cons sem="G#other_name"><cons sem="G#protein_family_or_group">TCR</cons> signals</cons> synergize to activate <cons sem="G#other_name"><cons sem="G#protein_molecule">NF-kappa B</cons>-mediated gene transcription</cons>.</sentence> > 2917c3245 < Previous studies have demonstrated that IL-1 receptor (IL-1R)- and TCR- initiated signals can interact synergistically to increase the rate of transcription of several lymphokine and lymphokine receptor genes during the competence phase of the activation program in T helper lymphocytes. --- > Previous studies have demonstrated that IL-1 receptor (IL-1R)- and TCR- initiated signals can interact synergistically to increase the rate of transcription of several lymphokine and lymphokine receptor genes during the competence phase of the activation program in T helper lymphocytes. 2919,2920c3247,3248 < The synergistic antigen receptor initiated signals are mediated through protein kinase C because they can be mimicked by the phorbol ester, 12- O-tetradecanoylphorbol-13-acetate, but not with calcium ionophores; and are staurosporine sensitive but cyclosporine resistant. < Gel shift analyses demonstrate that NF-kappa B nuclear translocation is stimulated primarily by IL-1 rather than by antigen receptor signals. --- > The synergistic antigen receptor initiated signals are mediated through protein kinase C because they can be mimicked by the phorbol ester, 12- O-tetradecanoylphorbol-13-acetate, but not with calcium ionophores; and are staurosporine sensitive but cyclosporine resistant. > Gel shift analyses demonstrate that NF-kappa B nuclear translocation is stimulated primarily by IL-1 rather than by antigen receptor signals. 2932c3260,3262 < Identification of the <cons sem="G#DNA_domain_or_region">promoter region</cons> of <cons sem="G#virus">chicken anemia virus</cons> (<cons sem="G#virus">CAV</cons>) containing a novel <cons sem="G#DNA_family_or_group">enhancer-like element</cons>. --- > > <sentence>Identification of the <cons sem="G#DNA_domain_or_region">promoter region</cons> of <cons sem="G#virus">chicken anemia virus</cons> (<cons sem="G#virus">CAV</cons>) containing a novel <cons sem="G#DNA_family_or_group">enhancer-like element</cons>.</sentence> > 2934c3264 < The single promoter region in the cloned genome [Noteborn et al., J. Virol. 65 (1991) 3131-3139] of chicken anemia virus (CAV) in chicken T- cells was analysed via CAT assays. --- > The single promoter region in the cloned genome [Noteborn et al., J. Virol. 65 (1991) 3131-3139] of chicken anemia virus (CAV) in chicken T- cells was analysed via CAT assays. 2948c3278,3280 < Functional <cons sem="G#protein_complex">Myc-Max heterodimer</cons> is required for activation-induced <cons sem="G#other_name">apoptosis</cons> in <cons sem="G#cell_line">T cell hybridomas</cons>. --- > > <sentence>Functional <cons sem="G#protein_complex">Myc-Max heterodimer</cons> is required for activation-induced <cons sem="G#other_name">apoptosis</cons> in <cons sem="G#cell_line">T cell hybridomas</cons>.</sentence> > 2962c3294,3296 < <cons sem="G#protein_molecule"><cons sem="G#virus">Epstein-Barr virus</cons> SM protein</cons>. --- > > <sentence><cons sem="G#protein_molecule"><cons sem="G#virus">Epstein-Barr virus</cons> SM protein</cons>.</sentence> > 2978c3312,3314 < Inducible binding to the c-fos serum response element during <cons sem="G#other_name">T cell activation</cons> is regulated by a <cons sem="G#protein_family_or_group">phosphotyrosine-containing protein</cons>. --- > > <sentence>Inducible binding to the c-fos serum response element during <cons sem="G#other_name">T cell activation</cons> is regulated by a <cons sem="G#protein_family_or_group">phosphotyrosine-containing protein</cons>.</sentence> > 2995c3331,3333 < In vivo modification of <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region"><cons sem="G#protein_complex">major histocompatibility complex class II</cons> DRA promoter</cons> occupancy</cons> mediated by the <cons sem="G#protein_molecule">AIR-1 trans-activator</cons>. --- > > <sentence>In vivo modification of <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region"><cons sem="G#protein_complex">major histocompatibility complex class II</cons> DRA promoter</cons> occupancy</cons> mediated by the <cons sem="G#protein_molecule">AIR-1 trans-activator</cons>.</sentence> > 2999c3337 < Here we show, by in vivo DNase I footprinting, that the AIR-1 locus defect correlates with changes in the DRA promoter occupancy. --- > Here we show, by in vivo DNase I footprinting, that the AIR-1 locus defect correlates with changes in the DRA promoter occupancy. 3003c3341 < Thus, the use of DNase I allowed us, for the first time, to correlate the AIR-1 locus defect with class II promoter occupancy alterations and distinguish these alterations from the ones observed in phenotypically similar but genetically distinct MHC class II-negative cells --- > Thus, the use of DNase I allowed us, for the first time, to correlate the AIR-1 locus defect with class II promoter occupancy alterations and distinguish these alterations from the ones observed in phenotypically similar but genetically distinct MHC class II-negative cells 3011c3349,3351 < Regulation of <cons sem="G#other_name">cell-type-specific <cons sem="G#protein_subunit">interleukin-2 receptor alpha-chain</cons> gene expression</cons>: potential role of physical interactions between <cons sem="G#protein_molecule">Elf-1</cons>, <cons sem="G#protein_molecule">HMG-I(Y)</cons>, and <cons sem="G#protein_family_or_group">NF-kappa B family proteins</cons>. --- > > <sentence>Regulation of <cons sem="G#other_name">cell-type-specific <cons sem="G#protein_subunit">interleukin-2 receptor alpha-chain</cons> gene expression</cons>: potential role of physical interactions between <cons sem="G#protein_molecule">Elf-1</cons>, <cons sem="G#protein_molecule">HMG-I(Y)</cons>, and <cons sem="G#protein_family_or_group">NF-kappa B family proteins</cons>.</sentence> > 3029c3369,3371 < Isolation of <cons sem="G#DNA_family_or_group">cDNA clones</cons> for 42 different <cons sem="G#protein_family_or_group">Kruppel-related zinc finger proteins</cons> expressed in the <cons sem="G#cell_line">human monoblast cell line U-937</cons>. --- > > <sentence>Isolation of <cons sem="G#DNA_family_or_group">cDNA clones</cons> for 42 different <cons sem="G#protein_family_or_group">Kruppel-related zinc finger proteins</cons> expressed in the <cons sem="G#cell_line">human monoblast cell line U-937</cons>.</sentence> > 3045c3387,3389 < <cons sem="G#DNA_N/A">CAG repeat length variation</cons> in <cons sem="G#cell_type">sperm</cons> from a <cons sem="G#multi_cell">patient</cons> with <cons sem="G#other_name">Kennedy's disease</cons>. --- > > <sentence><cons sem="G#DNA_N/A">CAG repeat length variation</cons> in <cons sem="G#cell_type">sperm</cons> from a <cons sem="G#multi_cell">patient</cons> with <cons sem="G#other_name">Kennedy's disease</cons>.</sentence> > 3062c3406,3408 < <cons sem="G#other_organic_compound">Aspirin-like drugs</cons> can protect <cons sem="G#cell_type">human T lymphocytes</cons> against <cons sem="G#other_name">benzoquinone cytotoxicity</cons>: evidence for a <cons sem="G#other_name">NAD(P)H:quinone reductase-dependent mechanism</cons>. --- > > <sentence><cons sem="G#other_organic_compound">Aspirin-like drugs</cons> can protect <cons sem="G#cell_type">human T lymphocytes</cons> against <cons sem="G#other_name">benzoquinone cytotoxicity</cons>: evidence for a <cons sem="G#other_name"><cons sem="G#protein_molecule">NAD(P)H:quinone reductase</cons>-dependent mechanism</cons>.</sentence> > 3072c3418 < ALDs induced QR activity in the M4 cells in the same range of concentrations that protected the cells against BQ toxicity. --- > ALDs induced QR activity in the M4 cells in the same range of concentrations that protected the cells against BQ toxicity. 3082c3428,3430 < Correlation of <cons sem="G#other_name">differentiation-inducing activity</cons> of <cons sem="G#other_organic_compound">retinoids</cons> on <cons sem="G#cell_line">human leukemia cell lines</cons> <cons sem="G#cell_line">HL-60</cons> and <cons sem="G#cell_line">NB4</cons>. --- > > <sentence>Correlation of <cons sem="G#other_name">differentiation-inducing activity</cons> of <cons sem="G#other_organic_compound">retinoids</cons> on <cons sem="G#cell_line">human leukemia cell lines</cons> <cons sem="G#cell_line">HL-60</cons> and <cons sem="G#cell_line">NB4</cons>.</sentence> > 3093c3441,3443 < <cons sem="G#protein_family_or_group">Platelet-activating factor</cons> (<cons sem="G#protein_family_or_group">PAF</cons>) positively auto-regulates the expression of <cons sem="G#protein_molecule">human PAF receptor transcript 1</cons> (<cons sem="G#other_name">leukocyte-type</cons>) through <cons sem="G#protein_molecule">NF-kappa B</cons>. --- > > <sentence><cons sem="G#protein_family_or_group">Platelet-activating factor</cons> (<cons sem="G#protein_family_or_group">PAF</cons>) positively auto-regulates the expression of <cons sem="G#protein_molecule">human PAF receptor transcript 1</cons> (<cons sem="G#other_name">leukocyte-type</cons>) through <cons sem="G#protein_molecule">NF-kappa B</cons>.</sentence> > 3106c3456,3458 < One gene, two <cons sem="G#RNA_family_or_group">transcripts</cons>: isolation of an <cons sem="G#other_name">alternative transcript encoding</cons> for the <cons sem="G#protein_molecule">autoantigen La/SS-B</cons> from a <cons sem="G#DNA_family_or_group">cDNA library</cons> of a <cons sem="G#multi_cell">patient</cons> with <cons sem="G#other_name">primary Sjogrens' syndrome</cons>. --- > > <sentence>One gene, two <cons sem="G#RNA_family_or_group">transcripts</cons>: isolation of an <cons sem="G#other_name">alternative transcript encoding</cons> for the <cons sem="G#protein_molecule">autoantigen La/SS-B</cons> from a <cons sem="G#DNA_family_or_group">cDNA library</cons> of a <cons sem="G#multi_cell">patient</cons> with <cons sem="G#other_name">primary Sjogrens' syndrome</cons>.</sentence> > 3122c3474,3476 < Cross-linking <cons sem="G#protein_molecule">CD40</cons> on <cons sem="G#cell_type">B cells</cons> rapidly activates <cons sem="G#protein_molecule">nuclear factor-kappa B</cons>. --- > > <sentence>Cross-linking <cons sem="G#protein_molecule">CD40</cons> on <cons sem="G#cell_type">B cells</cons> rapidly activates <cons sem="G#protein_molecule">nuclear factor-kappa B</cons>.</sentence> > 3126c3480 < Tyrosine kinase activity is increased shortly after engagement of this receptor. --- > Tyrosine kinase activity is increased shortly after engagement of this receptor. 3128c3482 < In this study, we demonstrate that nuclear factor (NF)-kappa B and NF- kappa B-like transcription factors are activated after cross-linking CD40 on resting human tonsillar B cells and on B cell lines. --- > In this study, we demonstrate that nuclear factor (NF)-kappa B and NF- kappa B-like transcription factors are activated after cross-linking CD40 on resting human tonsillar B cells and on B cell lines. 3140c3494,3496 < <cons sem="G#other_organic_compound">Protease inhibitors</cons> block <cons sem="G#other_name"><cons sem="G#lipid">lipopolysaccharide</cons> induction</cons> of tissue factor <cons sem="G#other_name">gene expression</cons> in <cons sem="G#cell_type">human monocytic cells</cons> by preventing activation of <cons sem="G#protein_family_or_group">c- Rel/<cons sem="G#protein_subunit">p65</cons> heterodimers.</cons> --- > > <sentence><cons sem="G#other_organic_compound">Protease inhibitors</cons> block <cons sem="G#other_name"><cons sem="G#lipid">lipopolysaccharide</cons> induction</cons> of tissue factor <cons sem="G#other_name">gene expression</cons> in <cons sem="G#cell_type">human monocytic cells</cons> by preventing activation of <cons sem="G#protein_family_or_group">c- Rel/<cons sem="G#protein_subunit">p65</cons> heterodimers.</cons></sentence> > 3158c3514,3516 < <cons sem="G#protein_family_or_group"><cons sem="G#lipid">1,25-Dihydroxyvitamin D3</cons> receptors</cons> in <cons sem="G#cell_type">peripheral blood mononuclear cells</cons> from <cons sem="G#multi_cell">patients</cons> with <cons sem="(AND G#other_name G#other_name)"><cons>primary</cons> and <cons>secondary</cons> <cons>hyperparathyroidism</cons></cons>. --- > > <sentence><cons sem="G#protein_family_or_group"><cons sem="G#lipid">1,25-Dihydroxyvitamin D3</cons> receptors</cons> in <cons sem="G#cell_type">peripheral blood mononuclear cells</cons> from <cons sem="G#multi_cell">patients</cons> with <cons sem="(AND G#other_name G#other_name)"><cons>primary</cons> and <cons>secondary</cons> <cons>hyperparathyroidism</cons></cons>.</sentence> > 3173c3531,3533 < The severe phenotype of <cons sem="G#multi_cell">females</cons> with <cons sem="G#DNA_molecule">tiny ring <cons sem="G#DNA_molecule">X chromosomes</cons></cons> is associated with inability of these <cons sem="G#DNA_family_or_group">chromosomes</cons> to undergo <cons sem="G#other_name">X inactivation</cons>. --- > > <sentence>The severe phenotype of <cons sem="G#multi_cell">females</cons> with <cons sem="G#DNA_molecule">tiny ring <cons sem="G#DNA_molecule">X chromosomes</cons></cons> is associated with inability of these <cons sem="G#DNA_family_or_group">chromosomes</cons> to undergo <cons sem="G#other_name">X inactivation</cons>.</sentence> > 3191c3551,3553 < Inhibition of activation of <cons sem="G#protein_molecule">transcription factor <cons sem="G#protein_molecule">AP-1</cons></cons> by <cons sem="G#protein_molecule">CD28</cons> signalling in <cons sem="G#cell_type">human T-cells</cons>. --- > > <sentence>Inhibition of activation of <cons sem="G#protein_molecule">transcription factor <cons sem="G#protein_molecule">AP-1</cons></cons> by <cons sem="G#protein_molecule">CD28</cons> signalling in <cons sem="G#cell_type">human T-cells</cons>.</sentence> > 3194c3556 < The increase in IL-2 gene expression triggered by CD28 involves a kappa B-like sequence in the 5'-regulatory region of the IL-2 promoter, called CD28-responsive element. --- > The increase in IL-2 gene expression triggered by CD28 involves a kappa B-like sequence in the 5'-regulatory region of the IL-2 promoter, called CD28-responsive element. 3207c3569,3571 < <cons sem="G#protein_molecule"><cons sem="G#virus">HIV-1</cons> Nef</cons> leads to inhibition or activation of <cons sem="G#cell_type">T cells</cons> depending on its <cons sem="G#other_name">intracellular localization</cons>. --- > > <sentence><cons sem="G#protein_molecule"><cons sem="G#virus">HIV-1</cons> Nef</cons> leads to inhibition or activation of <cons sem="G#cell_type">T cells</cons> depending on its <cons sem="G#other_name">intracellular localization</cons>.</sentence> > 3213,3214c3577,3578 < Expressed in the cytoplasm or on the cell surface, the chimera inhibited or activated early signaling events from the T cell antigen receptor. < Activated Jurkat cells died by apoptosis, and only cells with mutated nef genes expressing truncated Nefs survived, which rendered Nef nonfunctional. --- > Expressed in the cytoplasm or on the cell surface, the chimera inhibited or activated early signaling events from the T cell antigen receptor. > Activated Jurkat cells died by apoptosis, and only cells with mutated nef genes expressing truncated Nefs survived, which rendered Nef nonfunctional. 3224c3588,3590 < An intricate arrangement of binding sites for the <cons sem="G#protein_family_or_group">Ets family</cons> of <cons sem="G#protein_family_or_group">transcription factors</cons> regulates activity of the <cons sem="G#DNA_domain_or_region">alpha 4 integrin gene promoter</cons>. --- > > <sentence>An intricate arrangement of binding sites for the <cons sem="G#protein_family_or_group">Ets family</cons> of <cons sem="G#protein_family_or_group">transcription factors</cons> regulates activity of the <cons sem="G#DNA_domain_or_region">alpha 4 integrin gene promoter</cons>.</sentence> > 3237c3603 < We conclude that although neither of the two 5'-most Ets sites alone binds nuclear protein, they appear to act as modulators which control the pattern of Ets proteins that bind the alpha 4 gene promoter. --- > We conclude that although neither of the two 5'-most Ets sites alone binds nuclear protein, they appear to act as modulators which control the pattern of Ets proteins that bind the alpha 4 gene promoter. 3246c3612,3614 < Mechanism of <cons sem="G#other_name"><cons sem="G#lipid">antiandrogen</cons> action</cons>: conformational changes of the receptor. --- > > <sentence>Mechanism of <cons sem="G#other_name"><cons sem="G#lipid">antiandrogen</cons> action</cons>: conformational changes of the receptor.</sentence> > 3248,3249c3616,3617 < Androgen receptor mRNA was translated in vitro, and androgen- and antiandrogen-bound receptor complexes were studied using limited proteolytic digestion by trypsin. < Partial proteolysis of androgen-bound receptor protein resulted in a 29-kDa proteolysis-resisting fragment, whereas antiandrogen binding stabilised a 35-kDa fragment. --- > Androgen receptor mRNA was translated in vitro, and androgen- and antiandrogen-bound receptor complexes were studied using limited proteolytic digestion by trypsin. > Partial proteolysis of androgen-bound receptor protein resulted in a 29-kDa proteolysis-resisting fragment, whereas antiandrogen binding stabilised a 35-kDa fragment. 3251,3254c3619,3622 < Several antiandrogens show agonistic properties for a mutated androgen receptor (LNCaP cell variant); trypsin digestion of antiandrogen-bound mutated receptor also resulted in a 29-kDa fragment. < Our results point to an important difference between antiandrogens and antagonists of other steroid hormone receptors. < Antiandrogens result in protection of both the hinge region and C-terminus of the androgen receptor agonist proteolytic attack, whereas other studies showed that antiestrogens and antiprogestagens expose the C-terminal end of the ligand binding domain of their respective receptors to protease. < Differences in conformation of the hinge region distinguish androgen-bound from antiandrogen-bound receptor complexes, which represents an important feature of antiandrogen action. --- > Several antiandrogens show agonistic properties for a mutated androgen receptor (LNCaP cell variant); trypsin digestion of antiandrogen-bound mutated receptor also resulted in a 29-kDa fragment. > Our results point to an important difference between antiandrogens and antagonists of other steroid hormone receptors. > Antiandrogens result in protection of both the hinge region and C-terminus of the androgen receptor agonist proteolytic attack, whereas other studies showed that antiestrogens and antiprogestagens expose the C-terminal end of the ligand binding domain of their respective receptors to protease. > Differences in conformation of the hinge region distinguish androgen-bound from antiandrogen-bound receptor complexes, which represents an important feature of antiandrogen action. 3262c3630,3632 < Activation of <cons sem="G#protein_molecule">nuclear factor kappa B</cons> in <cons sem="G#cell_line">human <cons sem="G#cell_line">neuroblastoma cell lines</cons></cons>. --- > > <sentence>Activation of <cons sem="G#protein_molecule">nuclear factor kappa B</cons> in <cons sem="G#cell_line">human <cons sem="G#cell_line">neuroblastoma cell lines</cons></cons>.</sentence> > 3283c3653,3655 < <cons sem="G#protein_molecule">ERP</cons>, a new member of the <cons sem="G#protein_family_or_group">ets transcription factor/oncoprotein family</cons>: <cons sem="G#other_name">cloning</cons>, <cons sem="G#other_name">characterization</cons>, and <cons sem="G#other_name">differential expression</cons> during <cons sem="G#other_name">B- lymphocyte development</cons>. --- > > <sentence><cons sem="G#protein_molecule">ERP</cons>, a new member of the <cons sem="G#protein_family_or_group">ets transcription factor/oncoprotein family</cons>: <cons sem="G#other_name">cloning</cons>, <cons sem="G#other_name">characterization</cons>, and <cons sem="G#other_name">differential expression</cons> during <cons sem="G#other_name">B- lymphocyte development</cons>.</sentence> > 3290c3662 < Three additional smaller regions show homology to the ELK-1 and SAP-1 genes, a subgroup of the ets gene family that interacts with the serum response factor. --- > Three additional smaller regions show homology to the ELK-1 and SAP-1 genes, a subgroup of the ets gene family that interacts with the serum response factor. 3303c3675,3677 < Gene for a <cons sem="G#protein_family_or_group">tissue-specific transcriptional activator</cons> (<cons sem="G#protein_family_or_group">EBF</cons> or <cons sem="G#protein_family_or_group">Olf-1</cons>), expressed in <cons sem="G#cell_type">early B lymphocytes</cons>, <cons sem="G#cell_type">adipocytes</cons>, and <cons sem="G#cell_type">olfactory neurons</cons>, is located on <cons sem="G#DNA_molecule">human chromosome 5</cons>, <cons sem="G#DNA_domain_or_region">band q34</cons>, and <cons sem="G#DNA_molecule">proximal mouse chromosome 11</cons>. --- > > <sentence>Gene for a <cons sem="G#protein_family_or_group">tissue-specific transcriptional activator</cons> (<cons sem="G#protein_family_or_group">EBF</cons> or <cons sem="G#protein_family_or_group">Olf-1</cons>), expressed in <cons sem="G#cell_type">early B lymphocytes</cons>, <cons sem="G#cell_type">adipocytes</cons>, and <cons sem="G#cell_type">olfactory neurons</cons>, is located on <cons sem="G#DNA_molecule">human chromosome 5</cons>, <cons sem="G#DNA_domain_or_region">band q34</cons>, and <cons sem="G#DNA_molecule">proximal mouse chromosome 11</cons>.</sentence> > 3316c3690,3692 < <cons sem="G#protein_molecule">Calcineurin</cons> activates transcription from the <cons sem="G#DNA_domain_or_region">GM-CSF promoter</cons> in synergy with either <cons sem="G#protein_molecule">protein kinase C</cons> or <cons sem="G#protein_molecule">NF-kappa B</cons>/<cons sem="G#protein_molecule">AP-1</cons> in <cons sem="G#cell_type">T cells</cons>. --- > > <sentence><cons sem="G#protein_molecule">Calcineurin</cons> activates transcription from the <cons sem="G#DNA_domain_or_region">GM-CSF promoter</cons> in synergy with either <cons sem="G#protein_molecule">protein kinase C</cons> or <cons sem="G#protein_molecule">NF-kappa B</cons>/<cons sem="G#protein_molecule">AP-1</cons> in <cons sem="G#cell_type">T cells</cons>.</sentence> > 3334c3710,3712 < <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">Nonpituitary human prolactin gene</cons> transcription</cons> is independent of <cons sem="G#protein_molecule">Pit-1</cons> and differentially controlled in <cons sem="G#cell_type">lymphocytes</cons> and in <cons sem="G#tissue">endometrial stroma</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">Nonpituitary human prolactin gene</cons> transcription</cons> is independent of <cons sem="G#protein_molecule">Pit-1</cons> and differentially controlled in <cons sem="G#cell_type">lymphocytes</cons> and in <cons sem="G#tissue">endometrial stroma</cons>.</sentence> > 3339c3717 < We focused our studies on the role of Pit-1 and of PR as potential transcriptional regulators, since the POU domain protein Pit-1 is essential in the control of pituitary PRL expression, and progesterone induces decidual transformation of the endometrial stroma, a differentiation process during which the decidual PRL gene is activated. --- > We focused our studies on the role of Pit-1 and of PR as potential transcriptional regulators, since the POU domain protein Pit-1 is essential in the control of pituitary PRL expression, and progesterone induces decidual transformation of the endometrial stroma, a differentiation process during which the decidual PRL gene is activated. 3342c3720 < When we compared the activity of the transfected dPRL promoter in PRL-secreting and nonsecreting lymphoid cells, we found that the 3 kb 5'-flanking region of the dPRL promoter did not contain elements restricting expression to only those lymphocytes that produce PRL but allowed expression of fusion reporter genes irrespective of the status of the endogenous PRL gene. --- > When we compared the activity of the transfected dPRL promoter in PRL-secreting and nonsecreting lymphoid cells, we found that the 3 kb 5'-flanking region of the dPRL promoter did not contain elements restricting expression to only those lymphocytes that produce PRL but allowed expression of fusion reporter genes irrespective of the status of the endogenous PRL gene. 3344c3722 < Activation of the dPRL promoter construct in these undifferentiated cells could however be induced by the addition of cAMP, in the absence of progesterone, suggesting that a signal transduced through the cAMP signaling pathway is a primary inducer of decidual PRL gene expression --- > Activation of the dPRL promoter construct in these undifferentiated cells could however be induced by the addition of cAMP, in the absence of progesterone, suggesting that a signal transduced through the cAMP signaling pathway is a primary inducer of decidual PRL gene expression 3352c3730,3732 < Signals and <cons sem="G#protein_family_or_group">nuclear factors</cons> that regulate the expression of <cons sem="(AND G#DNA_domain_or_region G#DNA_domain_or_region)"><cons>interleukin- 4</cons> and <cons>interleukin-5</cons> <cons>genes</cons></cons> in <cons sem="G#cell_type">helper T cells</cons>. --- > > <sentence>Signals and <cons sem="G#protein_family_or_group">nuclear factors</cons> that regulate the expression of <cons sem="(AND G#DNA_domain_or_region G#DNA_domain_or_region)"><cons>interleukin- 4</cons> and <cons>interleukin-5</cons> <cons>genes</cons></cons> in <cons sem="G#cell_type">helper T cells</cons>.</sentence> > 3373c3753,3755 < Solution structure of a <cons sem="G#protein_domain_or_region">POU-specific homeodomain</cons>: <cons sem="G#other_name">3D-NMR studies</cons> of human <cons sem="G#protein_family_or_group">B-cell transcription factor</cons> <cons sem="G#protein_molecule">Oct-2</cons>. --- > > <sentence>Solution structure of a <cons sem="G#protein_domain_or_region">POU-specific homeodomain</cons>: <cons sem="G#other_name">3D-NMR studies</cons> of human <cons sem="G#protein_family_or_group">B-cell transcription factor</cons> <cons sem="G#protein_molecule">Oct-2</cons>.</sentence> > 3391c3773,3775 < <cons sem="(AND G#other_name G#other_name)"><cons>NF-kappa B</cons><cons>-dependent</cons> and <cons>-independent</cons> <cons>pathways</cons></cons> of <cons sem="G#other_name">HIV activation</cons> in a <cons sem="G#cell_line">chronically infected T cell line</cons>. --- > > <sentence><cons sem="(AND G#other_name G#other_name)"><cons>NF-kappa B</cons><cons>-dependent</cons> and <cons>-independent</cons> <cons>pathways</cons></cons> of <cons sem="G#other_name">HIV activation</cons> in a <cons sem="G#cell_line">chronically infected T cell line</cons>.</sentence> > 3405c3789,3791 < <cons sem="G#protein_family_or_group">JNK</cons> is involved in <cons sem="G#other_name">signal integration</cons> during <cons sem="G#other_name">costimulation</cons> of <cons sem="G#cell_type">T lymphocytes</cons>. --- > > <sentence><cons sem="G#protein_family_or_group">JNK</cons> is involved in <cons sem="G#other_name">signal integration</cons> during <cons sem="G#other_name">costimulation</cons> of <cons sem="G#cell_type">T lymphocytes</cons>.</sentence> > 3411c3797 < Similar to its effect on IL-2 induction, cyclosporin A (CsA) inhibited the synergistic activation of JNK, and a competitive inhibitor of Jun phosphorylation by JNK inhibited IL-2 promoter activation. --- > Similar to its effect on IL-2 induction, cyclosporin A (CsA) inhibited the synergistic activation of JNK, and a competitive inhibitor of Jun phosphorylation by JNK inhibited IL-2 promoter activation. 3421c3807,3809 < Inhibition of <cons sem="G#other_name"><cons sem="G#cell_type">rat splenocyte</cons> proliferation</cons> with <cons sem="G#lipid">methylprednisolone</cons>: in vivo effect of <cons sem="G#other_name">liposomal formulation</cons>. --- > > <sentence>Inhibition of <cons sem="G#other_name"><cons sem="G#cell_type">rat splenocyte</cons> proliferation</cons> with <cons sem="G#lipid">methylprednisolone</cons>: in vivo effect of <cons sem="G#other_name">liposomal formulation</cons>.</sentence> > 3441c3829,3831 < Function of <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">NF-kappa B</cons>/Rel binding sites</cons> in the <cons sem="G#DNA_domain_or_region">major histocompatibility complex class II invariant chain promoter</cons> is dependent on cell-specific binding of different <cons sem="G#protein_subunit"><cons sem="G#protein_molecule">NF-kappa B</cons>/Rel subunits</cons>. --- > > <sentence>Function of <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">NF-kappa B</cons>/Rel binding sites</cons> in the <cons sem="G#DNA_domain_or_region">major histocompatibility complex class II invariant chain promoter</cons> is dependent on cell-specific binding of different <cons sem="G#protein_subunit"><cons sem="G#protein_molecule">NF-kappa B</cons>/Rel subunits</cons>.</sentence> > 3459c3849,3851 < <cons sem="G#other_name"><cons sem="G#virus">Epstein-Barr virus</cons> (<cons sem="G#virus">EBV</cons>) replicative gene expression</cons> in <cons sem="G#cell_type">tumour cells</cons> of <cons sem="G#other_name">AIDS-related non-Hodgkin's lymphoma</cons> in relation to <cons sem="G#other_name">CD4 cell number</cons> and <cons sem="G#other_name">antibody titres</cons> to <cons sem="G#virus">EBV</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#virus">Epstein-Barr virus</cons> (<cons sem="G#virus">EBV</cons>) replicative gene expression</cons> in <cons sem="G#cell_type">tumour cells</cons> of <cons sem="G#other_name">AIDS-related non-Hodgkin's lymphoma</cons> in relation to <cons sem="G#other_name"><cons sem="G#protein_molecule">CD4</cons> cell number</cons> and <cons sem="G#other_name">antibody titres</cons> to <cons sem="G#virus">EBV</cons>.</sentence> > 3461,3462c3853,3854 < OBJECTIVE: To determine whether activation of Epstein-Barr virus (EBV) replication in tumour cells of AIDS-related non-Hodgkin's lymphoma (ARNHL) is correlated with CD4+ cell counts and influences antibody response to EBV [anti-Z Epstein-Barr replicative activator (ZEBRA), anti-early antigen (EA), anti-viral capsid antigen (VCA)]. < DESIGN: Retrospective study based on immunohistochemistry and in situ hybridization to detect EBV replicative gene products in tissue samples from patients affected by ARNHL and correlation with CD4+ cell counts and results of EBV serology (including anti-ZEBRA activity) in sera from the same patients. --- > OBJECTIVE: To determine whether activation of Epstein-Barr virus (EBV) replication in tumour cells of AIDS-related non-Hodgkin's lymphoma (ARNHL) is correlated with CD4+ cell counts and influences antibody response to EBV [anti-Z Epstein-Barr replicative activator (ZEBRA), anti-early antigen (EA), anti-viral capsid antigen (VCA)]. > DESIGN: Retrospective study based on immunohistochemistry and in situ hybridization to detect EBV replicative gene products in tissue samples from patients affected by ARNHL and correlation with CD4+ cell counts and results of EBV serology (including anti-ZEBRA activity) in sera from the same patients. 3465c3857 < Results were statistically correlated with those of CD4+ cell counts (17 out of 17) and with anti- EBV antibody titres (13 out of 17) assessed using standard immunofluorescence method and enzyme-linked immunosorbent assay procedure using recombinant ZEBRA protein and synthetic peptides as antigens. --- > Results were statistically correlated with those of CD4+ cell counts (17 out of 17) and with anti- EBV antibody titres (13 out of 17) assessed using standard immunofluorescence method and enzyme-linked immunosorbent assay procedure using recombinant ZEBRA protein and synthetic peptides as antigens. 3467c3859 < Demonstration of replicative gene expression did not correlate with either low CD4+ cell counts (P > 0.05) or anti-EBV antibody titres (P > 0.05). --- > Demonstration of replicative gene expression did not correlate with either low CD4+ cell counts (P > 0.05) or anti-EBV antibody titres (P > 0.05). 3478c3870,3872 < Effects of <cons sem="G#protein_molecule">prostaglandin E2</cons> on <cons sem="G#cell_line">Th0-type human T cell clones</cons>: modulation of functions of <cons sem="G#protein_family_or_group">nuclear proteins</cons> involved in <cons sem="G#other_name">cytokine production</cons>. --- > > <sentence>Effects of <cons sem="G#protein_molecule">prostaglandin E2</cons> on <cons sem="G#cell_line">Th0-type human T cell clones</cons>: modulation of functions of <cons sem="G#protein_family_or_group">nuclear proteins</cons> involved in <cons sem="G#other_name"><cons sem="G#protein_family_or_group">cytokine</cons> production</cons>.</sentence> > 3480c3874 < The effects of prostaglandin E2 (PGE2) on cytokine production and proliferation of the CD4+ human helper T cell clone SP-B21 were investigated. --- > The effects of prostaglandin E2 (PGE2) on cytokine production and proliferation of the CD4+ human helper T cell clone SP-B21 were investigated. 3482c3876 < Addition of rIL-2 fully restored the proliferative response and partially restored the production of IL-4 and IL-5, but not that of other cytokines. --- > Addition of rIL-2 fully restored the proliferative response and partially restored the production of IL-4 and IL-5, but not that of other cytokines. 3499c3893,3895 < Characterization of <cons sem="G#protein_molecule">NF(P)</cons>, the <cons sem="G#protein_family_or_group">nuclear factor</cons> that interacts with the regulatory <cons sem="G#DNA_domain_or_region">P sequence</cons> (<cons sem="G#polynucleotide">5'-CGAAAATTTCC-3'</cons>) of the <cons sem="G#DNA_domain_or_region">human interleukin-4 gene</cons>: relationship to <cons sem="G#protein_molecule">NF-kappa B</cons> and <cons sem="G#protein_molecule">NF-AT</cons>. --- > > <sentence>Characterization of <cons sem="G#protein_molecule">NF(P)</cons>, the <cons sem="G#protein_family_or_group">nuclear factor</cons> that interacts with the regulatory <cons sem="G#DNA_domain_or_region">P sequence</cons> (<cons sem="G#polynucleotide">5'-CGAAAATTTCC-3'</cons>) of the <cons sem="G#DNA_domain_or_region">human interleukin-4 gene</cons>: relationship to <cons sem="G#protein_molecule">NF-kappa B</cons> and <cons sem="G#protein_molecule">NF-AT</cons>.</sentence> > 3503,3504c3899,3900 < NF-kappa B (P65 or P65/P50 heterodimer) bound to the P sequence in electrophoretic mobility shift assays (EMSA) and activated transcription through the P sequence when expression plasmids were cotransfected with P sequence-driven reporter plasmids in Jurkat T cells. < In EMSAs, NF(P) binding was inhibited by the unlabeled NF-AT binding site but not by the unlabeled AP1 binding site and purified NF- AT contained an activity that bound to the P sequence. --- > NF-kappa B (P65 or P65/P50 heterodimer) bound to the P sequence in electrophoretic mobility shift assays (EMSA) and activated transcription through the P sequence when expression plasmids were cotransfected with P sequence-driven reporter plasmids in Jurkat T cells. > In EMSAs, NF(P) binding was inhibited by the unlabeled NF-AT binding site but not by the unlabeled AP1 binding site and purified NF- AT contained an activity that bound to the P sequence. 3515c3911,3913 < Activation of <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">early growth response 1 gene</cons> transcription</cons> and <cons sem="G#protein_molecule">pp90rsk</cons> during induction of <cons sem="G#other_name">monocytic differentiation</cons>. --- > > <sentence>Activation of <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">early growth response 1 gene</cons> transcription</cons> and <cons sem="G#protein_molecule">pp90rsk</cons> during induction of <cons sem="G#other_name">monocytic differentiation</cons>.</sentence> > 3535c3933,3935 < <cons sem="G#other_organic_compound">Antioxidants</cons> inhibit <cons sem="G#other_name"><cons sem="G#cell_type">monocyte</cons> adhesion</cons> by suppressing <cons sem="G#other_name"><cons sem="G#protein_molecule">nuclear factor- kappa B</cons> mobilization</cons> and induction of <cons sem="G#protein_molecule">vascular cell adhesion molecule-1</cons> in <cons sem="G#cell_type">endothelial cells</cons> stimulated to generate <cons sem="G#inorganic">radicals</cons>. --- > > <sentence><cons sem="G#other_organic_compound">Antioxidants</cons> inhibit <cons sem="G#other_name"><cons sem="G#cell_type">monocyte</cons> adhesion</cons> by suppressing <cons sem="G#other_name"><cons sem="G#protein_molecule">nuclear factor- kappa B</cons> mobilization</cons> and induction of <cons sem="G#protein_molecule">vascular cell adhesion molecule-1</cons> in <cons sem="G#cell_type">endothelial cells</cons> stimulated to generate <cons sem="G#inorganic">radicals</cons>.</sentence> > 3554c3954,3956 < Displacement of an <cons sem="G#protein_family_or_group">E-box-binding repressor</cons> by <cons sem="G#protein_family_or_group">basic helix-loop-helix proteins</cons>: implications for <cons sem="G#other_name">B-cell specificity</cons> of the <cons sem="G#DNA_domain_or_region">immunoglobulin heavy-chain enhancer</cons>. --- > > <sentence>Displacement of an <cons sem="G#protein_family_or_group">E-box-binding repressor</cons> by <cons sem="G#protein_family_or_group">basic helix-loop-helix proteins</cons>: implications for <cons sem="G#other_name">B-cell specificity</cons> of the <cons sem="G#DNA_domain_or_region">immunoglobulin heavy-chain enhancer</cons>.</sentence> > 3568c3970,3972 < Inhibition of <cons sem="G#protein_molecule">NF-kappa B</cons> by <cons sem="G#other_organic_compound">sodium salicylate</cons> and <cons sem="G#other_organic_compound">aspirin</cons> [see comments] --- > > <sentence>Inhibition of <cons sem="G#protein_molecule">NF-kappa B</cons> by <cons sem="G#other_organic_compound">sodium salicylate</cons> and <cons sem="G#other_organic_compound">aspirin</cons> [see comments]</sentence> > 3581c3985,3987 < Effects of the <cons sem="G#other_name">antisense myb expression</cons> on <cons sem="(AND G#other_name G#other_name)"><cons>hemin-</cons> and <cons>erythropoietin-</cons> <cons>induced erythroid differentiation</cons></cons> of <cons sem="G#cell_line">K562 cells</cons>. --- > > <sentence>Effects of the <cons sem="G#other_name">antisense myb expression</cons> on <cons sem="(AND G#other_name G#other_name)"><cons>hemin-</cons> and <cons>erythropoietin-</cons> <cons>induced erythroid differentiation</cons></cons> of <cons sem="G#cell_line">K562 cells</cons>.</sentence> > 3598c4004,4006 < <cons sem="G#other_name">Prenatal immune challenge</cons> alters the <cons sem="G#body_part">hypothalamic-pituitary- adrenocortical axis</cons> in <cons sem="G#multi_cell">adult rats</cons>. --- > > <sentence><cons sem="G#other_name">Prenatal immune challenge</cons> alters the <cons sem="G#body_part">hypothalamic-pituitary- adrenocortical axis</cons> in <cons sem="G#multi_cell">adult rats</cons>.</sentence> > 3615c4023,4025 < A low <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">NM23.H1 gene</cons> expression</cons> identifying <cons sem="G#other_name">high malignancy human melanomas</cons>. --- > > <sentence>A low <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">NM23.H1 gene</cons> expression</cons> identifying <cons sem="G#other_name">high malignancy human melanomas</cons>.</sentence> > 3630c4040,4042 < Activation of a novel <cons sem="G#protein_family_or_group"><cons sem="G#amino_acid_monomer">serine</cons>/<cons sem="G#amino_acid_monomer">threonine</cons> kinase</cons> that phosphorylates <cons sem="G#protein_molecule">c-Fos</cons> upon stimulation of <cons sem="(AND G#cell_type G#cell_type)"><cons>T</cons> and <cons>B</cons> <cons>lymphocytes</cons></cons> via antigen and <cons sem="G#protein_family_or_group">cytokine receptors</cons>. --- > > <sentence>Activation of a novel <cons sem="G#protein_family_or_group"><cons sem="G#amino_acid_monomer">serine</cons>/<cons sem="G#amino_acid_monomer">threonine</cons> kinase</cons> that phosphorylates <cons sem="G#protein_molecule">c-Fos</cons> upon stimulation of <cons sem="(AND G#cell_type G#cell_type)"><cons>T</cons> and <cons>B</cons> <cons>lymphocytes</cons></cons> via antigen and <cons sem="G#protein_family_or_group">cytokine receptors</cons>.</sentence> > 3649c4061,4063 < <cons sem="G#other_name">Antigenic specificities</cons> of <cons sem="G#cell_line">human CD4+ T-cell clones</cons> recovered from <cons sem="G#tissue">recurrent genital <cons sem="G#virus">herpes simplex virus type 2</cons> lesions</cons>. --- > > <sentence><cons sem="G#other_name">Antigenic specificities</cons> of <cons sem="G#cell_line">human CD4+ T-cell clones</cons> recovered from <cons sem="G#tissue">recurrent genital <cons sem="G#virus">herpes simplex virus type 2</cons> lesions</cons>.</sentence> > 3667c4081,4083 < <cons sem="G#other_name">Marked basophilia</cons> in <cons sem="G#other_name">acute promyelocytic leukaemia</cons> treated with <cons sem="G#other_organic_compound">all- trans retinoic acid</cons>: molecular analysis of the cell origin of the <cons sem="G#cell_type">basophils</cons>. --- > > <sentence><cons sem="G#other_name">Marked basophilia</cons> in <cons sem="G#other_name">acute promyelocytic leukaemia</cons> treated with <cons sem="G#other_organic_compound">all- trans retinoic acid</cons>: molecular analysis of the cell origin of the <cons sem="G#cell_type">basophils</cons>.</sentence> > 3680c4096,4098 < Activation of the <cons sem="G#DNA_domain_or_region">interleukin 6 gene</cons> by <cons sem="G#mono_cell">Mycobacterium tuberculosis</cons> or <cons sem="G#lipid">lipopolysaccharide</cons> is mediated by <cons sem="G#protein_molecule">nuclear factors NF-IL6</cons> and <cons sem="G#protein_molecule">NF-kappa B</cons> [published erratum appears in Proc Natl Acad Sci U S A 1995 Apr 11;92(8):3632] --- > > <sentence>Activation of the <cons sem="G#DNA_domain_or_region">interleukin 6 gene</cons> by <cons sem="G#mono_cell">Mycobacterium tuberculosis</cons> or <cons sem="G#lipid">lipopolysaccharide</cons> is mediated by <cons sem="G#protein_molecule">nuclear factors NF-IL6</cons> and <cons sem="G#protein_molecule">NF-kappa B</cons> [published erratum appears in Proc Natl Acad Sci U S A 1995 Apr 11;92(8):3632]</sentence> > 3687c4105 < Both LAM- and LPS- inducible IL-6 promoter activity was localized to a DNA fragment, positions -158 to -49, by deletion analysis and chloramphenicol acetyltransferase assay. --- > Both LAM- and LPS- inducible IL-6 promoter activity was localized to a DNA fragment, positions -158 to -49, by deletion analysis and chloramphenicol acetyltransferase assay. 3699c4117,4119 < Regulation of <cons sem="G#other_name">CD14 expression</cons> during <cons sem="G#other_name">monocytic differentiation</cons> induced with <cons sem="G#lipid">1 alpha,25-dihydroxyvitamin D3</cons>. --- > > <sentence>Regulation of <cons sem="G#other_name"><cons sem="G#protein_molecule">CD14</cons> expression</cons> during <cons sem="G#other_name">monocytic differentiation</cons> induced with <cons sem="G#lipid">1 alpha,25-dihydroxyvitamin D3</cons>.</sentence> > 3704c4124 < We have recently cloned the CD14 5' upstream sequence and demonstrated its tissue-specific promoter activity. --- > We have recently cloned the CD14 5' upstream sequence and demonstrated its tissue-specific promoter activity. 3707c4127 < A 3-bp mutation at the distal Sp1-binding site not only eliminates Sp1 interaction, but also abolishes most of the VitD3 induction of CD14 expression. --- > A 3-bp mutation at the distal Sp1-binding site not only eliminates Sp1 interaction, but also abolishes most of the VitD3 induction of CD14 expression. 3717c4137,4139 < DNA-binding and <cons sem="G#other_name">transcriptional regulatory properties</cons> of <cons sem="G#protein_molecule">hepatic leukemia factor</cons> (<cons sem="G#protein_molecule">HLF</cons>) and the t(17;19) <cons sem="G#protein_molecule">acute lymphoblastic leukemia chimera <cons sem="G#protein_molecule">E2A-<cons sem="G#protein_molecule">HLF</cons></cons></cons>. --- > > <sentence>DNA-binding and <cons sem="G#other_name">transcriptional regulatory properties</cons> of <cons sem="G#protein_molecule">hepatic leukemia factor</cons> (<cons sem="G#protein_molecule">HLF</cons>) and the t(17;19) <cons sem="G#protein_molecule">acute lymphoblastic leukemia chimera <cons sem="G#protein_molecule">E2A-<cons sem="G#protein_molecule">HLF</cons></cons></cons>.</sentence> > 3719c4141 < The t(17;19) translocation in acute lymphoblastic leukemias results in creation of E2A-hepatic leukemia factor (HLF) chimeric proteins that contain the DNA-binding and protein dimerization domains of the basic leucine zipper (bZIP) protein HLF fused to a portion of E2A proteins with transcriptional activation properties. --- > The t(17;19) translocation in acute lymphoblastic leukemias results in creation of E2A-hepatic leukemia factor (HLF) chimeric proteins that contain the DNA-binding and protein dimerization domains of the basic leucine zipper (bZIP) protein HLF fused to a portion of E2A proteins with transcriptional activation properties. 3724c4146 < Both wild- type and chimeric HLF proteins displayed transcriptional activator properties in lymphoid and nonlymphoid cells on reporter genes containing HLF or C/EBP consensus binding sites. --- > Both wild- type and chimeric HLF proteins displayed transcriptional activator properties in lymphoid and nonlymphoid cells on reporter genes containing HLF or C/EBP consensus binding sites. 3734c4156,4158 < <cons sem="G#protein_molecule">ZAP-70 tyrosine kinase</cons>, <cons sem="G#protein_molecule">CD45</cons>, and <cons sem="G#protein_family_or_group">T cell receptor</cons> involvement in <cons sem="(AND G#other_name G#other_name)"><cons sem="G#other_name">UV-</cons> and <cons sem="G#other_name">H2O2-</cons><cons sem="G#other_name">induced T cell signal transduction</cons></cons>. --- > > <sentence><cons sem="G#protein_molecule">ZAP-70 tyrosine kinase</cons>, <cons sem="G#protein_molecule">CD45</cons>, and <cons sem="G#protein_family_or_group">T cell receptor</cons> involvement in <cons sem="(AND G#other_name G#other_name)"><cons sem="G#other_name">UV-</cons> and <cons sem="G#other_name">H2O2-</cons><cons sem="G#other_name">induced T cell signal transduction</cons></cons>.</sentence> > 3754c4178,4180 < Inhibition of the <cons sem="G#other_name">differentiation</cons> of <cons sem="G#cell_line">human myeloid cell lines</cons> by <cons sem="G#other_name">redox changes</cons> induced through <cons sem="G#other_name"><cons sem="G#peptide">glutathione</cons> depletion</cons>. --- > > <sentence>Inhibition of the <cons sem="G#other_name">differentiation</cons> of <cons sem="G#cell_line">human myeloid cell lines</cons> by <cons sem="G#other_name">redox changes</cons> induced through <cons sem="G#other_name"><cons sem="G#peptide">glutathione</cons> depletion</cons>.</sentence> > 3766c4192,4194 < <cons sem="G#other_name">Lipopolysaccharide induction</cons> of <cons sem="G#other_name">tissue factor gene expression</cons> in <cons sem="G#cell_type">monocytic cells</cons> is mediated by binding of <cons sem="G#protein_family_or_group">c-Rel/p65 heterodimers</cons> to a <cons sem="G#DNA_domain_or_region">kappa B-like site</cons>. --- > > <sentence><cons sem="G#other_name">Lipopolysaccharide induction</cons> of <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">tissue factor gene</cons> expression</cons> in <cons sem="G#cell_type">monocytic cells</cons> is mediated by binding of <cons sem="G#protein_family_or_group">c-Rel/p65 heterodimers</cons> to a <cons sem="G#DNA_domain_or_region">kappa B-like site</cons>.</sentence> > 3769c4197 < TF is the primary cellular initiator of the coagulation protease cascades. --- > TF is the primary cellular initiator of the coagulation protease cascades. 3772c4200 < In vitro binding studies demonstrated that the TF site bound translated c-Rel and p65 homodimers but not p50/p65 heterodimers or p50 homodimers. --- > In vitro binding studies demonstrated that the TF site bound translated c-Rel and p65 homodimers but not p50/p65 heterodimers or p50 homodimers. 3785c4213,4215 < Inhibition of <cons sem="G#other_name">T cell activation</cons> by the <cons sem="G#protein_family_or_group">extracellular matrix protein</cons> <cons sem="G#protein_molecule">tenascin</cons>. --- > > <sentence>Inhibition of <cons sem="G#other_name">T cell activation</cons> by the <cons sem="G#protein_family_or_group">extracellular matrix protein</cons> <cons sem="G#protein_molecule">tenascin</cons>.</sentence> > 3799c4229,4231 < <cons sem="G#protein_N/A"><cons sem="G#virus">Human immunodeficiency virus type 1</cons> Nef protein</cons> down-regulates <cons sem="G#protein_family_or_group">transcription factors</cons> <cons sem="G#protein_molecule">NF-kappa B</cons> and <cons sem="G#protein_molecule">AP-1</cons> in <cons sem="G#cell_type">human T cells</cons> in vitro after T-cell receptor stimulation. --- > > <sentence><cons sem="G#protein_N/A"><cons sem="G#virus">Human immunodeficiency virus type 1</cons> Nef protein</cons> down-regulates <cons sem="G#protein_family_or_group">transcription factors</cons> <cons sem="G#protein_molecule">NF-kappa B</cons> and <cons sem="G#protein_molecule">AP-1</cons> in <cons sem="G#cell_type">human T cells</cons> in vitro after T-cell receptor stimulation.</sentence> > 3813c4245,4247 < Effects of <cons sem="G#other_organic_compound">alpha-lipoic acid</cons> and <cons sem="G#other_organic_compound">dihydrolipoic acid</cons> on expression of <cons sem="G#DNA_domain_or_region">proto-oncogene c-fos</cons>. --- > > <sentence>Effects of <cons sem="G#other_organic_compound">alpha-lipoic acid</cons> and <cons sem="G#other_organic_compound">dihydrolipoic acid</cons> on expression of <cons sem="G#DNA_domain_or_region">proto-oncogene c-fos</cons>.</sentence> > 3828c4262,4264 < Appraisal of <cons sem="G#other_name">potential therapeutic index</cons> of <cons sem="G#other_organic_compound">antioxidants</cons> on the basis of their in vitro effects on <cons sem="G#other_name"><cons sem="G#virus">HIV</cons> replication</cons> in <cons sem="G#cell_type">monocytes</cons> and <cons sem="G#other_name"><cons sem="G#protein_molecule">interleukin 2</cons>-induced lymphocyte <cons sem="G#other_name">proliferation</cons></cons>. --- > > <sentence>Appraisal of <cons sem="G#other_name">potential therapeutic index</cons> of <cons sem="G#other_organic_compound">antioxidants</cons> on the basis of their in vitro effects on <cons sem="G#other_name"><cons sem="G#virus">HIV</cons> replication</cons> in <cons sem="G#cell_type">monocytes</cons> and <cons sem="G#other_name"><cons sem="G#protein_molecule">interleukin 2</cons>-induced lymphocyte <cons sem="G#other_name">proliferation</cons></cons>.</sentence> > 3833,3834c4269,4270 < Both antioxidants inhibited TNF- or PMA-induced NF-kappa B activity in U1 cells, as well as the sustained NF-kappa B activity permanently induced by the virus itself in chronically HIV-infected U937 cells. < This resulted in only a partial inhibition of TNF- or PMA- induced HIV replication in U1 cells, and no detectable effect on HIV replication in chronically infected U937 cells. --- > Both antioxidants inhibited TNF- or PMA-induced NF-kappa B activity in U1 cells, as well as the sustained NF-kappa B activity permanently induced by the virus itself in chronically HIV-infected U937 cells. > This resulted in only a partial inhibition of TNF- or PMA- induced HIV replication in U1 cells, and no detectable effect on HIV replication in chronically infected U937 cells. 3845c4281,4283 < Isolation and characterization of <cons sem="G#cell_component">gelatinase granules</cons> from <cons sem="G#cell_type">human neutrophils</cons>. --- > > <sentence>Isolation and characterization of <cons sem="G#cell_component">gelatinase granules</cons> from <cons sem="G#cell_type">human neutrophils</cons>.</sentence> > 3862,3863c4300,4303 < Regulation of <cons sem="G#other_name"><cons sem="G#protein_subunit">interleukin-2 receptor alpha chain</cons> expression</cons> and <cons sem="G#other_name"><cons sem="G#protein_molecule">nuclear factor.kappa B</cons> activation</cons> by <cons sem="G#protein_molecule">protein kinase C</cons> in <cons sem="G#cell_type">T lymphocytes</cons>. < Autocrine role of <cons sem="G#protein_molecule">tumor necrosis factor alpha</cons>. --- > > <sentence>Regulation of <cons sem="G#other_name"><cons sem="G#protein_subunit">interleukin-2 receptor alpha chain</cons> expression</cons> and <cons sem="G#other_name"><cons sem="G#protein_molecule">nuclear factor.kappa B</cons> activation</cons> by <cons sem="G#protein_molecule">protein kinase C</cons> in <cons sem="G#cell_type">T lymphocytes</cons>.</sentence> > <sentence>Autocrine role of <cons sem="G#protein_molecule">tumor necrosis factor alpha</cons>.</sentence> > 3865c4305 < The regulation of interleukin-2 receptor alpha chain (IL-2R alpha) expression and nuclear factor (NF) activation by protein kinase C (PKC) in resting T cells, has been studied. --- > The regulation of interleukin-2 receptor alpha chain (IL-2R alpha) expression and nuclear factor (NF) activation by protein kinase C (PKC) in resting T cells, has been studied. 3869,3871c4309,4311 < Furthermore, cyclosporin A, which blocked TNF alpha production induced by PKC, strongly inhibited IL-2R alpha and NF.kappa B activation. < The addition of either TNF alpha or IL-2 partially recovered cyclosporin A-induced IL-2R alpha inhibition, but only TNF alpha completely recovered NF.kappa B activation. < Those results indicate that, in resting T cells, PKC activation has only a triggering role, whereas the endogenously secreted TNF alpha plays an essential role in the quantitative control of the expression of IL-2R alpha chain or NF.kappa B activation. --- > Furthermore, cyclosporin A, which blocked TNF alpha production induced by PKC, strongly inhibited IL-2R alpha and NF.kappa B activation. > The addition of either TNF alpha or IL-2 partially recovered cyclosporin A-induced IL-2R alpha inhibition, but only TNF alpha completely recovered NF.kappa B activation. > Those results indicate that, in resting T cells, PKC activation has only a triggering role, whereas the endogenously secreted TNF alpha plays an essential role in the quantitative control of the expression of IL-2R alpha chain or NF.kappa B activation. 3879c4319,4321 < <cons sem="G#protein_family_or_group">Superantigens</cons> activate <cons sem="G#other_name"><cons sem="G#virus">HIV-1</cons> gene expression</cons> in <cons sem="G#cell_type">monocytic cells</cons>. --- > > <sentence><cons sem="G#protein_family_or_group">Superantigens</cons> activate <cons sem="G#other_name"><cons sem="G#virus">HIV-1</cons> gene expression</cons> in <cons sem="G#cell_type">monocytic cells</cons>.</sentence> > 3883c4325 < Induction of HIV-1- LTR-driven transcription in THP-1 cells by superantigens was associated with the induction of nuclear factor-kappa B DNA-binding activity. --- > Induction of HIV-1- LTR-driven transcription in THP-1 cells by superantigens was associated with the induction of nuclear factor-kappa B DNA-binding activity. 3894c4336,4338 < <cons sem="G#other_name">Mitogen activation</cons> of <cons sem="G#cell_type">human peripheral <cons sem="G#cell_type">T lymphocytes</cons></cons> induces the formation of new <cons sem="G#protein_complex"><cons sem="G#nucleotide">cyclic AMP</cons> response element-binding protein nuclear complexes</cons>. --- > > <sentence><cons sem="G#other_name">Mitogen activation</cons> of <cons sem="G#cell_type">human peripheral <cons sem="G#cell_type">T lymphocytes</cons></cons> induces the formation of new <cons sem="G#protein_complex"><cons sem="G#nucleotide">cyclic AMP</cons> response element-binding protein nuclear complexes</cons>.</sentence> > 3897,3900c4341,4344 < By contrast, many studies have reported that mitogen activation of T cells increases cAMP levels, implying a positive physiological role for cAMP in the activation process. < In the present study we demonstrate that mitogen activation of human peripheral T lymphocytes induces nuclear factors that form complexes with cyclic AMP response element-binding protein (CREB). < Four complexes are identified by the electrophoretic mobility shift assay, two of which are induced by mitogen activation. < All four complexes contain CREB and are bound to the cAMP response element (CRE) core sequence (TGACGTCA), as indicated by antibody and oligonucleotide competition experiments. --- > By contrast, many studies have reported that mitogen activation of T cells increases cAMP levels, implying a positive physiological role for cAMP in the activation process. > In the present study we demonstrate that mitogen activation of human peripheral T lymphocytes induces nuclear factors that form complexes with cyclic AMP response element-binding protein (CREB). > Four complexes are identified by the electrophoretic mobility shift assay, two of which are induced by mitogen activation. > All four complexes contain CREB and are bound to the cAMP response element (CRE) core sequence (TGACGTCA), as indicated by antibody and oligonucleotide competition experiments. 3905c4349 < Induction of new CREB complexes implies a physiological role for cAMP in mitogen activation of T lymphocytes. --- > Induction of new CREB complexes implies a physiological role for cAMP in mitogen activation of T lymphocytes. 3913c4357,4359 < <cons sem="G#other_organic_compound">Alpha-tocopherol</cons> inhibits <cons sem="G#other_name">agonist-induced monocytic cell adhesion</cons> to <cons sem="G#cell_line">cultured human endothelial cells</cons>. --- > > <sentence><cons sem="G#other_organic_compound">Alpha-tocopherol</cons> inhibits <cons sem="G#other_name">agonist-induced monocytic cell adhesion</cons> to <cons sem="G#cell_line">cultured human endothelial cells</cons>.</sentence> > 3924c4370 < Electrophoretic mobility shift assays failed to show an alpha-tcp- induced decrease in activation of this transcription factor after cytokine stimulation. --- > Electrophoretic mobility shift assays failed to show an alpha-tcp- induced decrease in activation of this transcription factor after cytokine stimulation. 3934c4380,4382 < <cons sem="G#cell_type"><cons sem="G#body_part">Central nervous system</cons>-derived cells</cons> express a <cons sem="G#other_name">kappa B-binding activity</cons> that enhances <cons sem="G#other_name"><cons sem="G#virus">human immunodeficiency virus type 1</cons> transcription</cons> in vitro and facilitates <cons sem="G#other_name">TAR-independent transactivation</cons> by <cons sem="G#protein_molecule">Tat</cons>. --- > > <sentence><cons sem="G#cell_type"><cons sem="G#body_part">Central nervous system</cons>-derived cells</cons> express a <cons sem="G#other_name">kappa B-binding activity</cons> that enhances <cons sem="G#other_name"><cons sem="G#virus">human immunodeficiency virus type 1</cons> transcription</cons> in vitro and facilitates <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">TAR</cons>-independent transactivation</cons> by <cons sem="G#protein_molecule">Tat</cons>.</sentence> > 3952c4400,4402 < <cons sem="G#protein_molecule">Human interleukin-13</cons> activates the <cons sem="G#protein_family_or_group">interleukin-4-dependent <cons sem="G#protein_family_or_group">transcription factor</cons></cons> <cons sem="G#protein_molecule">NF-IL4</cons> sharing a <cons sem="G#protein_substructure">DNA binding motif</cons> with an <cons sem="G#protein_molecule">interferon-gamma-induced nuclear binding factor</cons>. --- > > <sentence><cons sem="G#protein_molecule">Human interleukin-13</cons> activates the <cons sem="G#protein_family_or_group">interleukin-4-dependent <cons sem="G#protein_family_or_group">transcription factor</cons></cons> <cons sem="G#protein_molecule">NF-IL4</cons> sharing a <cons sem="G#protein_substructure">DNA binding motif</cons> with an <cons sem="G#protein_molecule">interferon-gamma-induced nuclear binding factor</cons>.</sentence> > 3955c4405 < We provide evidence that in monocytes as well as in T lymphocytes both IL-4 and IL-13 activate the same recently identified transcription factor NF-IL4 which binds to the specific responsive element IL-4RE. --- > We provide evidence that in monocytes as well as in T lymphocytes both IL-4 and IL-13 activate the same recently identified transcription factor NF-IL4 which binds to the specific responsive element >IL-4RE. 3966c4416,4418 < <cons sem="G#virus">Encephalomyocarditis virus</cons> <cons sem="G#cell_component">internal ribosomal entry site</cons> <cons sem="G#other_name">RNA-protein interactions</cons>. --- > > <sentence><cons sem="G#virus">Encephalomyocarditis virus</cons> <cons sem="G#cell_component">internal ribosomal entry site</cons> <cons sem="G#other_name">RNA-protein interactions</cons>.</sentence> > 3984,3985c4436,4439 < A novel <cons sem="G#protein_family_or_group">heterodimerization partner</cons> for <cons sem="G#protein_family_or_group">thyroid hormone receptor</cons>. < <cons sem="G#protein_molecule">Peroxisome proliferator-activated receptor</cons>. --- > > <sentence>A novel <cons sem="G#protein_family_or_group">heterodimerization partner</cons> for <cons sem="G#protein_family_or_group">thyroid hormone receptor</cons>. > <cons sem="G#protein_molecule">Peroxisome proliferator-activated receptor</cons>.</sentence> > 4000c4454,4456 < Comparison of <cons sem="G#other_organic_compound">retinoic acid</cons> and <cons sem="G#other_organic_compound">phorbol myristate acetate</cons> as inducers of <cons sem="G#other_name">monocytic differentiation</cons>. --- > > <sentence>Comparison of <cons sem="G#other_organic_compound">retinoic acid</cons> and <cons sem="G#other_organic_compound">phorbol myristate acetate</cons> as inducers of <cons sem="G#other_name">monocytic differentiation</cons>.</sentence> > 4007c4463 < Their effects on the src- family tyrosine kinase genes were different: hck expression was similarly induced by these agents but lyn expression was stronger and more rapid after RA treatment. --- > Their effects on the src- family tyrosine kinase genes were different: hck expression was similarly induced by these agents but lyn expression was stronger and more rapid after RA treatment. 4018c4474,4476 < An active <cons sem="G#protein_molecule">v-abl protein <cons sem="G#amino_acid_monomer">tyrosine</cons> kinase</cons> blocks <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">immunoglobulin light- chain gene</cons> rearrangement</cons>. --- > > <sentence>An active <cons sem="G#protein_molecule">v-abl protein <cons sem="G#amino_acid_monomer">tyrosine</cons> kinase</cons> blocks <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">immunoglobulin light- chain gene</cons> rearrangement</cons>.</sentence> > 4020c4478 < Lymphoid cells transformed by Abelson murine leukemia virus have provided one of the classic models for study of early B-cell development and immunoglobulin rearrangement. --- > Lymphoid cells transformed by Abelson murine leukemia virus have provided one of the classic models for study of early B-cell development and immunoglobulin rearrangement. 4027c4485 < Together these data demonstrate that the v-abl protein specifically interferes with light- chain gene rearrangement by suppressing at least two pathways essential for this stage of B-cell differentiation and suggest that tyrosine phosphorylation is important in regulating RAG gene expression --- > Together these data demonstrate that the v-abl protein specifically interferes with light- chain gene rearrangement by suppressing at least two pathways essential for this stage of B-cell differentiation and suggest that tyrosine phosphorylation is important in regulating RAG gene expression 4035c4493,4495 < <cons sem="G#other_name"><cons sem="G#atom">Calcium</cons> signalling</cons> in <cons sem="G#cell_type">T cells</cons> stimulated by a <cons sem="G#protein_family_or_group">cyclophilin B-binding protein</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#atom">Calcium</cons> signalling</cons> in <cons sem="G#cell_type">T cells</cons> stimulated by a <cons sem="G#protein_family_or_group">cyclophilin B-binding protein</cons>.</sentence> > 4050c4510,4512 < Expression and genomic configuration of <cons sem="G#protein_molecule">GM-CSF</cons>, <cons sem="G#protein_molecule">IL-3</cons>, <cons sem="G#protein_molecule">M-CSF receptor</cons> (<cons sem="G#protein_molecule">C- FMS</cons>), <cons sem="G#DNA_domain_or_region">early growth response gene-1</cons> (<cons sem="G#DNA_domain_or_region">EGR-1</cons>) and <cons sem="G#DNA_domain_or_region">M-CSF genes</cons> in <cons sem="G#other_name">primary myelodysplastic syndromes.</cons> --- > > <sentence>Expression and genomic configuration of <cons sem="G#protein_molecule">GM-CSF</cons>, <cons sem="G#protein_molecule">IL-3</cons>, <cons sem="G#protein_molecule">M-CSF receptor</cons> (<cons sem="G#protein_molecule">C- FMS</cons>), <cons sem="G#DNA_domain_or_region">early growth response gene-1</cons> (<cons sem="G#DNA_domain_or_region">EGR-1</cons>) and <cons sem="G#DNA_domain_or_region">M-CSF genes</cons> in <cons sem="G#other_name">primary myelodysplastic syndromes.</cons></sentence> > 4068c4530,4532 < A novel <cons sem="G#DNA_family_or_group">human homeobox gene</cons> distantly related to <cons sem="G#DNA_domain_or_region">proboscipedia</cons> is expressed in <cons sem="(AND G#tissue G#tissue)"><cons>lymphoid</cons> and <cons>pancreatic</cons> <cons>tissues</cons></cons>. --- > > <sentence>A novel <cons sem="G#DNA_family_or_group">human homeobox gene</cons> distantly related to <cons sem="G#DNA_domain_or_region">proboscipedia</cons> is expressed in <cons sem="(AND G#tissue G#tissue)"><cons>lymphoid</cons> and <cons>pancreatic</cons> <cons>tissues</cons></cons>.</sentence> > 4088c4552,4554 < <cons sem="G#protein_molecule"><cons sem="G#virus">Human immunodeficiency virus type 1</cons> Tat</cons> upregulates <cons sem="G#other_name"><cons sem="G#protein_molecule">interleukin-2</cons> secretion</cons> in <cons sem="G#cell_type">activated T cells</cons>. --- > > <sentence><cons sem="G#protein_molecule"><cons sem="G#virus">Human immunodeficiency virus type 1</cons> Tat</cons> upregulates <cons sem="G#other_name"><cons sem="G#protein_molecule">interleukin-2</cons> secretion</cons> in <cons sem="G#cell_type">activated T cells</cons>.</sentence> > 4106c4572,4574 < Activation of <cons sem="G#protein_molecule">nuclear factor kappa B</cons> in <cons sem="G#cell_type">human lymphoblastoid cells</cons> by <cons sem="G#other_name">low-dose ionizing radiation</cons>. --- > > <sentence>Activation of <cons sem="G#protein_molecule">nuclear factor kappa B</cons> in <cons sem="G#cell_type">human lymphoblastoid cells</cons> by <cons sem="G#other_name">low-dose ionizing radiation</cons>.</sentence> > 4123c4591,4593 < Alternative splicing of <cons sem="G#RNA_family_or_group">RNA transcripts</cons> encoded by the <cons sem="G#DNA_domain_or_region">murine p105 NF- kappa B gene</cons> generates <cons sem="G#protein_family_or_group">I kappa B gamma isoforms</cons> with different <cons sem="G#other_name">inhibitory activities</cons>. --- > > <sentence>Alternative splicing of <cons sem="G#RNA_family_or_group">RNA transcripts</cons> encoded by the <cons sem="G#DNA_domain_or_region">murine p105 NF- kappa B gene</cons> generates <cons sem="G#protein_family_or_group">I kappa B gamma isoforms</cons> with different <cons sem="G#other_name">inhibitory activities</cons>.</sentence> > 4140c4610,4612 < Structure and expression of the <cons sem="G#DNA_domain_or_region">human GATA3 gene</cons>. --- > > <sentence>Structure and expression of the <cons sem="G#DNA_domain_or_region">human GATA3 gene</cons>.</sentence> > 4156c4628,4630 < Characterization of the <cons sem="G#DNA_family_or_group">human gene</cons> encoding <cons sem="G#protein_molecule">LBR</cons>, an <cons sem="G#protein_family_or_group">integral protein</cons> of the <cons sem="G#cell_component">nuclear envelope inner membrane</cons>. --- > > <sentence>Characterization of the <cons sem="G#DNA_family_or_group">human gene</cons> encoding <cons sem="G#protein_molecule">LBR</cons>, an <cons sem="G#protein_family_or_group">integral protein</cons> of the <cons sem="G#cell_component">nuclear envelope inner membrane</cons>.</sentence> > 4173c4647,4649 < <cons sem="G#other_name">Retinoic acid-induced expression</cons> of <cons sem="G#protein_molecule">CD38 antigen</cons> in <cons sem="G#cell_type">myeloid cells</cons> is mediated through <cons sem="G#protein_molecule">retinoic acid receptor-alpha</cons>. --- > > <sentence><cons sem="G#other_name">Retinoic acid-induced expression</cons> of <cons sem="G#protein_molecule">CD38 antigen</cons> in <cons sem="G#cell_type">myeloid cells</cons> is mediated through <cons sem="G#protein_molecule">retinoic acid receptor-alpha</cons>.</sentence> > 4183c4659 < Induction of CD38 in acute promyelocytic and acute myeloblastic leukemia cells was independent of ATRA-induced cytodifferentiation. --- > Induction of CD38 in acute promyelocytic and acute myeloblastic leukemia cells was independent of ATRA-induced cytodifferentiation. 4194c4670,4672 < Some <cons sem="G#other_organic_compound">antioxidants</cons> inhibit, in a co-ordinate fashion, the production of <cons sem="G#protein_molecule">tumor necrosis factor-alpha</cons>, <cons sem="G#protein_molecule">IL-beta</cons>, and <cons sem="G#protein_molecule">IL-6</cons> by <cons sem="G#cell_type">human peripheral blood mononuclear cells</cons>. --- > > <sentence>Some <cons sem="G#other_organic_compound">antioxidants</cons> inhibit, in a co-ordinate fashion, the production of <cons sem="G#protein_molecule">tumor necrosis factor-alpha</cons>, <cons sem="G#protein_molecule">IL-beta</cons>, and <cons sem="G#protein_molecule">IL-6</cons> by <cons sem="G#cell_type">human peripheral blood mononuclear cells</cons>.</sentence> > 4197,4198c4675,4676 < Inhibition of cytokine production was gene selective and not due to general effects on protein synthesis. < Inhibition of cytokine production by PBMC was observed also when other inducers were used (staphylococci, silica, zymosan). --- > Inhibition of cytokine production was gene selective and not due to general effects on protein synthesis. > Inhibition of cytokine production by PBMC was observed also when other inducers were used (staphylococci, silica, zymosan). 4201c4679 < Antioxidant-mediated inhibition of cytokine production was correlated with low levels of the corresponding messenger RNAs. --- > Antioxidant-mediated inhibition of cytokine production was correlated with low levels of the corresponding messenger RNAs. 4214c4692,4694 < An <cons sem="G#protein_family_or_group">interleukin-4-induced transcription factor</cons>: <cons sem="G#protein_molecule">IL-4 Stat</cons>. --- > > <sentence>An <cons sem="G#protein_family_or_group">interleukin-4-induced transcription factor</cons>: <cons sem="G#protein_molecule">IL-4 Stat</cons>.</sentence> > 4231c4711,4713 < Evaluation of the <cons sem="G#tissue">respiratory epithelium</cons> of normals and individuals with <cons sem="G#other_name">cystic fibrosis</cons> for the presence of <cons sem="G#DNA_domain_or_region">adenovirus E1a sequences</cons> relevant to the use of <cons sem="G#virus">E1a- adenovirus vectors</cons> for <cons sem="G#other_name">gene therapy</cons> for the <cons sem="G#other_name">respiratory manifestations</cons> of <cons sem="G#other_name">cystic fibrosis</cons>. --- > > <sentence>Evaluation of the <cons sem="G#tissue">respiratory epithelium</cons> of normals and individuals with <cons sem="G#other_name">cystic fibrosis</cons> for the presence of <cons sem="G#DNA_domain_or_region">adenovirus E1a sequences</cons> relevant to the use of <cons sem="G#virus">E1a- adenovirus vectors</cons> for <cons sem="G#other_name">gene therapy</cons> for the <cons sem="G#other_name">respiratory manifestations</cons> of <cons sem="G#other_name">cystic fibrosis</cons>.</sentence> > 4248c4730,4732 < <cons sem="G#other_name">Leiomyosarcoma</cons> of the <cons sem="G#body_part">vulva</cons>: report of a case. --- > > <sentence><cons sem="G#other_name">Leiomyosarcoma</cons> of the <cons sem="G#body_part">vulva</cons>: report of a case.</sentence> > 4264c4748,4750 < Stimulation of <cons sem="G#other_name">HIV replication</cons> in <cons sem="G#cell_type">mononuclear phagocytes</cons> by <cons sem="G#protein_molecule">leukemia inhibitory factor</cons>. --- > > <sentence>Stimulation of <cons sem="G#other_name">HIV replication</cons> in <cons sem="G#cell_type">mononuclear phagocytes</cons> by <cons sem="G#protein_molecule">leukemia inhibitory factor</cons>.</sentence> > 4267c4753 < LIF induced a dose-dependent increase in p24 antigen production in the chronically infected promonocytic cell line U1. --- > LIF induced a dose-dependent increase in p24 antigen production in the chronically infected promonocytic cell line U1. 4272c4758 < The DNA binding protein NF-kB is a central mediator in cytokine activation of HIV transcription. --- > The DNA binding protein NF-kB is a central mediator in cytokine activation of HIV transcription. 4287c4773,4775 < Mechanisms involved in the inhibition of growth of a <cons sem="G#cell_line">human B lymphoma cell line</cons>, <cons sem="G#cell_line">B104</cons>, by <cons sem="G#protein_family_or_group">anti-MHC class II antibodies</cons>. --- > > <sentence>Mechanisms involved in the inhibition of growth of a <cons sem="G#cell_line">human B lymphoma cell line</cons>, <cons sem="G#cell_line">B104</cons>, by <cons sem="G#protein_family_or_group">anti-MHC class II antibodies</cons>.</sentence> > 4303c4791,4793 < Functional block for <cons sem="G#other_name"><cons sem="G#lipid">1 alpha,25-dihydroxyvitamin D3</cons>-mediated gene regulation</cons> in <cons sem="G#cell_type">human B lymphocytes</cons>. --- > > <sentence>Functional block for <cons sem="G#other_name"><cons sem="G#lipid">1 alpha,25-dihydroxyvitamin D3</cons>-mediated gene regulation</cons> in <cons sem="G#cell_type">human B lymphocytes</cons>.</sentence> > 4319c4809,4811 < Positive and negative regulation of <cons sem="G#protein_molecule">IL-2</cons> <cons sem="G#other_name">gene expression</cons>: role of multiple regulatory sites. --- > > <sentence>Positive and negative regulation of <cons sem="G#protein_molecule">IL-2</cons> <cons sem="G#other_name">gene expression</cons>: role of multiple regulatory sites.</sentence> > 4337c4829,4831 < <cons sem="G#protein_molecule">Sp1</cons> is a critical factor for the monocytic specific expression of <cons sem="G#protein_molecule">human CD14</cons>. --- > > <sentence><cons sem="G#protein_molecule">Sp1</cons> is a critical factor for the monocytic specific expression of <cons sem="G#protein_molecule">human CD14</cons>.</sentence> > 4355c4849,4851 < The <cons sem="(AND G#DNA_domain_or_region G#DNA_domain_or_region)"><cons>interleukin-8 AP-1</cons> and <cons>kappa B-like</cons> <cons>sites</cons></cons> are genetic end targets of <cons sem="G#other_name">FK506-sensitive pathway</cons> accompanied by <cons sem="G#other_name"><cons sem="G#atom">calcium</cons> mobilization</cons>. --- > > <sentence>The <cons sem="(AND G#DNA_domain_or_region G#DNA_domain_or_region)"><cons>interleukin-8 AP-1</cons> and <cons>kappa B-like</cons> <cons>sites</cons></cons> are genetic end targets of <cons sem="G#other_name">FK506-sensitive pathway</cons> accompanied by <cons sem="G#other_name"><cons sem="G#atom">calcium</cons> mobilization</cons>.</sentence> > 4372c4868,4870 < <cons sem="G#protein_domain_or_region">Androgen binding sites</cons> in <cons sem="G#cell_type">peripheral human mononuclear leukocytes</cons> of <cons sem="G#multi_cell">healthy males</cons> and <cons sem="G#multi_cell">females</cons>. --- > > <sentence><cons sem="G#protein_domain_or_region">Androgen binding sites</cons> in <cons sem="G#cell_type">peripheral human mononuclear leukocytes</cons> of <cons sem="G#multi_cell">healthy males</cons> and <cons sem="G#multi_cell">females</cons>.</sentence> > 4391c4889,4891 < Induction of <cons sem="G#other_name"><cons sem="G#protein_molecule">IL-8</cons> expression</cons> in <cons sem="G#cell_type">T cells</cons> uses the <cons sem="G#other_name"><cons sem="G#protein_molecule">CD28</cons> costimulatory pathway</cons>. --- > > <sentence>Induction of <cons sem="G#other_name"><cons sem="G#protein_molecule">IL-8</cons> expression</cons> in <cons sem="G#cell_type">T cells</cons> uses the <cons sem="G#other_name"><cons sem="G#protein_molecule">CD28</cons> costimulatory pathway</cons>.</sentence> > 4406c4906,4908 < <cons sem="G#other_name"><cons sem="G#protein_family_or_group">MHC class II</cons> signaling</cons> in <cons sem="G#other_name"><cons sem="G#cell_type">B-cell</cons> activation</cons> [see comments] --- > > <sentence><cons sem="G#other_name"><cons sem="G#protein_family_or_group">MHC class II</cons> signaling</cons> in <cons sem="G#other_name"><cons sem="G#cell_type">B-cell</cons> activation</cons> [see comments]</sentence> > 4419,4420c4921,4924 < Effects of <cons sem="G#lipid">glucocorticoids</cons> in <cons sem="G#other_name">rheumatoid arthritis</cons>. < Diminished <cons sem="G#protein_family_or_group">glucocorticoid receptors</cons> do not result in <cons sem="G#other_name"><cons sem="G#lipid">glucocorticoid</cons> resistance</cons>. --- > > <sentence>Effects of <cons sem="G#lipid">glucocorticoids</cons> in <cons sem="G#other_name">rheumatoid arthritis</cons>.</sentence> > <sentence>Diminished <cons sem="G#protein_family_or_group">glucocorticoid receptors</cons> do not result in <cons sem="G#other_name"><cons sem="G#lipid">glucocorticoid</cons> resistance</cons>.</sentence> > 4438c4942,4944 < <cons sem="G#other_name">Arrested development</cons>: understanding <cons sem="G#DNA_domain_or_region">v-abl</cons>. --- > > <sentence><cons sem="G#other_name">Arrested development</cons>: understanding <cons sem="G#DNA_domain_or_region">v-abl</cons>.</sentence> > 4451c4957,4959 < <cons sem="G#protein_family_or_group">Corticosteroid receptors</cons> in <cons sem="G#cell_type">lymphocytes</cons>: a possible marker of <cons sem="G#other_name">brain involution</cons>? --- > > <sentence><cons sem="G#protein_family_or_group">Corticosteroid receptors</cons> in <cons sem="G#cell_type">lymphocytes</cons>: a possible marker of <cons sem="G#other_name">brain involution</cons>?</sentence> > 4469c4977,4979 < <cons sem="G#other_organic_compound">All-trans retinoic acid</cons> and <cons sem="G#lipid">1 alpha,25-dihydroxyvitamin D3</cons> co-operate to promote <cons sem="G#other_name">differentiation</cons> of the <cons sem="G#cell_line">human promyeloid leukemia cell line</cons> <cons sem="G#cell_line">HL60</cons> to <cons sem="G#cell_type">monocytes</cons>. --- > > <sentence><cons sem="G#other_organic_compound">All-trans retinoic acid</cons> and <cons sem="G#lipid">1 alpha,25-dihydroxyvitamin D3</cons> co-operate to promote <cons sem="G#other_name">differentiation</cons> of the <cons sem="G#cell_line">human promyeloid leukemia cell line</cons> <cons sem="G#cell_line">HL60</cons> to <cons sem="G#cell_type">monocytes</cons>.</sentence> > 4488c4998,5000 < [An overexpression of <cons sem="G#protein_molecule">retinoic acid receptor alpha</cons> blocks <cons sem="G#other_name"><cons sem="G#cell_type">myeloid cell</cons> differentiation</cons> at the <cons sem="G#other_name">promyelocyte stage</cons>] --- > > <sentence>[An overexpression of <cons sem="G#protein_molecule">retinoic acid receptor alpha</cons> blocks <cons sem="G#other_name"><cons sem="G#cell_type">myeloid cell</cons> differentiation</cons> at the <cons sem="G#other_name">promyelocyte stage</cons>]</sentence> > 4509c5021,5023 < Hypoxic induction of <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">interleukin-8</cons> gene</cons> expression</cons> in <cons sem="G#cell_type">human endothelial cells</cons>. --- > > <sentence>Hypoxic induction of <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">interleukin-8</cons> gene</cons> expression</cons> in <cons sem="G#cell_type">human endothelial cells</cons>.</sentence> > 4527c5041,5043 < <cons sem="G#protein_molecule">Thrombin</cons> and <cons sem="G#peptide"><cons sem="G#protein_family_or_group">thrombin receptor</cons> agonist peptide</cons> induce early events of <cons sem="G#other_name">T cell activation</cons> and synergize with <cons sem="G#other_name">TCR cross-linking</cons> for <cons sem="G#other_name"><cons sem="G#protein_molecule">CD69</cons> expression</cons> and interleukin 2 production. --- > > <sentence><cons sem="G#protein_molecule">Thrombin</cons> and <cons sem="G#peptide"><cons sem="G#protein_family_or_group">thrombin receptor</cons> agonist peptide</cons> induce early events of <cons sem="G#other_name">T cell activation</cons> and synergize with <cons sem="G#other_name"><cons sem="G#protein_family_or_group">TCR</cons> cross-linking</cons> for <cons sem="G#other_name"><cons sem="G#protein_molecule">CD69</cons> expression</cons> and interleukin 2 production.</sentence> > 4549c5065,5067 < <cons sem="G#other_name">Stress response</cons> of <cons sem="G#cell_type">senescent T lymphocytes</cons>: reduced <cons sem="G#protein_molecule">hsp70</cons> is independent of the <cons sem="G#other_name">proliferative block</cons>. --- > > <sentence><cons sem="G#other_name">Stress response</cons> of <cons sem="G#cell_type">senescent T lymphocytes</cons>: reduced <cons sem="G#protein_molecule">hsp70</cons> is independent of the <cons sem="G#other_name">proliferative block</cons>.</sentence> > 4563c5081,5083 < Involvement of <cons sem="G#protein_molecule">phospholipase D</cons> in the activation of <cons sem="G#protein_molecule">transcription factor <cons sem="G#protein_molecule">AP-1</cons></cons> in <cons sem="G#cell_line">human T lymphoid <cons sem="G#cell_line">Jurkat cells</cons></cons>. --- > > <sentence>Involvement of <cons sem="G#protein_molecule">phospholipase D</cons> in the activation of <cons sem="G#protein_molecule">transcription factor <cons sem="G#protein_molecule">AP-1</cons></cons> in <cons sem="G#cell_line">human T lymphoid <cons sem="G#cell_line">Jurkat cells</cons></cons>.</sentence> > 4569c5089 < Wortmannin, an inhibitor of receptor-coupled PLD activation, blocked the anti-CD3-induced increases in both PLD activity and AP-1 enhancer activity. --- > Wortmannin, an inhibitor of receptor-coupled PLD activation, blocked the anti-CD3-induced increases in both PLD activity and AP-1 enhancer activity. 4572c5092 < However, this anti-CD3-mediated response was not inhibited by neomycin, an inhibitor of phosphoinositide hydrolysis. --- > However, this anti-CD3-mediated response was not inhibited by neomycin, an inhibitor of phosphoinositide hydrolysis. 4574c5094 < Furthermore, the PA- and the anti-CD3-induced increases in AP-1 enhancer activity were blocked by the presence of PKC inhibitors or by PKC down-regulation. --- > Furthermore, the PA- and the anti-CD3-induced increases in AP-1 enhancer activity were blocked by the presence of PKC inhibitors or by PKC down-regulation. 4584c5104,5106 < Upregulation of <cons sem="G#DNA_domain_or_region">bcl-2</cons> by the <cons sem="G#protein_molecule"><cons sem="G#virus">Epstein-Barr virus</cons> latent membrane protein</cons> <cons sem="G#protein_molecule">LMP1</cons>: a <cons sem="G#other_name">B-cell-specific response</cons> that is delayed relative to <cons sem="G#other_name"><cons sem="G#protein_molecule">NF-kappa B</cons> activation</cons> and to induction of <cons sem="G#protein_family_or_group">cell surface markers</cons>. --- > > <sentence>Upregulation of <cons sem="G#DNA_domain_or_region">bcl-2</cons> by the <cons sem="G#protein_molecule"><cons sem="G#virus">Epstein-Barr virus</cons> latent membrane protein</cons> <cons sem="G#protein_molecule">LMP1</cons>: a <cons sem="G#other_name">B-cell-specific response</cons> that is delayed relative to <cons sem="G#other_name"><cons sem="G#protein_molecule">NF-kappa B</cons> activation</cons> and to induction of <cons sem="G#protein_family_or_group">cell surface markers</cons>.</sentence> > 4603c5125,5127 < <cons sem="G#other_name">Long-term <cons sem="G#other_name"><cons sem="G#lipid">inositol phosphate</cons> release</cons></cons>, but not <cons sem="G#other_name"><cons sem="G#protein_molecule"><cons sem="G#amino_acid_monomer">tyrosine</cons> kinase</cons> activity</cons>, correlates with <cons sem="G#other_name"><cons sem="G#protein_molecule">IL-2</cons> secretion</cons> and <cons sem="G#other_name"><cons sem="G#protein_molecule">NF-AT</cons> induction</cons> in <cons sem="G#cell_line">anti-CD3- activated peripheral human T lymphocytes</cons>. --- > > <sentence><cons sem="G#other_name">Long-term <cons sem="G#other_name"><cons sem="G#lipid">inositol phosphate</cons> release</cons></cons>, but not <cons sem="G#other_name"><cons sem="G#protein_molecule"><cons sem="G#amino_acid_monomer">tyrosine</cons> kinase</cons> activity</cons>, correlates with <cons sem="G#other_name"><cons sem="G#protein_molecule">IL-2</cons> secretion</cons> and <cons sem="G#other_name"><cons sem="G#protein_molecule">NF-AT</cons> induction</cons> in <cons sem="G#cell_line">anti-CD3- activated peripheral human T lymphocytes</cons>.</sentence> > 4607c5131 < To model effective versus ineffective CD3-mediated stimulation in peripheral T cells, we used two anti-CD3 mAbs that differ in their ability to stimulate purified T cells: OKT3, which causes early second messenger generation but is unable to activate T cells without a second signal, and 64.1, which stimulates T cell proliferation on its own. --- > To model effective versus ineffective CD3-mediated stimulation in peripheral T cells, we used two anti-CD3 mAbs that differ in their ability to stimulate purified T cells: OKT3, which causes early second messenger generation but is unable to activate T cells without a second signal, and 64.1, which stimulates T cell proliferation on its own. 4610c5134 < To tie these events to gene activation, we measured NF-kappa B and NF-AT activity in the nucleus after anti-CD3 stimulation. --- > To tie these events to gene activation, we measured NF-kappa B and NF-AT activity in the nucleus after anti-CD3 stimulation. 4622c5146,5148 < <cons sem="(AND G#other_name G#other_name G#other_name G#other_name)"><cons>HLA-DR-</cons>, <cons>CD33+</cons>, <cons>CD56+</cons>, <cons>CD16-</cons> <cons>myeloid/natural killer cell acute leukemia</cons></cons>: a previously unrecognized form of <cons sem="G#other_name">acute leukemia</cons> potentially misdiagnosed as <cons sem="G#other_name">French-American-British acute myeloid leukemia-M3</cons> [see comments] --- > > <sentence><cons sem="(AND G#other_name G#other_name G#other_name G#other_name)"><cons>HLA-DR-</cons>, <cons>CD33+</cons>, <cons>CD56+</cons>, <cons>CD16-</cons> <cons>myeloid/natural killer cell acute leukemia</cons></cons>: a previously unrecognized form of <cons sem="G#other_name">acute leukemia</cons> potentially misdiagnosed as <cons sem="G#other_name">French-American-British acute myeloid leukemia-M3</cons> [see comments]</sentence> > 4625c5151 < From a consecutive series of 350 cases of adult de novo acute myeloid leukemia (AML), we identified 20 cases (6%) with a unique immunophenotype: CD33+, CD56+, CD11a+, CD13lo, CD15lo, CD34+/-, HLA-DR- , CD16-. --- > From a consecutive series of 350 cases of adult de novo acute myeloid leukemia (AML), we identified 20 cases (6%) with a unique immunophenotype: CD33+, CD56+, CD11a+, CD13lo, CD15lo, CD34+/-, HLA-DR- , CD16-. 4628c5154 < Leukemic blasts in the majority of cases shared unique morphologic features (deeply invaginated nuclear membranes, scant cytoplasm with fine azurophilic granularity, and finely granular Sudan black B and myeloperoxidase cytochemical reactivity) that were remarkably similar to those of acute promyelocytic leukemia (APL); particularly the microgranular variant (FAB AML-M3v). --- > Leukemic blasts in the majority of cases shared unique morphologic features (deeply invaginated nuclear membranes, scant cytoplasm with fine azurophilic granularity, and finely granular Sudan black B and myeloperoxidase cytochemical reactivity) that were remarkably similar to those of acute promyelocytic leukemia (APL); particularly the microgranular variant (FAB AML-M3v). 4631c5157 < Four of 6 cases tested showed functional NK cell-mediated cytotoxicity, suggesting a relationship between these unique CD33+, CD56+, CD16- acute leukemias and normal CD56+, CD16- NK precursor cells. --- > Four of 6 cases tested showed functional NK cell-mediated cytotoxicity, suggesting a relationship between these unique CD33+, CD56+, CD16- acute leukemias and normal CD56+, CD16- NK precursor cells. 4642c5168,5170 < <cons sem="G#protein_molecule">IL-4</cons> down-regulates <cons sem="G#protein_molecule">IL-2</cons>-, <cons sem="G#protein_molecule">IL-3</cons>-, and <cons sem="G#protein_molecule">GM-CSF</cons>-induced cytokine gene expression in <cons sem="G#tissue">peripheral blood</cons> monocytes. --- > > <sentence><cons sem="G#protein_molecule">IL-4</cons> down-regulates <cons sem="G#protein_molecule">IL-2</cons>-, <cons sem="G#protein_molecule">IL-3</cons>-, and <cons sem="G#protein_molecule">GM-CSF</cons>-induced cytokine gene expression in <cons sem="G#tissue">peripheral blood</cons> monocytes.</sentence> > 4659c5187,5189 < Induction of <cons sem="G#DNA_molecule">proto-oncogene</cons> and <cons sem="G#other_name"><cons sem="G#protein_family_or_group">cytokine</cons> expression</cons> in human <cons sem="G#tissue">peripheral blood</cons> <cons sem="G#cell_type">monocytes</cons> and the <cons sem="G#cell_line">monocytic cell line</cons> <cons sem="G#cell_line">THP-1</cons> after stimulation with <cons sem="G#other_organic_compound">mycoplasma-derived material</cons> <cons sem="G#other_organic_compound">MDHM</cons>. --- > > <sentence>Induction of <cons sem="G#DNA_molecule">proto-oncogene</cons> and <cons sem="G#other_name"><cons sem="G#protein_family_or_group">cytokine</cons> expression</cons> in human <cons sem="G#tissue">peripheral blood</cons> <cons sem="G#cell_type">monocytes</cons> and the <cons sem="G#cell_line">monocytic cell line</cons> <cons sem="G#cell_line">THP-1</cons> after stimulation with <cons sem="G#other_organic_compound">mycoplasma-derived material</cons> <cons sem="G#other_organic_compound">MDHM</cons>.</sentence> > 4681c5211,5213 < <cons sem="G#protein_family_or_group">Novel membrane receptors</cons> for <cons sem="G#lipid">aldosterone</cons> in <cons sem="G#cell_type">human lymphocytes</cons>: a <cons sem="G#protein_molecule">50 kDa protein</cons> on <cons sem="G#other_name">SDS-PAGE</cons>. --- > > <sentence><cons sem="G#protein_family_or_group">Novel membrane receptors</cons> for <cons sem="G#lipid">aldosterone</cons> in <cons sem="G#cell_type">human lymphocytes</cons>: a <cons sem="G#protein_molecule">50 kDa protein</cons> on <cons sem="G#other_name">SDS-PAGE</cons>.</sentence> > 4699c5231,5233 < A <cons sem="G#DNA_family_or_group">transcriptional regulatory element</cons> is associated with a <cons sem="G#DNA_domain_or_region">nuclease- hypersensitive site</cons> in the <cons sem="G#DNA_domain_or_region">pol gene</cons> of <cons sem="G#virus">human immunodeficiency virus type 1</cons>. --- > > <sentence>A <cons sem="G#DNA_family_or_group">transcriptional regulatory element</cons> is associated with a <cons sem="G#DNA_domain_or_region">nuclease- hypersensitive site</cons> in the <cons sem="G#DNA_domain_or_region">pol gene</cons> of <cons sem="G#virus">human immunodeficiency virus type 1</cons>.</sentence> > 4718c5252,5254 < Expression of <cons sem="G#DNA_domain_or_region">v-src</cons> in <cons sem="G#cell_type">T cells</cons> correlates with nuclear expression of <cons sem="G#protein_molecule">NF- kappa B</cons>. --- > > <sentence>Expression of <cons sem="G#DNA_domain_or_region">v-src</cons> in <cons sem="G#cell_type">T cells</cons> correlates with nuclear expression of <cons sem="G#protein_molecule">NF- kappa B</cons>.</sentence> > 4728c5264 < The implications for T cell receptor signaling and HIV-1 gene expression are considered. --- > The implications for T cell receptor signaling and HIV-1 gene expression are considered. 4736c5272,5274 < trans-activation of the <cons sem="G#DNA_domain_or_region">HIV promoter</cons> by a cDNA and its genomic clones of <cons sem="G#virus">human herpesvirus-6</cons>. --- > > <sentence>trans-activation of the <cons sem="G#DNA_domain_or_region">HIV promoter</cons> by a cDNA and its genomic clones of <cons sem="G#virus">human herpesvirus-6</cons>.</sentence> > 4747c5285 < By using HIV LTR deletion mutants, the NF- kappa B binding sites were found to be critical for response to the pCD41 trans-activation --- > By using HIV LTR deletion mutants, the NF- kappa B binding sites were found to be critical for response to the pCD41 trans-activation 4755c5293,5295 < <cons sem="G#other_name"><cons sem="G#protein_molecule">CD14</cons>-mediated translocation</cons> of <cons sem="G#protein_molecule">nuclear factor-kappa B</cons> induced by <cons sem="G#lipid">lipopolysaccharide</cons> does not require <cons sem="G#other_name"><cons sem="G#protein_molecule"><cons sem="G#amino_acid_monomer">tyrosine</cons> kinase</cons> activity</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#protein_molecule">CD14</cons>-mediated translocation</cons> of <cons sem="G#protein_molecule">nuclear factor-kappa B</cons> induced by <cons sem="G#lipid">lipopolysaccharide</cons> does not require <cons sem="G#other_name"><cons sem="G#protein_molecule"><cons sem="G#amino_acid_monomer">tyrosine</cons> kinase</cons> activity</cons>.</sentence> > 4776c5316,5318 < Signals transduced through the <cons sem="G#protein_molecule">CD4 molecule</cons> on <cons sem="G#cell_type">T lymphocytes</cons> activate <cons sem="G#protein_molecule">NF-kappa B</cons>. --- > > <sentence>Signals transduced through the <cons sem="G#protein_molecule">CD4 molecule</cons> on <cons sem="G#cell_type">T lymphocytes</cons> activate <cons sem="G#protein_molecule">NF-kappa B</cons>.</sentence> > 4782c5324 < The gp160-mediated activation of NF-kappa B in CD4 positive T cells may be involved in biological effects, e.g., enhanced HIV replication, hypergammaglobulinemia, increased cytokine secretion, hypercellularity in bone marrow and apoptosis. --- > The gp160-mediated activation of NF-kappa B in CD4 positive T cells may be involved in biological effects, e.g., enhanced HIV replication, hypergammaglobulinemia, increased cytokine secretion, hypercellularity in bone marrow and apoptosis. 4790c5332,5334 < No evidence for the expression of the <cons sem="G#protein_family_or_group">progesterone receptor</cons> on <cons sem="G#cell_type">peripheral blood lymphocytes</cons> during <cons sem="G#other_name">pregnancy</cons> [see comments] --- > > <sentence>No evidence for the expression of the <cons sem="G#protein_family_or_group">progesterone receptor</cons> on <cons sem="G#cell_type">peripheral blood lymphocytes</cons> during <cons sem="G#other_name">pregnancy</cons> [see comments]</sentence> > 4806c5350,5352 < Tolerance to <cons sem="G#lipid">lipopolysaccharide</cons> involves mobilization of <cons sem="G#protein_molecule">nuclear factor kappa B</cons> with predominance of <cons sem="G#protein_subunit">p50</cons> homodimers. --- > > <sentence>Tolerance to <cons sem="G#lipid">lipopolysaccharide</cons> involves mobilization of <cons sem="G#protein_molecule">nuclear factor kappa B</cons> with predominance of <cons sem="G#protein_subunit">p50</cons> homodimers.</sentence> > 4825c5371,5373 < Analysis of <cons sem="G#other_name"><cons sem="G#protein_family_or_group">Oct2-isoform</cons> expression</cons> in <cons sem="G#cell_line"><cons sem="G#lipid">lipopolysaccharide</cons>-stimulated B lymphocytes</cons>. --- > > <sentence>Analysis of <cons sem="G#other_name"><cons sem="G#protein_family_or_group">Oct2-isoform</cons> expression</cons> in <cons sem="G#cell_line"><cons sem="G#lipid">lipopolysaccharide</cons>-stimulated B lymphocytes</cons>.</sentence> > 4842c5390,5392 < Positive regulators of the lineage-specific <cons sem="G#protein_family_or_group">transcription factor</cons> <cons sem="G#protein_molecule">GATA-1</cons> in <cons sem="G#cell_type">differentiating erythroid cells</cons>. --- > > <sentence>Positive regulators of the lineage-specific <cons sem="G#protein_family_or_group">transcription factor</cons> <cons sem="G#protein_molecule">GATA-1</cons> in <cons sem="G#cell_type">differentiating erythroid cells</cons>.</sentence> > 4846c5396 < Analyses with cultured cells and cell-free systems have provided strong evidence that GATA-1 is involved in control of globin gene expression during erythroid differentiation. --- > Analyses with cultured cells and cell-free systems have provided strong evidence that GATA-1 is involved in control of globin gene expression during erythroid differentiation. 4851c5401 < Nuclei from GATA-1- mutant embryonic stem cells can still be reprogrammed to express their globin genes in erythroid heterokaryons, indicating that de novo induction of GATA-1 is not required for globin gene activation following cell fusion. --- > Nuclei from GATA-1- mutant embryonic stem cells can still be reprogrammed to express their globin genes in erythroid heterokaryons, indicating that de novo induction of GATA-1 is not required for globin gene activation following cell fusion. 4859c5409,5411 < Role of <cons sem="G#protein_molecule"><cons sem="G#virus">HIV-1</cons> Nef</cons> expression in <cons sem="G#other_name">activation pathways</cons> in <cons sem="G#protein_molecule">CD4</cons>+ T cells. --- > > <sentence>Role of <cons sem="G#protein_molecule"><cons sem="G#virus">HIV-1</cons> Nef</cons> expression in <cons sem="G#other_name">activation pathways</cons> in <cons sem="G#protein_molecule">CD4</cons>+ T cells.</sentence> > 4874c5426,5428 < <cons sem="G#protein_molecule">Tat-binding protein 7</cons> is a subunit of the <cons sem="G#protein_complex">26S protease</cons>. --- > > <sentence><cons sem="G#protein_molecule">Tat-binding protein 7</cons> is a subunit of the <cons sem="G#protein_complex">26S protease</cons>.</sentence> > 4887c5441,5443 < <cons sem="G#other_name">Hypoxia</cons> causes the activation of <cons sem="G#protein_molecule">nuclear factor kappa B</cons> through the phosphorylation of <cons sem="G#protein_molecule">I kappa B alpha</cons> on <cons sem="G#amino_acid_monomer"><cons sem="G#amino_acid_monomer">tyrosine</cons> residues</cons>. --- > > <sentence><cons sem="G#other_name">Hypoxia</cons> causes the activation of <cons sem="G#protein_molecule">nuclear factor kappa B</cons> through the phosphorylation of <cons sem="G#protein_molecule">I kappa B alpha</cons> on <cons sem="G#amino_acid_monomer"><cons sem="G#amino_acid_monomer">tyrosine</cons> residues</cons>.</sentence> > 4903c5459,5461 < Overproduction of <cons sem="G#protein_molecule">NFKB2</cons> (<cons sem="G#protein_molecule">lyt-10</cons>) and <cons sem="G#protein_subunit">c-Rel</cons>: a mechanism for <cons sem="G#other_name"><cons sem="G#protein_molecule">HTLV-I Tax</cons>- mediated trans-activation</cons> via the <cons sem="G#other_name"><cons sem="G#protein_molecule">NF-kappa B</cons> signalling pathway</cons>. --- > > <sentence>Overproduction of <cons sem="G#protein_molecule">NFKB2</cons> (<cons sem="G#protein_molecule">lyt-10</cons>) and <cons sem="G#protein_subunit">c-Rel</cons>: a mechanism for <cons sem="G#other_name"><cons sem="G#protein_molecule">HTLV-I Tax</cons>- mediated trans-activation</cons> via the <cons sem="G#other_name"><cons sem="G#protein_molecule">NF-kappa B</cons> signalling pathway</cons>.</sentence> > 4911c5469 < We propose that NFKB2 synthesis and processing allows continuous nuclear expression of an otherwise cytoplasmic protein and, in conjunction with overexpression of c-Rel, NFKB2 alters the NF-kappa B signalling pathway and contributes to leukemic transformation of T cells by HTLV-I --- > We propose that NFKB2 synthesis and processing allows continuous nuclear expression of an otherwise cytoplasmic protein and, in conjunction with overexpression of c-Rel, NFKB2 alters the NF-kappa B signalling pathway and contributes to leukemic transformation of T cells by HTLV-I 4919c5477,5479 < Retinoic acid downmodulates erythroid differentiation and <cons sem="G#other_name">GATA1 expression</cons> in <cons sem="G#cell_line">purified adult-progenitor culture</cons>. --- > > <sentence>Retinoic acid downmodulates erythroid differentiation and <cons sem="G#other_name"><cons sem="G#protein_molecule">GATA1</cons> expression</cons> in <cons sem="G#cell_line">purified adult-progenitor culture</cons>.</sentence> > 4923c5483 < In clonogenetic fetal calf serum-supplemented (FCS+) or -nonsupplemented (FCS-) culture treated with saturating levels of interleukin-3 (IL-3) granulocyte- macrophage colony-stimulating factor (GM-CSF) and erythropoietin (Ep) (combined with c-kit ligand in FCS(-)-culture conditions), RA induces a dramatic dose-dependent shift from erythroid to granulomonocytic colony formation, the latter colonies being essentially represented by granulocytic clones. --- > In clonogenetic fetal calf serum-supplemented (FCS+) or -nonsupplemented (FCS-) culture treated with saturating levels of interleukin-3 (IL-3) granulocyte- macrophage colony-stimulating factor (GM-CSF) and erythropoietin (Ep) (combined with c-kit ligand in FCS(-)-culture conditions), RA induces a dramatic dose-dependent shift from erythroid to granulomonocytic colony formation, the latter colonies being essentially represented by granulocytic clones. 4937c5497,5499 < Induction of <cons sem="G#other_name"><cons sem="G#lipid">phosphatidylinositol</cons> turnover</cons> and <cons sem="G#other_name"><cons sem="G#RNA_molecule">EGR-1 mRNA</cons> expression</cons> by crosslinking of surface <cons sem="G#protein_family_or_group">IgM</cons> and <cons sem="G#protein_family_or_group">IgD</cons> in the <cons sem="G#cell_line">human B cell line B104</cons>. --- > > <sentence>Induction of <cons sem="G#other_name"><cons sem="G#lipid">phosphatidylinositol</cons> turnover</cons> and <cons sem="G#other_name"><cons sem="G#RNA_molecule">EGR-1 mRNA</cons> expression</cons> by crosslinking of surface <cons sem="G#protein_family_or_group">IgM</cons> and <cons sem="G#protein_family_or_group">IgD</cons> in the <cons sem="G#cell_line">human B cell line B104</cons>.</sentence> > 4939c5501 < We have previously shown that a human B lymphoma cell line, B104, expressed surface IgM (sIgM) and surface IgD (sIgD), and that crosslinking of sIgM and sIgD by anti-IgM antibody (Ab) and anti-IgD Ab, respectively, induced Ca2+ influx to almost the same degree, whereas only sIgM-crosslinking caused B104 cell death. --- > We have previously shown that a human B lymphoma cell line, B104, expressed surface IgM (sIgM) and surface IgD (sIgD), and that crosslinking of sIgM and sIgD by anti-IgM antibody (Ab) and anti-IgD Ab, respectively, induced Ca2+ influx to almost the same degree, whereas only sIgM-crosslinking caused B104 cell death. 4955c5517,5519 < Direct exposure to <cons sem="G#other_organic_compound">2,3,7,8-tetrachlorodibenzo-p-dioxin</cons> (<cons sem="G#other_organic_compound">TCDD</cons>) increases infectivity of <cons sem="G#cell_type">human erythrocytes</cons> to a <cons sem="G#mono_cell">malarial parasite</cons>. --- > > <sentence>Direct exposure to <cons sem="G#other_organic_compound">2,3,7,8-tetrachlorodibenzo-p-dioxin</cons> (<cons sem="G#other_organic_compound">TCDD</cons>) increases infectivity of <cons sem="G#cell_type">human erythrocytes</cons> to a <cons sem="G#mono_cell">malarial parasite</cons>.</sentence> > 4968c5532,5534 < Evidence for a <cons sem="G#protein_family_or_group">trans-acting activator</cons> function regulating the expression of the <cons sem="G#protein_molecule">human <cons sem="G#protein_molecule">CD5</cons> antigen</cons>. --- > > <sentence>Evidence for a <cons sem="G#protein_family_or_group">trans-acting activator</cons> function regulating the expression of the <cons sem="G#protein_molecule">human <cons sem="G#protein_molecule">CD5</cons> antigen</cons>.</sentence> > 4983c5549,5551 < Induction of the <cons sem="G#DNA_domain_or_region">CD11b gene</cons> during activation of the <cons sem="G#cell_line">monocytic cell line U937</cons> requires a novel <cons sem="G#protein_family_or_group">nuclear factor</cons> <cons sem="G#protein_molecule">MS-2</cons> [published erratum appears in J Immunol 1999 Jul 15;163(2):1091] --- > > <sentence>Induction of the <cons sem="G#DNA_domain_or_region">CD11b gene</cons> during activation of the <cons sem="G#cell_line">monocytic cell line U937</cons> requires a novel <cons sem="G#protein_family_or_group">nuclear factor</cons> <cons sem="G#protein_molecule">MS-2</cons> [published erratum appears in J Immunol 1999 Jul 15;163(2):1091]</sentence> > 5003c5571,5573 < <cons sem="G#other_organic_compound">Acetylsalicylic acid</cons> and <cons sem="G#other_organic_compound">sodium salicylate</cons> inhibit <cons sem="G#other_name"><cons sem="G#lipid">LPS</cons>-induced <cons sem="G#protein_complex">NF-kappa B/c-Rel</cons> nuclear translocation</cons>, and synthesis of <cons sem="G#protein_family_or_group">tissue factor</cons> (<cons sem="G#protein_family_or_group">TF</cons>) and <cons sem="G#protein_molecule">tumor necrosis factor alfa</cons> (<cons sem="G#protein_molecule">TNF-alpha</cons>) in <cons sem="G#cell_type">human monocytes</cons>. --- > > <sentence><cons sem="G#other_organic_compound">Acetylsalicylic acid</cons> and <cons sem="G#other_organic_compound">sodium salicylate</cons> inhibit <cons sem="G#other_name"><cons sem="G#lipid">LPS</cons>-induced <cons sem="G#protein_complex">NF-kappa B/c-Rel</cons> nuclear translocation</cons>, and synthesis of <cons sem="G#protein_family_or_group">tissue factor</cons> (<cons sem="G#protein_family_or_group">TF</cons>) and <cons sem="G#protein_molecule">tumor necrosis factor alfa</cons> (<cons sem="G#protein_molecule">TNF-alpha</cons>) in <cons sem="G#cell_type">human monocytes</cons>.</sentence> > 5006c5576 < Both drugs dose-dependently inhibited LPS-induced TF and TNF- alpha synthesis at the mRNA and the protein level, and reduced PGE2 production. --- > Both drugs dose-dependently inhibited LPS-induced TF and TNF- alpha synthesis at the mRNA and the protein level, and reduced PGE2 production. 5016c5586,5588 < Interferon augments <cons sem="G#protein_molecule">PML</cons> and <cons sem="G#other_name"><cons sem="G#protein_complex">PML/RAR alpha</cons> expression</cons> in normal <cons sem="G#cell_type">myeloid</cons> and <cons sem="G#cell_type">acute promyelocytic cells</cons> and cooperates with <cons sem="G#other_artificial_source">all-trans retinoic acid</cons> to induce maturation of a <cons sem="G#cell_line">retinoid-resistant promyelocytic cell line</cons>. --- > > <sentence>Interferon augments <cons sem="G#protein_molecule">PML</cons> and <cons sem="G#other_name"><cons sem="G#protein_complex">PML/RAR alpha</cons> expression</cons> in normal <cons sem="G#cell_type">myeloid</cons> and <cons sem="G#cell_type">acute promyelocytic cells</cons> and cooperates with <cons sem="G#other_artificial_source">all-trans retinoic acid</cons> to induce maturation of a <cons sem="G#cell_line">retinoid-resistant promyelocytic cell line</cons>.</sentence> > 5031c5603,5605 < Effects of <cons sem="G#other_organic_compound">Ara-C</cons> on <cons sem="G#protein_molecule">neutral sphingomyelinase</cons> and <cons sem="(AND G#protein_family_or_group G#protein_family_or_group)"><cons>mitogen-</cons> and <cons>stress-</cons> <cons>activated protein kinases</cons></cons> in <cons sem="G#cell_line">T-lymphocyte cell lines</cons>. --- > > <sentence>Effects of <cons sem="G#other_organic_compound">Ara-C</cons> on <cons sem="G#protein_molecule">neutral sphingomyelinase</cons> and <cons sem="(AND G#protein_family_or_group G#protein_family_or_group)"><cons>mitogen-</cons> and <cons>stress-</cons> <cons>activated protein kinases</cons></cons> in <cons sem="G#cell_line">T-lymphocyte cell lines</cons>.</sentence> > 5036c5610 < PMA, but not Ara-C or ceramides, activated ERK MAPKS, in Jurkat and EL4. --- > PMA, but not Ara-C or ceramides, activated ERK MAPKS, in Jurkat and EL4. 5039,5040c5613,5614 < Thus, ceramide is not a positive signal for ERK activation in T-cell lines. < The effects of Ara-C on JNK activity may be mediated through secondary response pathways. --- > Thus, ceramide is not a positive signal for ERK activation in T-cell lines. > The effects of Ara-C on JNK activity may be mediated through secondary response pathways. 5048c5622,5624 < Comparative analysis identifies conserved <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule"><cons sem="G#protein_family_or_group">tumor necrosis factor receptor</cons>-associated factor 3</cons> binding sites</cons> in the <cons sem="(AND G#DNA_domain_or_region G#DNA_domain_or_region)"><cons>human</cons> and <cons>simian</cons> <cons><cons sem="G#virus">Epstein-Barr virus</cons> <cons sem="G#DNA_domain_or_region">oncogene LMP1</cons></cons></cons>. --- > > <sentence>Comparative analysis identifies conserved <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule"><cons sem="G#protein_family_or_group">tumor necrosis factor receptor</cons>-associated factor 3</cons> binding sites</cons> in the <cons sem="(AND G#DNA_domain_or_region G#DNA_domain_or_region)"><cons>human</cons> and <cons>simian</cons> <cons><cons sem="G#virus">Epstein-Barr virus</cons> <cons sem="G#DNA_domain_or_region">oncogene LMP1</cons></cons></cons>.</sentence> > 5055,5056c5631,5632 < Nevertheless, the simian EBV LMP1s retain most functions in common with EBV LMP1, including the ability to induce NF- (kappa)B activity in human cells, to bind the tumor necrosis factor- associated factor 3 (TRAF3) in vitro, and to induce expression of tumor necrosis factor-responsive genes, such as ICAM1, in human B lymphocytes. < Multiple TRAF3 binding sites containing a PXQXT/S core sequence can be identified in the simian EBV LMP1s by an in vitro binding assay. --- > Nevertheless, the simian EBV LMP1s retain most functions in common with EBV LMP1, including the ability to induce NF- (kappa)B activity in human cells, to bind the tumor necrosis factor- associated factor 3 (TRAF3) in vitro, and to induce expression of tumor necrosis factor-responsive genes, such as ICAM1, in human B lymphocytes. > Multiple TRAF3 binding sites containing a PXQXT/S core sequence can be identified in the simian EBV LMP1s by an in vitro binding assay. 5067c5643,5645 < <cons sem="G#other_name"><cons sem="G#DNA_molecule">Chromosome 1</cons> aneusomy</cons> with <cons sem="G#other_name">1p36 under-representation</cons> is related to histologic grade, <cons sem="G#other_name">DNA aneuploidy</cons>, high <cons sem="G#protein_molecule">c-erb B-2</cons> and loss of <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">bcl-2</cons> expression</cons> in <cons sem="G#other_name">ductal breast carcinoma</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#DNA_molecule">Chromosome 1</cons> aneusomy</cons> with <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">1p36</cons> under-representation</cons> is related to histologic grade, <cons sem="G#other_name">DNA aneuploidy</cons>, high <cons sem="G#protein_molecule">c-erb B-2</cons> and loss of <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">bcl-2</cons> expression</cons> in <cons sem="G#other_name">ductal breast carcinoma</cons>.</sentence> > 5086,5087c5664,5667 < <cons sem="G#other_organic_compound">G(Anh)MTetra</cons>, a natural <cons sem="G#other_organic_compound">bacterial cell wall breakdown product</cons>, induces <cons sem="G#protein_molecule">interleukin-1 beta</cons> and <cons sem="G#other_name"><cons sem="G#protein_molecule">interleukin-6</cons> expression</cons> in <cons sem="G#cell_type">human monocytes</cons>. < A study of the <cons sem="G#other_name">molecular mechanisms</cons> involved in <cons sem="G#other_name"><cons sem="G#protein_family_or_group">inflammatory cytokine</cons> expression</cons> [published erratum appears in J Biol Chem 1994 Jun 17;269(24):16983] --- > > <sentence><cons sem="G#other_organic_compound">G(Anh)MTetra</cons>, a natural <cons sem="G#other_organic_compound">bacterial cell wall breakdown product</cons>, induces <cons sem="G#protein_molecule">interleukin-1 beta</cons> and <cons sem="G#other_name"><cons sem="G#protein_molecule">interleukin-6</cons> expression</cons> in <cons sem="G#cell_type">human monocytes</cons>.</sentence> > <sentence>A study of the <cons sem="G#other_name">molecular mechanisms</cons> involved in <cons sem="G#other_name"><cons sem="G#protein_family_or_group">inflammatory cytokine</cons> expression</cons> [published erratum appears in J Biol Chem 1994 Jun 17;269(24):16983]</sentence> > 5106c5686,5688 < Increased <cons sem="G#other_name">proliferation</cons>, <cons sem="G#other_name">cytotoxicity</cons>, and <cons sem="G#other_name">gene expression</cons> after stimulation of <cons sem="G#cell_type">human peripheral blood T lymphocytes</cons> through a <cons sem="G#lipid">surface ganglioside</cons> (<cons sem="G#lipid">GD3</cons>) [published erratum appears in J Immunol 1994 Jul 15;153(2):910] --- > > <sentence>Increased <cons sem="G#other_name">proliferation</cons>, <cons sem="G#other_name">cytotoxicity</cons>, and <cons sem="G#other_name">gene expression</cons> after stimulation of <cons sem="G#cell_type">human peripheral blood T lymphocytes</cons> through a <cons sem="G#lipid">surface ganglioside</cons> (<cons sem="G#lipid">GD3</cons>) [published erratum appears in J Immunol 1994 Jul 15;153(2):910]</sentence> > 5127c5709,5711 < Genes encoding <cons sem="G#protein_family_or_group">general initiation factors</cons> for <cons sem="G#other_name">RNA polymerase II transcription</cons> are dispersed in the <cons sem="G#DNA_family_or_group">human genome</cons>. --- > > <sentence>Genes encoding <cons sem="G#protein_family_or_group">general initiation factors</cons> for <cons sem="G#other_name"><cons sem="G#protein_molecule">RNA polymerase II</cons> transcription</cons> are dispersed in the <cons sem="G#DNA_family_or_group">human genome</cons>.</sentence> > 5140c5724,5726 < <cons sem="G#protein_molecule">BCL-6</cons> and the <cons sem="G#other_name">molecular pathogenesis</cons> of <cons sem="G#other_name">B-cell lymphoma</cons>. --- > > <sentence><cons sem="G#protein_molecule">BCL-6</cons> and the <cons sem="G#other_name">molecular pathogenesis</cons> of <cons sem="G#other_name">B-cell lymphoma</cons>.</sentence> > 5157,5158c5743,5746 < Pancreatic development and maturation of the <cons sem="G#cell_type">islet B cell</cons>. < Studies of <cons sem="G#cell_line">pluripotent islet cultures</cons>. --- > > <sentence>Pancreatic development and maturation of the <cons sem="G#cell_type">islet B cell</cons>.</sentence> > <sentence>Studies of <cons sem="G#cell_line">pluripotent islet cultures</cons>.</sentence> > 5174c5762,5764 < <cons sem="G#other_name">Octamer independent activation</cons> of <cons sem="G#other_name">transcription</cons> from the <cons sem="G#DNA_domain_or_region">kappa immunoglobulin germline promoter</cons>. --- > > <sentence><cons sem="G#other_name">Octamer independent activation</cons> of <cons sem="G#other_name">transcription</cons> from the <cons sem="G#DNA_domain_or_region">kappa immunoglobulin germline promoter</cons>.</sentence> > 5178c5768 < To further elucidate the role of this variant octamer motif in the regulation of germline transcription from the unrearranged kappa locus, we have quantitated the relative binding affinity of Oct-1 and Oct-2 for the variant octamer motif and determined the functional role of this octamer motif in transcriptional activation. --- > To further elucidate the role of this variant octamer motif in the regulation of germline transcription from the unrearranged kappa locus, we have quantitated the relative binding affinity of Oct-1 and Oct-2 for the variant octamer motif and determined the functional role of this octamer motif in transcriptional activation. 5182c5772 < These findings have important implications in regulation of germline transcription as well as concomitant activation of the V-J recombination of the kappa light chain locus. --- > These findings have important implications in regulation of germline transcription as well as concomitant activation of the V-J recombination of the kappa light chain locus. 5190c5780,5782 < Generation of <cons sem="G#cell_type">CD1+RelB+ dendritic cells</cons> and <cons sem="G#cell_type">tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells</cons> from <cons sem="G#cell_type">human monocytes</cons>. --- > > <sentence>Generation of <cons sem="G#cell_type">CD1+RelB+ dendritic cells</cons> and <cons sem="G#cell_type">tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells</cons> from <cons sem="G#cell_type">human monocytes</cons>.</sentence> > 5201c5793 < Such a diverse pathway of monocyte differentiation may constitute one of the basic mechanisms of immune regulation. --- > Such a diverse pathway of monocyte differentiation may constitute one of the basic mechanisms of immune regulation. 5209c5801,5803 < The <cons sem="G#other_organic_compound"><cons sem="G#protein_complex">NF-kappa B</cons> inhibitor</cons>, tepoxalin, suppresses surface expression of the <cons sem="G#protein_family_or_group">cell adhesion molecules</cons> <cons sem="G#protein_molecule">CD62E</cons>, <cons sem="G#protein_molecule">CD11b/CD18</cons> and <cons sem="G#protein_molecule">CD106</cons>. --- > > <sentence>The <cons sem="G#other_organic_compound"><cons sem="G#protein_complex">NF-kappa B</cons> inhibitor</cons>, tepoxalin, suppresses surface expression of the <cons sem="G#protein_family_or_group">cell adhesion molecules</cons> <cons sem="G#protein_molecule">CD62E</cons>, <cons sem="G#protein_molecule">CD11b/CD18</cons> and <cons sem="G#protein_molecule">CD106</cons>.</sentence> > 5227c5821,5823 < Characterization of a <cons sem="G#other_name">CD43/leukosialin-mediated pathway</cons> for inducing <cons sem="G#other_name">apoptosis</cons> in <cons sem="G#cell_type">human T-lymphoblastoid cells</cons>. --- > > <sentence>Characterization of a <cons sem="G#other_name"><cons sem="G#protein_molecule">CD43/leukosialin</cons>-mediated pathway</cons> for inducing <cons sem="G#other_name">apoptosis</cons> in <cons sem="G#cell_type">human T-lymphoblastoid cells</cons>.</sentence> > 5230c5826 < NH2-terminal amino acid sequence analysis identified the 140-kDa surface antigen for mAb J393 as CD43/leukosialin, the major sialoglycoprotein of leukocytes. --- > NH2-terminal amino acid sequence analysis identified the 140-kDa surface antigen for mAb J393 as CD43/leukosialin, the major sialoglycoprotein of leukocytes. 5234c5830 < Treatment of Jurkat cells with mAb J393 induced tyrosine phosphorylation of specific protein substrates that underwent hyperphosphorylation upon antigen receptor costimulation. --- > Treatment of Jurkat cells with mAb J393 induced tyrosine phosphorylation of specific protein substrates that underwent hyperphosphorylation upon antigen receptor costimulation. 5245c5841,5843 < <cons sem="G#other_name">Sterol dependent <cons sem="G#DNA_domain_or_region">LDL-receptor gene</cons> transcription</cons> in <cons sem="G#cell_type">lymphocytes</cons> from normal and <cons sem="G#multi_cell">CML <cons sem="G#multi_cell">patients</cons></cons>. --- > > <sentence><cons sem="G#other_name">Sterol dependent <cons sem="G#DNA_domain_or_region">LDL-receptor gene</cons> transcription</cons> in <cons sem="G#cell_type">lymphocytes</cons> from normal and <cons sem="G#multi_cell">CML <cons sem="G#multi_cell">patients</cons></cons>.</sentence> > 5250c5848 < However, this factor appeared when the CML patients achieved complete haematological remission (CHR) through alpha-interferon therapy. --- > However, this factor appeared when the CML patients achieved complete haematological remission (CHR) through alpha-interferon therapy. 5260c5858,5860 < Multiple <cons sem="G#DNA_family_or_group">prolactin-responsive elements</cons> mediate <cons sem="(AND G#other_name G#other_name)"><cons>G1</cons> and <cons>S</cons> <cons>phase expression</cons></cons> of the <cons sem="G#DNA_domain_or_region">interferon regulatory factor-1 gene</cons>. --- > > <sentence>Multiple <cons sem="G#DNA_family_or_group">prolactin-responsive elements</cons> mediate <cons sem="(AND G#other_name G#other_name)"><cons>G1</cons> and <cons>S</cons> <cons>phase expression</cons></cons> of the <cons sem="G#DNA_domain_or_region">interferon regulatory factor-1 gene</cons>.</sentence> > 5278c5878,5880 < Regulation of the <cons sem="G#DNA_domain_or_region">BZLF1 promoter</cons> of <cons sem="G#virus">Epstein-Barr virus</cons> by <cons sem="G#other_organic_compound">second messengers</cons> in <cons sem="G#cell_line">anti-immunoglobulin-treated B cells</cons>. --- > > <sentence>Regulation of the <cons sem="G#DNA_domain_or_region">BZLF1 promoter</cons> of <cons sem="G#virus">Epstein-Barr virus</cons> by <cons sem="G#other_organic_compound">second messengers</cons> in <cons sem="G#cell_line">anti-immunoglobulin-treated B cells</cons>.</sentence> > 5286c5888 < 1-(5-Isoquinolinyl sulfonyl)-2- methylpiperazine, an inhibitor of PKC, inhibited the anti-Ig inducibility of Zp. --- > 1-(5-Isoquinolinyl sulfonyl)-2- methylpiperazine, an inhibitor of PKC, inhibited the anti-Ig inducibility of Zp. 5298c5900,5902 < The <cons sem="G#protein_molecule">SCL protein</cons> displays <cons sem="G#other_name">cell-specific heterogeneity</cons> in size. --- > > <sentence>The <cons sem="G#protein_molecule">SCL protein</cons> displays <cons sem="G#other_name">cell-specific heterogeneity</cons> in size.</sentence> > 5304c5908 < Overexpression of full-length SCL protein in the lymphoid cell lines, SupT1 and Raji, did not alter cell phenotype and there was no evidence for autoregulation of SCL transcription. --- > Overexpression of full-length SCL protein in the lymphoid cell lines, SupT1 and Raji, did not alter cell phenotype and there was no evidence for autoregulation of SCL transcription. 5314c5918,5920 < Description and functional implications of a <cons sem="G#other_name">novel mutation</cons> in the <cons sem="G#DNA_family_or_group">sex- determining gene</cons> <cons sem="G#DNA_domain_or_region">SRY</cons>. --- > > <sentence>Description and functional implications of a <cons sem="G#other_name">novel mutation</cons> in the <cons sem="G#DNA_family_or_group">sex- determining gene</cons> <cons sem="G#DNA_domain_or_region">SRY</cons>.</sentence> > 5328c5934,5936 < Induction of <cons sem="G#other_name"><cons sem="G#amino_acid_monomer">tyrosine</cons> phosphorylation</cons> and <cons sem="G#other_name"><cons sem="G#cell_type">T-cell</cons> activation</cons> by <cons sem="G#other_organic_compound">vanadate peroxide</cons>, an inhibitor of <cons sem="G#protein_family_or_group">protein <cons sem="G#amino_acid_monomer">tyrosine</cons> phosphatases</cons>. --- > > <sentence>Induction of <cons sem="G#other_name"><cons sem="G#amino_acid_monomer">tyrosine</cons> phosphorylation</cons> and <cons sem="G#other_name"><cons sem="G#cell_type">T-cell</cons> activation</cons> by <cons sem="G#other_organic_compound">vanadate peroxide</cons>, an inhibitor of <cons sem="G#protein_family_or_group">protein <cons sem="G#amino_acid_monomer">tyrosine</cons> phosphatases</cons>.</sentence> > 5337c5945 < Pervanadate synergized with signals delivered by T-cell antigen receptor engagement or by a phorbol ester to induce interleukin 2 production. --- > Pervanadate synergized with signals delivered by T-cell antigen receptor engagement or by a phorbol ester to induce interleukin 2 production. 5348,5349c5956,5959 < Activation of <cons sem="G#protein_molecule">nuclear factor-kappaB</cons> via <cons sem="G#protein_family_or_group">T cell receptor</cons> requires a <cons sem="G#protein_family_or_group">Raf kinase</cons> and <cons sem="G#atom">Ca2+</cons> influx. < Functional synergy between <cons sem="G#protein_family_or_group">Raf</cons> and <cons sem="G#protein_molecule">calcineurin</cons>. --- > > <sentence>Activation of <cons sem="G#protein_molecule">nuclear factor-kappaB</cons> via <cons sem="G#protein_family_or_group">T cell receptor</cons> requires a <cons sem="G#protein_family_or_group">Raf kinase</cons> and <cons sem="G#atom">Ca2+</cons> influx.</sentence> > <sentence>Functional synergy between <cons sem="G#protein_family_or_group">Raf</cons> and <cons sem="G#protein_molecule">calcineurin</cons>.</sentence> > 5351c5961 < Signals transduced via the TCR activate the transcription factor nuclear factor-kappaB (NF-kappaB), which, in turn, is critical to the transcriptional induction of many genes important for the proliferation and expression of a differentiated phenotype. --- > Signals transduced via the TCR activate the transcription factor nuclear factor-kappaB (NF-kappaB), which, in turn, is critical to the transcriptional induction of many genes important for the proliferation and expression of a differentiated phenotype. 5354c5964 < TCR signaling was triggered by treating Jurkat T cells with PHA or anti-CD3 Abs, and NF-kappaB activation was monitored by electrophoretic mobility shift assays and/or by kappaB-dependent reporter assays. --- > TCR signaling was triggered by treating Jurkat T cells with PHA or anti-CD3 Abs, and NF-kappaB activation was monitored by electrophoretic mobility shift assays and/or by kappaB-dependent reporter assays. 5359c5969 < Consistent with these observations, coexpression of constitutively active forms of Raf-1 and calcineurin synergistically induced kappaB-dependent reporter activity, suggesting a physiologically relevant functional interaction between the kinase and the phosphatase. --- > Consistent with these observations, coexpression of constitutively active forms of Raf-1 and calcineurin synergistically induced kappaB-dependent reporter activity, suggesting a physiologically relevant functional interaction between the kinase and the phosphatase. 5367c5977,5979 < Synergistic interactions between <cons sem="G#DNA_family_or_group">overlapping binding sites</cons> for the <cons sem="G#protein_family_or_group">serum response factor</cons> and <cons sem="G#protein_molecule">ELK-1 proteins</cons> mediate both basal enhancement and <cons sem="G#other_organic_compound">phorbol ester</cons> responsiveness of <cons sem="G#DNA_domain_or_region"><cons sem="G#virus">primate cytomegaloviru</cons>s major immediate-early promoters</cons> in monocyte and <cons sem="G#cell_type">T-lymphocyte</cons> cell types. --- > > <sentence>Synergistic interactions between <cons sem="G#DNA_family_or_group">overlapping binding sites</cons> for the <cons sem="G#protein_family_or_group">serum response factor</cons> and <cons sem="G#protein_molecule">ELK-1 proteins</cons> mediate both basal enhancement and <cons sem="G#other_organic_compound">phorbol ester</cons> responsiveness of <cons sem="G#DNA_domain_or_region"><cons sem="G#virus">primate cytomegalovirus</cons> major immediate-early promoters</cons> in monocyte and <cons sem="G#cell_type">T-lymphocyte</cons> cell types.</sentence> > 5386c5998,6000 < <cons sem="G#other_name"><cons sem="G#cell_type">T-cell</cons>-directed TAL-1 expression</cons> induces <cons sem="G#other_name">T-cell malignancies</cons> in <cons sem="G#multi_cell">transgenic mice</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#cell_type">T-cell</cons>-directed <cons sem="G#protein_molecule">TAL-1</cons> expression</cons> induces <cons sem="G#other_name">T-cell malignancies</cons> in <cons sem="G#multi_cell">transgenic mice</cons>.</sentence> > 5404c6018,6020 < Tissue and cell-type specific expression of the <cons sem="G#DNA_domain_or_region">tuberous sclerosis gene</cons>, <cons sem="G#DNA_domain_or_region">TSC2</cons>, in <cons sem="G#tissue">human tissues</cons>. --- > > <sentence>Tissue and cell-type specific expression of the <cons sem="G#DNA_domain_or_region">tuberous sclerosis gene</cons>, <cons sem="G#DNA_domain_or_region">TSC2</cons>, in <cons sem="G#tissue">human tissues</cons>.</sentence> > 5419c6035,6037 < <cons sem="G#other_name">Apoptosis signaling pathways</cons> in normal <cons sem="G#cell_type">T cells</cons>: differential activity of <cons sem="G#protein_molecule">Bcl-2</cons> and <cons sem="G#other_organic_compound"><cons sem="G#protein_family_or_group"><cons sem="G#protein_molecule">IL-1beta</cons>-converting enzyme family</cons> protease inhibitors</cons> on <cons sem="(AND G#other_name G#other_name)"><cons>glucocorticoid-</cons> and <cons>Fas-</cons><cons>mediated cytotoxicity</cons></cons>. --- > > <sentence><cons sem="G#other_name">Apoptosis signaling pathways</cons> in normal <cons sem="G#cell_type">T cells</cons>: differential activity of <cons sem="G#protein_molecule">Bcl-2</cons> and <cons sem="G#other_organic_compound"><cons sem="G#protein_family_or_group"><cons sem="G#protein_molecule">IL-1beta</cons>-converting enzyme family</cons> protease inhibitors</cons> on <cons sem="(AND G#other_name G#other_name)"><cons>glucocorticoid-</cons> and <cons>Fas-</cons><cons>mediated cytotoxicity</cons></cons>.</sentence> > 5421c6039 < Fas-mediated apoptosis plays an important role in regulating the immune response in peripheral T cells. --- > Fas-mediated apoptosis plays an important role in regulating the immune response in peripheral T cells. 5437c6055,6057 < Increased <cons sem="G#other_name">interleukin 2 transcription</cons> in <cons sem="G#cell_type">murine lymphocytes</cons> by <cons sem="G#other_organic_compound">ciprofloxacin</cons>. --- > > <sentence>Increased <cons sem="G#other_name"><cons sem="G#protein_molecule">interleukin 2</cons> transcription</cons> in <cons sem="G#cell_type">murine lymphocytes</cons> by <cons sem="G#other_organic_compound">ciprofloxacin</cons>.</sentence> > 5440c6060 < In this investigation an enhanced and prolonged IL-2 and IL-2 mRNA response was also detected in both stimulated (T cell mitogens or alloantigens) murine splenocytes and in the stimulated murine T cell line EL-4 in the presence of ciprofloxacin (5-80 micrograms/ml) as compared to control cells without antibiotics. --- > In this investigation an enhanced and prolonged IL-2 and IL-2 mRNA response was also detected in both stimulated (T cell mitogens or alloantigens) murine splenocytes and in the stimulated murine T cell line EL-4 in the presence of ciprofloxacin (5-80 micrograms/ml) as compared to control cells without antibiotics. 5454c6074,6076 < Human <cons sem="G#virus">T-cell leukemia virus type I</cons> <cons sem="G#protein_molecule">Tax</cons> associates with and is negatively regulated by the <cons sem="G#protein_molecule"><cons sem="G#DNA_domain_or_region">NF-kappa B2 p100 gene</cons> product</cons>: implications for viral latency. --- > > <sentence>Human <cons sem="G#virus">T-cell leukemia virus type I</cons> <cons sem="G#protein_molecule">Tax</cons> associates with and is negatively regulated by the <cons sem="G#protein_molecule"><cons sem="G#DNA_domain_or_region">NF-kappa B2 p100 gene</cons> product</cons>: implications for viral latency.</sentence> > 5462c6084 < Furthermore, the physical interaction of Tax with p100 leads to the inhibition of Tax-induced activation of the HTLV-I and human immunodeficiency virus type 1 long terminal repeats, reflecting p100- mediated cytoplasmic sequestration of the normally nuclearly expressed Tax protein. --- > Furthermore, the physical interaction of Tax with p100 leads to the inhibition of Tax-induced activation of the HTLV-I and human immunodeficiency virus type 1 long terminal repeats, reflecting p100- mediated cytoplasmic sequestration of the normally nuclearly expressed Tax protein. 5472c6094,6096 < Rhabdomyosarcomas do not contain mutations in the DNA binding domains of myogenic <cons sem="G#protein_family_or_group">transcription factors</cons>. --- > > <sentence>Rhabdomyosarcomas do not contain mutations in the DNA binding domains of myogenic <cons sem="G#protein_family_or_group">transcription factors</cons>.</sentence> > 5475c6099 < We have previously shown that after a mutation of Leu122 to Arg the DNA binding basic domain of MyoD confers c-myc-like functional characteristics to the protein. --- > We have previously shown that after a mutation of Leu122 to Arg the DNA binding basic domain of MyoD confers c-myc-like functional characteristics to the protein. 5486c6110,6112 < Function and activation of <cons sem="G#protein_molecule">NF-kappa B</cons> in the <cons sem="G#other_name">immune system</cons>. --- > > <sentence>Function and activation of <cons sem="G#protein_molecule">NF-kappa B</cons> in the <cons sem="G#other_name">immune system</cons>.</sentence> > 5507c6133,6135 < Lack of <cons sem="G#other_name">T-cell-mediated recognition</cons> of the fusion region of the <cons sem="G#protein_molecule">pml/RAR- alpha hybrid protein</cons> by <cons sem="G#cell_type">lymphocytes</cons> of acute <cons sem="G#other_name">promyelocytic leukemia patients</cons>. --- > > <sentence>Lack of <cons sem="G#other_name">T-cell-mediated recognition</cons> of the fusion region of the <cons sem="G#protein_molecule">pml/RAR- alpha hybrid protein</cons> by <cons sem="G#cell_type">lymphocytes</cons> of acute <cons sem="G#other_name">promyelocytic leukemia patients</cons>.</sentence> > 5509c6137 < In previous studies, it was shown that the fusion region of the pml/RAR- alpha protein, expressed by acute promyelocytic leukemia (APL) cells, can be specifically recognized in vitro by donor (D. E.) CD4 T cells in a HLA class II DR11-restricted fashion. --- > In previous studies, it was shown that the fusion region of the pml/RAR- alpha protein, expressed by acute promyelocytic leukemia (APL) cells, can be specifically recognized in vitro by donor (D. E.) CD4 T cells in a HLA class II DR11-restricted fashion. 5519c6147 < Since APL cells do not express HLA class II molecules, we tested in two donors (D.E. and C.H.R.) and in patients S.R.and P.G.whether the use of 9-mer peptides (BCR1/9) would generate a CD8/HLA class I-restricted response. --- > Since APL cells do not express HLA class II molecules, we tested in two donors (D.E. and C.H.R.) and in patients S.R.and P.G.whether the use of 9-mer peptides (BCR1/9) would generate a CD8/HLA class I-restricted response. 5529c6157,6159 < The proximal regulatory element of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">interferon-gamma</cons> promoter</cons> mediates selective expression in <cons sem="G#cell_type">T cells</cons>. --- > > <sentence>The proximal regulatory element of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">interferon-gamma</cons> promoter</cons> mediates selective expression in <cons sem="G#cell_type">T cells</cons>.</sentence> > 5546c6176,6178 < <cons sem="G#protein_molecule">CD40</cons>, but not <cons sem="G#lipid">lipopolysaccharide</cons> and <cons sem="G#other_name">anti-IgM stimulation</cons> of <cons sem="G#cell_type">primary B lymphocytes</cons>, leads to a persistent nuclear accumulation of <cons sem="G#protein_molecule">RelB</cons>. --- > > <sentence><cons sem="G#protein_molecule">CD40</cons>, but not <cons sem="G#lipid">lipopolysaccharide</cons> and <cons sem="G#other_name"><cons sem="G#protein_family_or_group">anti-IgM</cons> stimulation</cons> of <cons sem="G#cell_type">primary B lymphocytes</cons>, leads to a persistent nuclear accumulation of <cons sem="G#protein_molecule">RelB</cons>.</sentence> > 5564c6196,6198 < Identification and characterization of a <cons sem="G#cell_component">leukocyte-specific component</cons> of the <cons sem="G#cell_component">nuclear body</cons>. --- > > <sentence>Identification and characterization of a <cons sem="G#cell_component">leukocyte-specific component</cons> of the <cons sem="G#cell_component">nuclear body</cons>.</sentence> > 5569c6203 < The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100, a previously identified NB protein. --- > The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100, a previously identified NB protein. 5582c6216,6218 < Regulation of <cons sem="G#protein_family_or_group">cytokine</cons> and <cons sem="G#other_name"><cons sem="G#protein_family_or_group"><cons sem="G#protein_family_or_group">cytokine</cons> receptor</cons> expression</cons> by <cons sem="G#lipid">glucocorticoids</cons>. --- > > <sentence>Regulation of <cons sem="G#protein_family_or_group">cytokine</cons> and <cons sem="G#other_name"><cons sem="G#protein_family_or_group"><cons sem="G#protein_family_or_group">cytokine</cons> receptor</cons> expression</cons> by <cons sem="G#lipid">glucocorticoids</cons>.</sentence> > 5596c6232,6234 < Isolation and characterization of <cons sem="G#DNA_domain_or_region">murine fra-1</cons>: induction mediated by <cons sem="G#protein_molecule">CD40</cons> and <cons sem="G#protein_family_or_group">surface Ig</cons> is <cons sem="G#other_name"><cons sem="G#protein_molecule">protein kinase C</cons> dependent</cons>. --- > > <sentence>Isolation and characterization of <cons sem="G#DNA_domain_or_region">murine fra-1</cons>: induction mediated by <cons sem="G#protein_molecule">CD40</cons> and <cons sem="G#protein_family_or_group">surface Ig</cons> is <cons sem="G#other_name"><cons sem="G#protein_molecule">protein kinase C</cons> dependent</cons>.</sentence> > 5613c6251,6253 < <cons sem="G#other_organic_compound">Pentoxifylline</cons> for the treatment of infection with <cons sem="G#virus">human immunodeficiency virus</cons>. --- > > <sentence><cons sem="G#other_organic_compound">Pentoxifylline</cons> for the treatment of infection with <cons sem="G#virus">human immunodeficiency virus</cons>.</sentence> > 5627c6267,6269 < Activation of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">granulocyte-macrophage colony-stimulating factor</cons> promoter</cons> in <cons sem="G#cell_type">T cells</cons> requires cooperative binding of <cons sem="G#protein_molecule">Elf-1</cons> and <cons sem="G#protein_molecule">AP-1</cons> <cons sem="G#protein_family_or_group">transcription factors</cons>. --- > > <sentence>Activation of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">granulocyte-macrophage colony-stimulating factor</cons> promoter</cons> in <cons sem="G#cell_type">T cells</cons> requires cooperative binding of <cons sem="G#protein_molecule">Elf-1</cons> and <cons sem="G#protein_molecule">AP-1</cons> <cons sem="G#protein_family_or_group">transcription factors</cons>.</sentence> > 5645,5646c6287,6290 < <cons sem="G#other_name">Steroid-resistant asthma</cons>. < <cons sem="G#other_name">Cellular mechanisms</cons> contributing to inadequate response to <cons sem="G#other_name"><cons sem="G#lipid">glucocorticoid</cons> therapy</cons>. --- > > <sentence><cons sem="G#other_name">Steroid-resistant asthma</cons>. > <cons sem="G#other_name">Cellular mechanisms</cons> contributing to inadequate response to <cons sem="G#other_name"><cons sem="G#lipid">glucocorticoid</cons> therapy</cons>.</sentence> > 5665c6309,6311 < Prevalence of <cons sem="G#other_name">aneuploidy</cons>, overexpressed <cons sem="G#protein_family_or_group">ER</cons>, and overexpressed <cons sem="G#protein_family_or_group">EGFR</cons> in random <cons sem="G#tissue">breast aspirates</cons> of <cons sem="G#multi_cell">women</cons> at high and low risk for <cons sem="G#other_name">breast cancer</cons>. --- > > <sentence>Prevalence of <cons sem="G#other_name">aneuploidy</cons>, overexpressed <cons sem="G#protein_family_or_group">ER</cons>, and overexpressed <cons sem="G#protein_family_or_group">EGFR</cons> in random <cons sem="G#tissue">breast aspirates</cons> of <cons sem="G#multi_cell">women</cons> at high and low risk for <cons sem="G#other_name">breast cancer</cons>.</sentence> > 5686c6332,6334 < Inhibition of <cons sem="G#RNA_molecule"><cons sem="G#protein_subunit"><cons sem="G#protein_molecule">nuclear factor kappa B</cons> subunit p65</cons> mRNA</cons> accumulation in <cons sem="G#cell_line"><cons sem="G#lipid">lipopolysaccharide</cons>-stimulated human monocytic cells</cons> treated with <cons sem="G#other_organic_compound">sodium salicylate</cons>. --- > > <sentence>Inhibition of <cons sem="G#RNA_molecule"><cons sem="G#protein_subunit"><cons sem="G#protein_molecule">nuclear factor kappa B</cons> subunit p65</cons> mRNA</cons> accumulation in <cons sem="G#cell_line"><cons sem="G#lipid">lipopolysaccharide</cons>-stimulated human monocytic cells</cons> treated with <cons sem="G#other_organic_compound">sodium salicylate</cons>.</sentence> > 5704c6352,6354 < <cons sem="G#other_name"><cons sem="G#lipid">Glucocorticoid</cons>-mediated inhibition</cons> of <cons sem="G#other_name"><cons sem="G#protein_molecule">RANTES</cons> expression</cons> in <cons sem="G#cell_type">human T lymphocytes</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#lipid">Glucocorticoid</cons>-mediated inhibition</cons> of <cons sem="G#other_name"><cons sem="G#protein_molecule">RANTES</cons> expression</cons> in <cons sem="G#cell_type">human T lymphocytes</cons>.</sentence> > 5717c6367,6369 < Association of <cons sem="G#protein_molecule">TRAF1</cons>, <cons sem="G#protein_molecule">TRAF2</cons>, and <cons sem="G#protein_molecule">TRAF3</cons> with an <cons sem="G#DNA_domain_or_region">Epstein-Barr virus LMP1 domain</cons> important for <cons sem="G#other_name"><cons sem="G#cell_type">B-lymphocyte</cons> transformation</cons>: role in <cons sem="G#other_name"><cons sem="G#protein_molecule">NF-kappaB</cons> activation</cons>. --- > > <sentence>Association of <cons sem="G#protein_molecule">TRAF1</cons>, <cons sem="G#protein_molecule">TRAF2</cons>, and <cons sem="G#protein_molecule">TRAF3</cons> with an <cons sem="G#DNA_domain_or_region">Epstein-Barr virus LMP1 domain</cons> important for <cons sem="G#other_name"><cons sem="G#cell_type">B-lymphocyte</cons> transformation</cons>: role in <cons sem="G#other_name"><cons sem="G#protein_molecule">NF-kappaB</cons> activation</cons>.</sentence> > 5735c6387,6389 < Lack of <cons sem="G#other_name"><cons sem="G#protein_molecule">IL-12</cons> signaling</cons> in <cons sem="G#cell_line">human allergen-specific Th2 cells</cons>. --- > > <sentence>Lack of <cons sem="G#other_name"><cons sem="G#protein_molecule">IL-12</cons> signaling</cons> in <cons sem="G#cell_line">human allergen-specific Th2 cells</cons>.</sentence> > 5737,5738c6391,6392 < IL-12 is a powerful skewer of CD4+ T cell responses toward the Th1 phenotype by inducing IFN-gamma production in naive Th cells. < In the present study we addressed the question of whether IL-12 can reverse established Th2 responses into Th1/Th0 responses by inducing IFN-gamma production in memory Th2 cells. --- > IL-12 is a powerful skewer of CD4+ T cell responses toward the Th1 phenotype by inducing IFN-gamma production in naive Th cells. > In the present study we addressed the question of whether IL-12 can reverse established Th2 responses into Th1/Th0 responses by inducing IFN-gamma production in memory Th2 cells. 5754c6408,6410 < Cloning and expression of the <cons sem="G#protein_molecule"><cons sem="G#virus">Epstein-Barr virus</cons>-encoded dUTPase</cons>: <cons sem="G#multi_cell">patients</cons> with acute, reactivated or chronic <cons sem="G#other_name">virus infection</cons> develop <cons sem="G#protein_family_or_group">antibodies</cons> against the <cons sem="G#protein_family_or_group">enzyme</cons>. --- > > <sentence>Cloning and expression of the <cons sem="G#protein_molecule"><cons sem="G#virus">Epstein-Barr virus</cons>-encoded dUTPase</cons>: <cons sem="G#multi_cell">patients</cons> with acute, reactivated or chronic <cons sem="G#other_name">virus infection</cons> develop <cons sem="G#protein_family_or_group">antibodies</cons> against the <cons sem="G#protein_family_or_group">enzyme</cons>.</sentence> > 5760c6416 < MAbs against the dUTPase reacted with a protein of approximately 31 kDa in 12-O-tetradecanoyl-phorbol-13- acetate (TPA)-stimulated B cells harbouring either type 1 or type 2 EBV. --- > MAbs against the dUTPase reacted with a protein of approximately 31 kDa in 12-O-tetradecanoyl-phorbol-13- acetate (TPA)-stimulated B cells harbouring either type 1 or type 2 EBV. 5762c6418 < We demonstrated that the virus dUTPase isolated from EBV-infected cells is a phosphoprotein. --- > We demonstrated that the virus dUTPase isolated from EBV-infected cells is a phosphoprotein. 5765c6421 < This indicated that the dUTPase is expressed during EBV replication and reactivation. --- > This indicated that the dUTPase is expressed during EBV replication and reactivation. 5774c6430,6432 < The <cons sem="G#protein_domain_or_region">catalytic domain</cons> of <cons sem="G#protein_molecule">pp56(lck)</cons>, but not its <cons sem="G#protein_domain_or_region">regulatory domain</cons>, is sufficient for inducing <cons sem="G#other_name"><cons sem="G#protein_molecule">IL-2</cons> production</cons>. --- > > <sentence>The <cons sem="G#protein_domain_or_region">catalytic domain</cons> of <cons sem="G#protein_molecule">pp56(lck)</cons>, but not its <cons sem="G#protein_domain_or_region">regulatory domain</cons>, is sufficient for inducing <cons sem="G#other_name"><cons sem="G#protein_molecule">IL-2</cons> production</cons>.</sentence> > 5776c6434 < The lymphoid src kinase pp56(lck) has been shown to be essential for the induction of different T lymphocyte responses, including CD4- mediated enhancement of Ag-induced T cell activation, early T cell differentiation, induction of IL-2 production, and cytotoxicity. --- > The lymphoid src kinase pp56(lck) has been shown to be essential for the induction of different T lymphocyte responses, including CD4- mediated enhancement of Ag-induced T cell activation, early T cell differentiation, induction of IL-2 production, and cytotoxicity. 5778c6436 < However, it has been recently reported that the NH2 regulatory domain is sufficient to mediate CD4 accessory function. --- > However, it has been recently reported that the NH2 regulatory domain is sufficient to mediate CD4 accessory function. 5781c6439 < Only the catalytic, but not the NH2 regulatory, domain of pp56(lck) was able to induce NF-AT region transactivation on its own and to cooperate with other intracellular signals to trigger this response. --- > Only the catalytic, but not the NH2 regulatory, domain of pp56(lck) was able to induce NF-AT region transactivation on its own and to cooperate with other intracellular signals to trigger this response. 5792c6450,6452 < [The changes in glucocorticoid receptors in <cons sem="G#cell_type">peripheral leukocytes</cons> in <cons sem="G#multi_cell">asthmatic subjects</cons>] --- > > <sentence>[The changes in glucocorticoid receptors in <cons sem="G#cell_type">peripheral leukocytes</cons> in <cons sem="G#multi_cell">asthmatic subjects</cons>]</sentence> > 5794c6454 < The number of glucocorticoid receptors (GCR) in peripheral leukocytes was determined by radioligand-binding assay in extrinsic and intrinsic asthmatics. --- > The number of glucocorticoid receptors (GCR) in peripheral leukocytes was determined by radioligand-binding assay in extrinsic and intrinsic asthmatics. 5798,5800c6458,6460 < No difference in plasma cortisol level was found between asthmatics and healthy subjects. < These findings suggest that there is no primary and general impairment of glucocorticoid metabolism in the asthmatics, but the number of GCR in the asthmatics is lower than that in healthy controls. < The decrease of the number of GCR in asthmatics, we think, is related to heredity and repeated attacks of asthma. --- > No difference in plasma cortisol level was found between asthmatics and healthy subjects. > These findings suggest that there is no primary and general impairment of glucocorticoid metabolism in the asthmatics, but the number of GCR in the asthmatics is lower than that in healthy controls. > The decrease of the number of GCR in asthmatics, we think, is related to heredity and repeated attacks of asthma. 5808c6468,6470 < Novel <cons sem="G#protein_family_or_group">aldosterone receptors</cons>: specificity-conferring mechanism at the level of the <cons sem="G#cell_component">cell membrane</cons>. --- > > <sentence>Novel <cons sem="G#protein_family_or_group">aldosterone receptors</cons>: specificity-conferring mechanism at the level of the <cons sem="G#cell_component">cell membrane</cons>.</sentence> > 5826c6488,6490 < The <cons sem="G#protein_family_or_group">macrophage transcription factor</cons> <cons sem="G#protein_molecule">PU.1</cons> directs tissue-specific expression of the <cons sem="G#protein_molecule">macrophage colony-stimulating factor receptor</cons>. --- > > <sentence>The <cons sem="G#protein_family_or_group">macrophage transcription factor</cons> <cons sem="G#protein_molecule">PU.1</cons> directs tissue-specific expression of the <cons sem="G#protein_molecule">macrophage colony-stimulating factor receptor</cons>.</sentence> > 5843c6507,6509 < Increased <cons sem="G#other_name">natural killer cell activity</cons> correlates with low or negative expression of the <cons sem="G#DNA_domain_or_region">HER-2/neu oncogene</cons> in <cons sem="G#multi_cell">patients</cons> with <cons sem="G#other_name">breast cancer</cons>. --- > > <sentence>Increased <cons sem="G#other_name">natural killer cell activity</cons> correlates with low or negative expression of the <cons sem="G#DNA_domain_or_region">HER-2/neu oncogene</cons> in <cons sem="G#multi_cell">patients</cons> with <cons sem="G#other_name">breast cancer</cons>.</sentence> > 5865c6531,6533 < [The value of the clinical test of <cons sem="G#protein_family_or_group"><cons sem="G#lipid">glucocorticoid</cons> receptors</cons> of <cons sem="G#cell_type">peripheral blood leukocytes</cons> in <cons sem="G#multi_cell">patients</cons> with <cons sem="G#other_name">chronic pulmonary heart disease</cons>] --- > > <sentence>[The value of the clinical test of <cons sem="G#protein_family_or_group"><cons sem="G#lipid">glucocorticoid</cons> receptors</cons> of <cons sem="G#cell_type">peripheral blood leukocytes</cons> in <cons sem="G#multi_cell">patients</cons> with <cons sem="G#other_name">chronic pulmonary heart disease</cons>]</sentence> > 5882c6550,6552 < Signaling via <cons sem="G#protein_molecule">IL-2</cons> and <cons sem="G#protein_molecule">IL-4</cons> in <cons sem="G#cell_line"><cons sem="G#protein_molecule">JAK3</cons>-deficient severe combined immunodeficiency lymphocytes</cons>: <cons sem="G#other_name"><cons sem="G#protein_molecule">JAK3</cons>-dependent and independent pathways</cons>. --- > > <sentence>Signaling via <cons sem="G#protein_molecule">IL-2</cons> and <cons sem="G#protein_molecule">IL-4</cons> in <cons sem="G#cell_line"><cons sem="G#protein_molecule">JAK3</cons>-deficient severe combined immunodeficiency lymphocytes</cons>: <cons sem="G#other_name"><cons sem="G#protein_molecule">JAK3</cons>-dependent and independent pathways</cons>.</sentence> > 5898c6568,6570 < <cons sem="G#protein_molecule">Elf-1</cons> and <cons sem="G#protein_molecule">Stat5</cons> bind to a critical element in a new enhancer of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">human interleukin-2 receptor alpha</cons> gene</cons> [published erratum appears in Mol Cell Biol 1997 Apr;17(4):2351] --- > > <sentence><cons sem="G#protein_molecule">Elf-1</cons> and <cons sem="G#protein_molecule">Stat5</cons> bind to a critical element in a new enhancer of the <cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">human interleukin-2 receptor alpha</cons> gene</cons> [published erratum appears in Mol Cell Biol 1997 Apr;17(4):2351]</sentence> > 5912c6584 < These are essential for IL- 2 inducibility of PRRIII/CAT reporter constructs. --- > These are essential for IL- 2 inducibility of PRRIII/CAT reporter constructs. 5914,5915c6586,6587 < To confirm the physiological relevance of these findings, we carried out in vivo footprinting experiments which showed that stimulation of IL-2R alpha expression correlated with occupancy of the GASd element. < Our data demonstrate a major role of the GASd/EBSd element in IL-2R alpha regulation and suggest that the T-cell-specific Elf-1 factor can serve as a transcriptional repressor. --- > To confirm the physiological relevance of these findings, we carried out in vivo footprinting experiments which showed that stimulation of IL-2R alpha expression correlated with occupancy of the GASd element. > Our data demonstrate a major role of the GASd/EBSd element in IL-2R alpha regulation and suggest that the T-cell-specific Elf-1 factor can serve as a transcriptional repressor. 5923c6595,6597 < Signal transduction by <cons sem="G#protein_molecule">DR3</cons>, a <cons sem="G#protein_family_or_group"><cons sem="G#protein_domain_or_region">death domain</cons>-containing receptor</cons> related to <cons sem="G#protein_molecule">TNFR-1</cons> and <cons sem="G#protein_molecule">CD95</cons>. --- > > <sentence>Signal transduction by <cons sem="G#protein_molecule">DR3</cons>, a <cons sem="G#protein_family_or_group"><cons sem="G#protein_domain_or_region">death domain</cons>-containing receptor</cons> related to <cons sem="G#protein_molecule">TNFR-1</cons> and <cons sem="G#protein_molecule">CD95</cons>.</sentence> > 5936c6610,6612 < Differential nuclear localization of <cons sem="G#protein_subunit">p50</cons>, <cons sem="G#protein_subunit">p52</cons>, and <cons sem="G#protein_molecule">RelB</cons> proteins in <cons sem="G#cell_type">human accessory cells</cons> of the <cons sem="G#other_name">immune response</cons> <cons sem="G#other_name">in situ</cons>. --- > > <sentence>Differential nuclear localization of <cons sem="G#protein_subunit">p50</cons>, <cons sem="G#protein_subunit">p52</cons>, and <cons sem="G#protein_molecule">RelB</cons> proteins in <cons sem="G#cell_type">human accessory cells</cons> of the <cons sem="G#other_name">immune response</cons> <cons sem="G#other_name">in situ</cons>.</sentence> > 5949c6625 < These results show that, physiologically, high levels of nuclear of p50, p52 and RelB are restricted to accessory cells of the immune system, which include FDC in GC, and DC and macrophages in the T cell zone, that specialized scavenger macrophages from GC do not have detectable levels of p52 and RelB, whereas macrophages from the T cell area, known to present the antigen to T cells, do have both nuclear p52 and RelB, and that in the T cell zone, p52 and RelB are located in nuclei of both CD1a+, CD68+ or both, cells APC, whereas p50 is restricted to CD1a- and CD68- APC. --- > These results show that, physiologically, high levels of nuclear of p50, p52 and RelB are restricted to accessory cells of the immune system, which include FDC in GC, and DC and macrophages in the T cell zone, that specialized scavenger macrophages from GC do not have detectable levels of p52 and RelB, whereas macrophages from the T cell area, known to present the antigen to T cells, do have both nuclear p52 and RelB, and that in the T cell zone, p52 and RelB are located in nuclei of both CD1a+, CD68+ or both, cells APC, whereas p50 is restricted to CD1a- and CD68- APC. 5958c6634,6636 < <cons sem="(AND G#amino_acid_monomer G#amino_acid_monomer G#amino_acid_monomer)"><cons>Tyrosines</cons> <cons>113</cons>, <cons>128</cons>, and <cons>145</cons></cons> of <cons sem="G#protein_molecule">SLP-76</cons> are required for optimal augmentation of <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">NFAT promoter</cons> activity</cons>. --- > > <sentence><cons sem="(AND G#amino_acid_monomer G#amino_acid_monomer G#amino_acid_monomer)"><cons>Tyrosines</cons> <cons>113</cons>, <cons>128</cons>, and <cons>145</cons></cons> of <cons sem="G#protein_molecule">SLP-76</cons> are required for optimal augmentation of <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">NFAT promoter</cons> activity</cons>.</sentence> > 5972,5973c6650,6653 < <cons sem="G#DNA_domain_or_region">Human interferon regulatory factor 2 gene</cons>. < Intron-exon organization and functional analysis of <cons sem="G#DNA_domain_or_region">5'-flanking region</cons>. --- > > <sentence><cons sem="G#DNA_domain_or_region">Human interferon regulatory factor 2 gene</cons>.</sentence> > <sentence>Intron-exon organization and functional analysis of <cons sem="G#DNA_domain_or_region">5'-flanking region</cons>.</sentence> > 5981c6661 < These data suggest that interferon regulatory factor 1 not only triggers the activation of the interferon signal transduction pathway, but also may play a role in limiting the duration of this response by activating the transcription of IRF-2. --- > These data suggest that interferon regulatory factor 1 not only triggers the activation of the interferon signal transduction pathway, but also may play a role in limiting the duration of this response by activating the transcription of IRF-2. 5989c6669,6671 < <cons sem="G#protein_molecule">Interferon alpha</cons> selectively affects expression of the <cons sem="G#protein_molecule">human myeloid cell nuclear differentiation antigen</cons> in <cons sem="G#cell_type">late stage cells</cons> in the <cons sem="G#cell_type">monocytic</cons> but not the <cons sem="G#cell_type">granulocytic lineage</cons>. --- > > <sentence><cons sem="G#protein_molecule">Interferon alpha</cons> selectively affects expression of the <cons sem="G#protein_molecule">human myeloid cell nuclear differentiation antigen</cons> in <cons sem="G#cell_type">late stage cells</cons> in the <cons sem="G#cell_type">monocytic</cons> but not the <cons sem="G#cell_type">granulocytic lineage</cons>.</sentence> > 6009c6691,6693 < Involvement of <cons sem="G#protein_family_or_group">transcription factor</cons> <cons sem="G#protein_molecule">YB-1</cons> in <cons sem="G#other_name"><cons sem="G#virus">human T-cell lymphotropic virus type I</cons> basal gene expression</cons>. --- > > <sentence>Involvement of <cons sem="G#protein_family_or_group">transcription factor</cons> <cons sem="G#protein_molecule">YB-1</cons> in <cons sem="G#other_name"><cons sem="G#virus">human T-cell lymphotropic virus type I</cons> basal gene expression</cons>.</sentence> > 6028c6712,6714 < Changes in <cons sem="G#other_name"><cons sem="G#amino_acid_monomer">triiodothyronine</cons> (<cons sem="G#amino_acid_monomer">T3</cons>) mononuclear leukocyte receptor kinetics</cons> after <cons sem="G#other_name"><cons sem="G#amino_acid_monomer">T3</cons> administration</cons> and multiple <cons sem="G#other_name">cold-air exposures</cons>. --- > > <sentence>Changes in <cons sem="G#other_name"><cons sem="G#amino_acid_monomer">triiodothyronine</cons> (<cons sem="G#amino_acid_monomer">T3</cons>) mononuclear leukocyte receptor kinetics</cons> after <cons sem="G#other_name"><cons sem="G#amino_acid_monomer">T3</cons> administration</cons> and multiple <cons sem="G#other_name">cold-air exposures</cons>.</sentence> > 6038c6724 < The log10Kd increased 0.304 +/- 0.139 (p < 0.04) and the log10MBC increased 0.49 +/- 0.10 (p < 0.001) in the T3+ subjects compared to baseline. --- > The log10Kd increased 0.304 +/- 0.139 (p < 0.04) and the log10MBC increased 0.49 +/- 0.10 (p < 0.001) in the T3+ subjects compared to baseline. 6049c6735,6737 < <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">HIV-1 LTR</cons> activity</cons> in <cons sem="G#cell_line">human CD40-activated B lymphocytes</cons> is dependent on <cons sem="G#protein_molecule">NF-kappaB</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">HIV-1 LTR</cons> activity</cons> in <cons sem="G#cell_line">human CD40-activated B lymphocytes</cons> is dependent on <cons sem="G#protein_molecule">NF-kappaB</cons>.</sentence> > 6063c6751,6753 < Sequence analysis and expression in <cons sem="G#cell_type">cultured lymphocytes</cons> of the human <cons sem="G#DNA_domain_or_region">FOSB gene</cons> (<cons sem="G#DNA_domain_or_region">G0S3</cons>). --- > > <sentence>Sequence analysis and expression in <cons sem="G#cell_type">cultured lymphocytes</cons> of the human <cons sem="G#DNA_domain_or_region">FOSB gene</cons> (<cons sem="G#DNA_domain_or_region">G0S3</cons>).</sentence> > 6085c6775,6777 < Susceptibility to <cons sem="G#cell_type">natural killer cells</cons> and down regulation of <cons sem="G#other_name">MHC class I expression</cons> in <cons sem="G#cell_line"><cons sem="G#virus">adenovirus 12</cons> transformed cells</cons> are regulated by different <cons sem="G#DNA_domain_or_region">E1A domains</cons>. --- > > <sentence>Susceptibility to <cons sem="G#cell_type">natural killer cells</cons> and down regulation of <cons sem="G#other_name"><cons sem="G#protein_complex">MHC</cons> class I expression</cons> in <cons sem="G#cell_line"><cons sem="G#virus">adenovirus 12</cons> transformed cells</cons> are regulated by different <cons sem="G#DNA_domain_or_region">E1A domains</cons>.</sentence> > 6101c6793,6795 < <cons sem="G#other_name">Cell specific expression</cons> of <cons sem="G#DNA_domain_or_region">human Bruton's agammaglobulinemia tyrosine kinase gene</cons> (<cons sem="G#protein_molecule">Btk</cons>) is regulated by <cons sem="G#protein_family_or_group">Sp1-</cons> and <cons sem="G#protein_family_or_group">Spi-1/PU.1-family members</cons>. --- > > <sentence><cons sem="G#other_name">Cell specific expression</cons> of <cons sem="G#DNA_domain_or_region">human Bruton's agammaglobulinemia tyrosine kinase gene</cons> (<cons sem="G#protein_molecule">Btk</cons>) is regulated by <cons sem="G#protein_family_or_group">Sp1-</cons> and <cons sem="G#protein_family_or_group">Spi-1/PU.1-family members</cons>.</sentence> > 6121c6815,6817 < <cons sem="G#other_name">T cell response</cons> to <cons sem="G#protein_family_or_group">Epstein-Barr virus transactivators</cons> in <cons sem="G#other_name">chronic rheumatoid arthritis</cons>. --- > > <sentence><cons sem="G#other_name">T cell response</cons> to <cons sem="G#protein_family_or_group">Epstein-Barr virus transactivators</cons> in <cons sem="G#other_name">chronic rheumatoid arthritis</cons>.</sentence> > 6125c6821 < Here we show that a large fraction of T cells infiltrating affected joints from a patient with chronic rheumatoid arthritis recognizes two EBV transactivators (BZLF1 and BMLF1) in a major histocompatibility complex-restricted fashion. --- > Here we show that a large fraction of T cells infiltrating affected joints from a patient with chronic rheumatoid arthritis recognizes two EBV transactivators (BZLF1 and BMLF1) in a major histocompatibility complex-restricted fashion. 6128c6824 < They also demonstrate for the first time the occurrence of T cell responses against EBV transactivating factors, which might be central in the control of virus reactivation. --- > They also demonstrate for the first time the occurrence of T cell responses against EBV transactivating factors, which might be central in the control of virus reactivation. 6136c6832,6834 < <cons sem="G#other_name"><cons sem="G#protein_molecule">CD14</cons>-mediated signal pathway</cons> of <cons sem="G#lipid"><cons sem="G#mono_cell">Porphyromonas gingivalis</cons> lipopolysaccharide</cons> in <cons sem="G#cell_type">human gingival fibroblasts</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#protein_molecule">CD14</cons>-mediated signal pathway</cons> of <cons sem="G#lipid"><cons sem="G#mono_cell">Porphyromonas gingivalis</cons> lipopolysaccharide</cons> in <cons sem="G#cell_type">human gingival fibroblasts</cons>.</sentence> > 6140c6838 < Therefore, it is important to determine whether CD14 is expressed in gingival fibroblasts and to define the P-LPS-mediated signal-transducing mechanism in the cells. --- > Therefore, it is important to determine whether CD14 is expressed in gingival fibroblasts and to define the P-LPS-mediated signal-transducing mechanism in the cells. 6155c6853,6855 < <cons sem="G#protein_molecule">rel</cons> Is rapidly tyrosine-phosphorylated following <cons sem="G#other_name"><cons sem="G#protein_family_or_group">granulocyte-colony stimulating factor</cons> treatment</cons> of human neutrophils. --- > > <sentence><cons sem="G#protein_molecule">rel</cons> Is rapidly tyrosine-phosphorylated following <cons sem="G#other_name"><cons sem="G#protein_family_or_group">granulocyte-colony stimulating factor</cons> treatment</cons> of human neutrophils.</sentence> > 6160c6860 < Antiphosphotyrosine immunoblots of whole cell lysates prepared from neutrophils show that the G-CSF rapidly induces prominent tyrosine phosphorylation of a protein of a relative molecular mass of 80 kDa. --- > Antiphosphotyrosine immunoblots of whole cell lysates prepared from neutrophils show that the G-CSF rapidly induces prominent tyrosine phosphorylation of a protein of a relative molecular mass of 80 kDa. 6173c6873,6875 < Patterns of <cons sem="G#other_name"><cons sem="G#protein_family_or_group">Pan</cons> expression</cons> and role of <cons sem="G#protein_family_or_group">Pan proteins</cons> in endocrine cell <cons sem="G#other_name">type-specific complex formation</cons>. --- > > <sentence>Patterns of <cons sem="G#other_name"><cons sem="G#protein_family_or_group">Pan</cons> expression</cons> and role of <cons sem="G#protein_family_or_group">Pan proteins</cons> in endocrine cell <cons sem="G#other_name">type-specific complex formation</cons>.</sentence> > 6177,6179c6879,6881 < Studies of cell lines representing endocrine, fibroblast, and lymphoid lineages using polyclonal antisera to detect E2A proteins have suggested that significant E2A protein expression is restricted to B-lymphocytes. < We have developed a monoclonal antibody, Yae, which is specific for Pan/E2A proteins, and have used the Yae antibody to examine a variety of endocrine and nonendocrine cell lineages for differences in Pan/E2A protein expression, subcellular localization, and heteromeric complex formation. < In contrast to previous results obtained using polyclonal antiseras to detect Pan/E2A proteins, we report comparable levels of Pan proteins in GH/PRL- and insulin-producing, B- and T-lymphocyte cells. --- > Studies of cell lines representing endocrine, fibroblast, and lymphoid lineages using polyclonal antisera to detect E2A proteins have suggested that significant E2A protein expression is restricted to B-lymphocytes. > We have developed a monoclonal antibody, Yae, which is specific for Pan/E2A proteins, and have used the Yae antibody to examine a variety of endocrine and nonendocrine cell lineages for differences in Pan/E2A protein expression, subcellular localization, and heteromeric complex formation. > In contrast to previous results obtained using polyclonal antiseras to detect Pan/E2A proteins, we report comparable levels of Pan proteins in GH/PRL- and insulin-producing, B- and T-lymphocyte cells. 6189c6891,6893 < Visualization of the <cons sem="G#protein_subunit">endogenous <cons sem="G#protein_complex">NF-kappa B</cons> p50 subunit</cons> in the <cons sem="G#cell_component">nucleus</cons> of <cons sem="G#cell_type">follicular dendritic cells</cons> in <cons sem="G#tissue">germinal centers</cons>. --- > > <sentence>Visualization of the <cons sem="G#protein_subunit">endogenous <cons sem="G#protein_complex">NF-kappa B</cons> p50 subunit</cons> in the <cons sem="G#cell_component">nucleus</cons> of <cons sem="G#cell_type">follicular dendritic cells</cons> in <cons sem="G#tissue">germinal centers</cons>.</sentence> > 6212c6916,6918 < Cloning and characterization of <cons sem="G#protein_molecule">NF-ATc</cons> and <cons sem="G#protein_molecule">NF-ATp</cons>: the <cons sem="G#cell_component">cytoplasm</cons>ic components of <cons sem="G#protein_complex">NF-AT</cons>. --- > > <sentence>Cloning and characterization of <cons sem="G#protein_molecule">NF-ATc</cons> and <cons sem="G#protein_molecule">NF-ATp</cons>: the <cons sem="G#cell_component">cytoplasmic components</cons> of <cons sem="G#protein_complex">NF-AT</cons>.</sentence> > 6231c6937,6939 < Induction of <cons sem="G#protein_molecule">vascular cell adhesion molecule-1</cons> by <cons sem="G#protein_molecule">low-density lipoprotein</cons>. --- > > <sentence>Induction of <cons sem="G#protein_molecule">vascular cell adhesion molecule-1</cons> by <cons sem="G#protein_molecule">low-density lipoprotein</cons>.</sentence> > 6249c6957,6959 < Involvement of <cons sem="G#other_name"><cons sem="G#protein_complex">nuclear factor-kappa B</cons> activation</cons> in <cons sem="G#other_name"><cons sem="G#protein_family_or_group">IgE</cons> synthesis</cons> in <cons sem="G#cell_type">human B cells</cons>. --- > > <sentence>Involvement of <cons sem="G#other_name"><cons sem="G#protein_complex">nuclear factor-kappa B</cons> activation</cons> in <cons sem="G#other_name"><cons sem="G#protein_family_or_group">IgE</cons> synthesis</cons> in <cons sem="G#cell_type">human B cells</cons>.</sentence> > 6252c6962 < Although NF-kappa B activates the expression of many genes involved in immune and inflammatory responses, little is known about the role of NF-kappa B activation in the induction of IgE synthesis in human B cells. --- > Although NF-kappa B activates the expression of many genes involved in immune and inflammatory responses, little is known about the role of NF-kappa B activation in the induction of IgE synthesis in human B cells. 6256c6966 < Although inhibition of IL-4-driven germline C epsilon transcription by NAC was not sufficient, the agent remarkably diminished anti-CD40 mAb- mediated up-regulation of germline C epsilon transcription. --- > Although inhibition of IL-4-driven germline C epsilon transcription by NAC was not sufficient, the agent remarkably diminished anti-CD40 mAb- mediated up-regulation of germline C epsilon transcription. 6268c6978,6980 < <cons sem="G#other_name"><cons sem="G#lipid">Prostaglandin E2</cons> induction</cons> of binding activity to <cons sem="G#DNA_domain_or_region">CRE</cons> and <cons sem="G#DNA_domain_or_region">AP-2 elements</cons> in <cons sem="G#cell_type">human T lymphocytes</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#lipid">Prostaglandin E2</cons> induction</cons> of binding activity to <cons sem="G#DNA_domain_or_region">CRE</cons> and <cons sem="G#DNA_domain_or_region">AP-2 elements</cons> in <cons sem="G#cell_type">human T lymphocytes</cons>.</sentence> > 6273c6985 < Since the okadaic acid, a potent protein phosphatase inhibitor, prolongs the induction of the binding activity, phosphorylation events are likely to occur. --- > Since the okadaic acid, a potent protein phosphatase inhibitor, prolongs the induction of the binding activity, phosphorylation events are likely to occur. 6284c6996,6998 < <cons sem="(AND G#cell_type G#cell_type)"><cons>Nasal NK-</cons> and <cons>T-cell</cons> <cons>lymphomas</cons></cons> share the same type of <cons sem="G#other_name"><cons sem="G#virus">Epstein-Barr virus</cons> latency</cons> as <cons sem="G#tissue">nasopharyngeal carcinoma</cons> and <cons sem="G#other_name">Hodgkin's disease</cons>. --- > > <sentence><cons sem="(AND G#cell_type G#cell_type)"><cons>Nasal NK-</cons> and <cons>T-cell</cons> <cons>lymphomas</cons></cons> share the same type of <cons sem="G#other_name"><cons sem="G#virus">Epstein-Barr virus</cons> latency</cons> as <cons sem="G#tissue">nasopharyngeal carcinoma</cons> and <cons sem="G#other_name">Hodgkin's disease</cons>.</sentence> > 6288c7002 < In this study, EBV gene expression was determined in 23 cases of nasal lymphoma (NL) by in situ hybridisation (ISH), reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry (IH). --- > In this study, EBV gene expression was determined in 23 cases of nasal lymphoma (NL) by in situ hybridisation (ISH), reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry (IH). 6293c7007 < Although 2 early lytic transcripts, BZLF1 and BHRF1, were also detected in 13 and 10 cases, respectively, the lack of ZEBRA staining in any case indicates that these lytic transcripts are most likely expressed by rare cells in the biopsies entering lytic cycle. --- > Although 2 early lytic transcripts, BZLF1 and BHRF1, were also detected in 13 and 10 cases, respectively, the lack of ZEBRA staining in any case indicates that these lytic transcripts are most likely expressed by rare cells in the biopsies entering lytic cycle. 6303c7017,7019 < Potent <cons sem="G#other_name">gene regulatory</cons> and <cons sem="G#other_name">antiproliferative activities</cons> of <cons sem="G#other_organic_compound">20-methyl analogues</cons> of <cons sem="G#lipid">1,25 dihydroxyvitamin D3</cons>. --- > > <sentence>Potent <cons sem="G#other_name">gene regulatory</cons> and <cons sem="G#other_name">antiproliferative activities</cons> of <cons sem="G#other_organic_compound">20-methyl analogues</cons> of <cons sem="G#lipid">1,25 dihydroxyvitamin D3</cons>.</sentence> > 6305c7021 < The biological active form of vitamin D3, 1,25-dihydroxyvitamin D3 (VD), regulates cellular growth and differentiation. --- > The biological active form of vitamin D3, 1,25-dihydroxyvitamin D3 (VD), regulates cellular growth and differentiation. 6315c7031 < This observation supports a model, in which promoter selectivity reflects the selectively increased antiproliferative effect of VD analogues. --- > This observation supports a model, in which promoter selectivity reflects the selectively increased antiproliferative effect of VD analogues. 6323c7039,7041 < <cons sem="G#other_name"><cons sem="G#atom">Calcium</cons>-dependent immediate-early gene induction</cons> in <cons sem="G#cell_type">lymphocytes</cons> is negatively regulated by <cons sem="G#protein_molecule">p21Ha-ras</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#atom">Calcium</cons>-dependent <cons sem="G#DNA_family_or_group">immediate-early gene</cons> induction</cons> in <cons sem="G#cell_type">lymphocytes</cons> is negatively regulated by <cons sem="G#protein_molecule">p21Ha-ras</cons>.</sentence> > 6332c7050 < A later result of inhibition of this activation pathway by p21(ras) was down-regulation of the activity of the transcription factor AP-1 and subsequent coordinate reductions in IL-2 gene expression and protein production. --- > A later result of inhibition of this activation pathway by p21(ras) was down-regulation of the activity of the transcription factor AP-1 and subsequent coordinate reductions in IL-2 gene expression and protein production. 6341c7059,7061 < <cons sem="G#protein_molecule">Calcineurin</cons> acts in synergy with <cons sem="G#other_organic_compound">PMA</cons> to inactivate <cons sem="G#protein_molecule">I kappa B/MAD3</cons>, an inhibitor of <cons sem="G#protein_complex">NF-kappa B</cons>. --- > > <sentence><cons sem="G#protein_molecule">Calcineurin</cons> acts in synergy with <cons sem="G#other_organic_compound">PMA</cons> to inactivate <cons sem="G#protein_molecule">I kappa B/MAD3</cons>, an inhibitor of <cons sem="G#protein_complex">NF-kappa B</cons>.</sentence> > 6356c7076,7078 < Detection of <cons sem="G#other_name">minimal residual disease</cons> in a <cons sem="G#multi_cell">patient</cons> with <cons sem="G#other_name">acute promyelocytic leukemia</cons> by <cons sem="G#other_name">RT-PCR</cons>: necessity of <cons sem="G#other_name">chemotherapy</cons> following <cons sem="G#other_name">ATRA therapy</cons>. --- > > <sentence>Detection of <cons sem="G#other_name">minimal residual disease</cons> in a <cons sem="G#multi_cell">patient</cons> with <cons sem="G#other_name">acute promyelocytic leukemia</cons> by <cons sem="G#other_name">RT-PCR</cons>: necessity of <cons sem="G#other_name">chemotherapy</cons> following <cons sem="G#other_name">ATRA therapy</cons>.</sentence> > 6370c7092,7094 < <cons sem="G#other_name"><cons sem="G#lipid">Glucocorticoid</cons>-mediated inhibition</cons> of <cons sem="(AND G#other_name G#other_name)"><cons>interleukin-2 receptor</cons> <cons>alpha</cons> and <cons>- beta</cons> <cons>subunit expression</cons></cons> by human T cells. --- > > <sentence><cons sem="G#other_name"><cons sem="G#lipid">Glucocorticoid</cons>-mediated inhibition</cons> of <cons sem="(AND G#other_name G#other_name)"><cons>interleukin-2 receptor</cons> <cons>alpha</cons> and <cons>- beta</cons> <cons>subunit expression</cons></cons> by human T cells.</sentence> > 6390c7114,7116 < Alteration of structural order of <cons sem="G#cell_component">human erythrocyte ghost membrane</cons> by <cons sem="G#lipid">glucocorticoids</cons> and the influence of the <cons sem="G#other_organic_compound"><cons sem="G#lipid">glucocorticoid</cons> receptor antagonist</cons> RU 486. --- > > <sentence>Alteration of structural order of <cons sem="G#cell_component">human erythrocyte ghost membrane</cons> by <cons sem="G#lipid">glucocorticoids</cons> and the influence of the <cons sem="G#other_organic_compound"><cons sem="G#lipid">glucocorticoid</cons> receptor antagonist</cons> RU 486.</sentence> > 6409c7135,7137 < Mutation of <cons sem="G#amino_acid_monomer">tyrosines</cons> <cons sem="G#amino_acid_monomer">492/493</cons> in the <cons sem="G#protein_domain_or_region">kinase domain</cons> of <cons sem="G#protein_molecule">ZAP-70</cons> affects multiple <cons sem="G#other_name">T-cell receptor signaling pathways</cons>. --- > > <sentence>Mutation of <cons sem="G#amino_acid_monomer">tyrosines</cons> <cons sem="G#amino_acid_monomer">492/493</cons> in the <cons sem="G#protein_domain_or_region">kinase domain</cons> of <cons sem="G#protein_molecule">ZAP-70</cons> affects multiple <cons sem="G#other_name"><cons sem="G#protein_family_or_group">T-cell receptor</cons> signaling pathways</cons>.</sentence> > 6428c7156,7158 < Effects of <cons sem="G#lipid">glucocorticoids</cons> on <cons sem="G#other_name">lymphocyte activation</cons> in <cons sem="G#multi_cell">patients</cons> with <cons sem="(AND G#other_name G#other_name)"><cons>steroid-sensitive</cons> and <cons>steroid-resistant</cons> <cons>asthma</cons></cons>. --- > > <sentence>Effects of <cons sem="G#lipid">glucocorticoids</cons> on <cons sem="G#other_name">lymphocyte activation</cons> in <cons sem="G#multi_cell">patients</cons> with <cons sem="(AND G#other_name G#other_name)"><cons>steroid-sensitive</cons> and <cons>steroid-resistant</cons> <cons>asthma</cons></cons>.</sentence> > 6447c7177,7179 < Characterization of the <cons sem="G#DNA_domain_or_region">murine cyclin-dependent kinase inhibitor gene</cons> <cons sem="G#DNA_domain_or_region">p27Kip1</cons>. --- > > <sentence>Characterization of the <cons sem="G#DNA_domain_or_region">murine cyclin-dependent kinase inhibitor gene</cons> <cons sem="G#DNA_domain_or_region">p27Kip1</cons>.</sentence> > 6451c7183 < Interestingly, the expression level of p27Kip1 mRNA was maximal in resting Go T-cells and rapidly declined following anti-CD3 activation. --- > Interestingly, the expression level of p27Kip1 mRNA was maximal in resting Go T-cells and rapidly declined following anti-CD3 activation. 6465c7197,7199 < <cons sem="G#protein_molecule">Nuclear NF-ATp</cons> is a hallmark of <cons sem="G#cell_type">unstimulated B cells</cons> from <cons sem="G#multi_cell">B-CLL <cons sem="G#multi_cell">patients</cons></cons>. --- > > <sentence><cons sem="G#protein_molecule">Nuclear NF-ATp</cons> is a hallmark of <cons sem="G#cell_type">unstimulated B cells</cons> from <cons sem="G#multi_cell">B-CLL <cons sem="G#multi_cell">patients</cons></cons>.</sentence> > 6482c7216,7218 < <cons sem="G#cell_type">Naive (CD45RA+) T lymphocytes</cons> are more sensitive to <cons sem="G#other_name">oxidative stress- induced signals</cons> than <cons sem="G#cell_type">memory (CD45RO+) cells</cons>. --- > > <sentence><cons sem="G#cell_type">Naive (CD45RA+) T lymphocytes</cons> are more sensitive to <cons sem="G#other_name">oxidative stress- induced signals</cons> than <cons sem="G#cell_type">memory (CD45RO+) cells</cons>.</sentence> > 6499c7235,7237 < Rapid shuttling of <cons sem="G#protein_family_or_group">NF-AT</cons> in discrimination of <cons sem="G#other_name"><cons sem="G#atom">Ca2+</cons> signals</cons> and immunosuppression. --- > > <sentence>Rapid shuttling of <cons sem="G#protein_family_or_group">NF-AT</cons> in discrimination of <cons sem="G#other_name"><cons sem="G#atom">Ca2+</cons> signals</cons> and immunosuppression.</sentence> > 6513c7251,7253 < Autoregulation of the <cons sem="G#protein_family_or_group"><cons sem="G#protein_complex">NF-kappa B</cons> transactivator</cons> <cons sem="G#protein_subunit">RelA</cons> (<cons sem="G#protein_subunit">p65</cons>) by multiple <cons sem="G#protein_family_or_group">cytoplasmic inhibitors</cons> containing <cons sem="G#protein_substructure">ankyrin motifs</cons>. --- > > <sentence>Autoregulation of the <cons sem="G#protein_family_or_group"><cons sem="G#protein_complex">NF-kappa B</cons> transactivator</cons> <cons sem="G#protein_subunit">RelA</cons> (<cons sem="G#protein_subunit">p65</cons>) by multiple <cons sem="G#protein_family_or_group">cytoplasmic inhibitors</cons> containing <cons sem="G#protein_substructure">ankyrin motifs</cons>.</sentence> > 6528,6529c7268,7271 < Effects of <cons sem="G#protein_molecule">CD45</cons> on <cons sem="G#protein_complex">NF-kappa B</cons>. < Implications for replication of <cons sem="G#virus">HIV-1</cons>. --- > > <sentence>Effects of <cons sem="G#protein_molecule">CD45</cons> on <cons sem="G#protein_complex">NF-kappa B</cons>.</sentence> > <sentence>Implications for replication of <cons sem="G#virus">HIV-1</cons>.</sentence> > 6547c7289,7291 < <cons sem="G#protein_molecule">Calcineurin</cons> potentiates activation of the <cons sem="G#DNA_domain_or_region">granulocyte-macrophage colony- stimulating factor gene</cons> in <cons sem="G#cell_type">T cells</cons>: involvement of the <cons sem="G#DNA_domain_or_region">conserved lymphokine element 0</cons>. --- > > <sentence><cons sem="G#protein_molecule">Calcineurin</cons> potentiates activation of the <cons sem="G#DNA_domain_or_region">granulocyte-macrophage colony- stimulating factor gene</cons> in <cons sem="G#cell_type">T cells</cons>: involvement of the <cons sem="G#DNA_domain_or_region">conserved lymphokine element 0</cons>.</sentence> > 6566c7310,7312 < Alternate <cons sem="G#other_name">immune system targets</cons> for <cons sem="G#other_organic_compound">TCDD</cons>: <cons sem="G#cell_type">lymphocyte stem cells</cons> and <cons sem="G#other_name"><cons sem="G#cell_type">extrathymic T-cell</cons> development</cons>. --- > > <sentence>Alternate <cons sem="G#other_name">immune system targets</cons> for <cons sem="G#other_organic_compound">TCDD</cons>: <cons sem="G#cell_type">lymphocyte stem cells</cons> and <cons sem="G#other_name"><cons sem="G#cell_type">extrathymic T-cell</cons> development</cons>.</sentence> > 6580c7326,7328 < Identification of <cons sem="G#DNA_domain_or_region">Bcd</cons>, a novel <cons sem="G#DNA_family_or_group">proto-oncogene</cons> expressed in <cons sem="G#cell_type">B-cells</cons>. --- > > <sentence>Identification of <cons sem="G#DNA_domain_or_region">Bcd</cons>, a novel <cons sem="G#DNA_family_or_group">proto-oncogene</cons> expressed in <cons sem="G#cell_type">B-cells</cons>.</sentence> > 6600c7348,7350 < A <cons sem="G#DNA_domain_or_region">novel <cons sem="G#DNA_domain_or_region">SP-1 site</cons></cons> in the <cons sem="G#DNA_domain_or_region">human interleukin-1 beta promoter</cons> confers <cons sem="G#other_name">preferential transcriptional activity</cons> in <cons sem="G#cell_type">keratinocytes</cons>. --- > > <sentence>A <cons sem="G#DNA_domain_or_region">novel <cons sem="G#DNA_domain_or_region">SP-1 site</cons></cons> in the <cons sem="G#DNA_domain_or_region">human interleukin-1 beta promoter</cons> confers <cons sem="G#other_name">preferential transcriptional activity</cons> in <cons sem="G#cell_type">keratinocytes</cons>.</sentence> > 6617c7367,7369 < Expression of <cons sem="G#protein_molecule">Egr-1</cons> correlates with the transformed phenotype and the type of viral latency in <cons sem="G#cell_line"><cons sem="G#DNA_family_or_group"><cons sem="G#virus">EBV</cons> genome</cons> positive lymphoid cell lines</cons>. --- > > <sentence>Expression of <cons sem="G#protein_molecule">Egr-1</cons> correlates with the transformed phenotype and the type of viral latency in <cons sem="G#cell_line"><cons sem="G#DNA_family_or_group"><cons sem="G#virus">EBV</cons> genome</cons> positive lymphoid cell lines</cons>.</sentence> > 6633c7385,7387 < Expression of <cons sem="G#DNA_family_or_group">erythroid-specific genes</cons> in <cons sem="G#other_name">megakaryoblastic disorders</cons>. --- > > <sentence>Expression of <cons sem="G#DNA_family_or_group">erythroid-specific genes</cons> in <cons sem="G#other_name">megakaryoblastic disorders</cons>.</sentence> > 6646c7400,7402 < <cons sem="G#protein_molecule">Stat3</cons> recruitment by two distinct <cons sem="G#protein_domain_or_region">ligand-induced, tyrosine- phosphorylated docking sites</cons> in the <cons sem="G#protein_domain_or_region"><cons sem="G#protein_molecule">interleukin-10 receptor</cons> intracellular domain</cons>. --- > > <sentence><cons sem="G#protein_molecule">Stat3</cons> recruitment by two distinct <cons sem="G#protein_domain_or_region">ligand-induced, tyrosine- phosphorylated docking sites</cons> in the <cons sem="G#protein_domain_or_region"><cons sem="G#protein_molecule">interleukin-10 receptor</cons> intracellular domain</cons>.</sentence> > 6648c7404 < Recent work has shown that IL-10 induces activation of the JAK-STAT signaling pathway. --- > Recent work has shown that IL-10 induces activation of the JAK-STAT signaling pathway. 6664c7420,7422 < Silencing of <cons sem="G#other_name">human fetal globin expression</cons> is impaired in the absence of the <cons sem="G#protein_family_or_group">adult beta-globin gene activator protein</cons> <cons sem="G#protein_molecule">EKLF</cons>. --- > > <sentence>Silencing of <cons sem="G#other_name">human fetal <cons sem="G#protein_family_or_group">globin</cons> expression</cons> is impaired in the absence of the <cons sem="G#protein_family_or_group">adult beta-globin gene activator protein</cons> <cons sem="G#protein_molecule">EKLF</cons>.</sentence> > 6680c7438,7440 < Stimulation of <cons sem="G#cell_type">human peripheral blood mononuclear cells</cons> by <cons sem="G#atom">zinc</cons> and related <cons sem="G#atom">cations</cons>. --- > > <sentence>Stimulation of <cons sem="G#cell_type">human peripheral blood mononuclear cells</cons> by <cons sem="G#atom">zinc</cons> and related <cons sem="G#atom">cations</cons>.</sentence> > 6695c7455,7457 < <cons sem="G#protein_molecule">E3</cons>, a <cons sem="G#protein_family_or_group">hematopoietic-specific transcript</cons> directly regulated by the <cons sem="G#protein_molecule">retinoic acid receptor alpha</cons>. --- > > <sentence><cons sem="G#protein_molecule">E3</cons>, a <cons sem="G#protein_family_or_group">hematopoietic-specific transcript</cons> directly regulated by the <cons sem="G#protein_molecule">retinoic acid receptor alpha</cons>.</sentence> > 6712c7474,7476 < <cons sem="G#other_name">Multifactor cis-dominant negative regulation</cons> of <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">IL-2</cons> gene</cons> expression</cons> in <cons sem="G#cell_type">anergized T cells</cons>. --- > > <sentence><cons sem="G#other_name">Multifactor cis-dominant negative regulation</cons> of <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region"><cons sem="G#protein_molecule">IL-2</cons> gene</cons> expression</cons> in <cons sem="G#cell_type">anergized T cells</cons>.</sentence> > 6728c7492,7494 < <cons sem="G#other_name">Severe combined immunodeficiency</cons> due to defective binding of the <cons sem="G#protein_molecule">nuclear factor of activated T cells</cons> in <cons sem="G#cell_type">T lymphocytes</cons> of two <cons sem="G#multi_cell">male siblings</cons>. --- > > <sentence><cons sem="G#other_name">Severe combined immunodeficiency</cons> due to defective binding of the <cons sem="G#protein_molecule">nuclear factor of activated T cells</cons> in <cons sem="G#cell_type">T lymphocytes</cons> of two <cons sem="G#multi_cell">male siblings</cons>.</sentence> > 6733c7499 < This multiple cytokine production deficiency could not be restored by IL-2 or co-stimulatory signals provided by antigen- presenting cells (APC). --- > This multiple cytokine production deficiency could not be restored by IL-2 or co-stimulatory signals provided by antigen- presenting cells (APC). 6736c7502 < To determine whether the functional defect of the patients' T cells was due to the absence or abnormal binding of transcription factors involved in cytokine gene expression, electrophoretic mobility shift assays were used to examine the DNA binding of AP-1, Oct, CREB, SP1, NF-kappa B and the nuclear factor of activated T cells (NF-AT) to their respective response elements in the promoter of the IL-2 gene. --- > To determine whether the functional defect of the patients' T cells was due to the absence or abnormal binding of transcription factors involved in cytokine gene expression, electrophoretic mobility shift assays were used to examine the DNA binding of AP-1, Oct, CREB, SP1, NF-kappa B and the nuclear factor of activated T cells (NF-AT) to their respective response elements in the promoter of the IL-2 gene. 6738c7504 < Our results strongly suggest that this NF-AT/DNA binding defect is responsible for the multiple cytokine deficiency and the SCID phenotype observed in the two infant brothers. --- > Our results strongly suggest that this NF-AT/DNA binding defect is responsible for the multiple cytokine deficiency and the SCID phenotype observed in the two infant brothers. 6746c7512,7514 < <cons sem="G#DNA_domain_or_region">oriP</cons> is essential for <cons sem="G#other_name">EBNA gene promoter activity</cons> in <cons sem="G#cell_line">Epstein-Barr virus- immortalized lymphoblastoid cell lines</cons>. --- > > <sentence><cons sem="G#DNA_domain_or_region">oriP</cons> is essential for <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">EBNA gene</cons> promoter activity</cons> in <cons sem="G#cell_line">Epstein-Barr virus- immortalized lymphoblastoid cell lines</cons>.</sentence> > 6766c7534,7536 < <cons sem="G#other_name">Protein-tyrosine kinase activation</cons> is required for <cons sem="G#other_name">lipopolysaccharide induction</cons> of <cons sem="G#protein_molecule">interleukin 1beta</cons> and <cons sem="G#other_name"><cons sem="G#protein_complex">NFkappaB</cons> activation</cons>, but not <cons sem="G#other_name"><cons sem="G#protein_complex">NFkappaB</cons> nuclear translocation</cons>. --- > > <sentence><cons sem="G#other_name">Protein-tyrosine kinase activation</cons> is required for <cons sem="G#other_name">lipopolysaccharide induction</cons> of <cons sem="G#protein_molecule">interleukin 1beta</cons> and <cons sem="G#other_name"><cons sem="G#protein_complex">NFkappaB</cons> activation</cons>, but not <cons sem="G#other_name"><cons sem="G#protein_complex">NFkappaB</cons> nuclear translocation</cons>.</sentence> > 6783c7553,7555 < Chronic <cons sem="G#other_name"><cons sem="G#virus">human immunodeficiency virus type 1</cons> infection</cons> of <cons sem="G#cell_type">myeloid cells</cons> disrupts the <cons sem="G#other_name">autoregulatory control</cons> of the <cons sem="G#other_name"><cons sem="G#protein_complex">NF-kappaB/Rel</cons> pathway</cons> via enhanced <cons sem="G#other_name"><cons sem="G#protein_molecule">IkappaBalpha</cons> degradation</cons>. --- > > <sentence>Chronic <cons sem="G#other_name"><cons sem="G#virus">human immunodeficiency virus type 1</cons> infection</cons> of <cons sem="G#cell_type">myeloid cells</cons> disrupts the <cons sem="G#other_name">autoregulatory control</cons> of the <cons sem="G#other_name"><cons sem="G#protein_complex">NF-kappaB/Rel</cons> pathway</cons> via enhanced <cons sem="G#other_name"><cons sem="G#protein_molecule">IkappaBalpha</cons> degradation</cons>.</sentence> > 6789,6792c7561,7564 < Constitutive PKR activity was also detected in HIV-1-infected cells as a result of low-level IFN production, since the addition of anti-IFN- alpha/beta antibody to the cells decreased PKR expression. < Furthermore, the analysis of IkappaBalpha turnover demonstrated an increased degradation of IkappaBalpha in HIV-1-infected cells that may account for the constitutive DNA binding activity. < A dramatic increase in the intracellular levels of NF-kappaB subunits c-Rel and NF-kappaB2 p100 and a moderate increase in NF-kappaB2 p52 and RelA(p65) were detected in HIV-1-infected cells, whereas NF-kappaB1 p105/p50 levels were not altered relative to the levels in uninfected cells. < We suggest that HIV- 1 infection of myeloid cells induces IFN production and PKR activity, which in turn contribute to enhanced IkappaBalpha phosphorylation and subsequent degradation. --- > Constitutive PKR activity was also detected in HIV-1-infected cells as a result of low-level IFN production, since the addition of anti-IFN- alpha/beta antibody to the cells decreased PKR expression. > Furthermore, the analysis of IkappaBalpha turnover demonstrated an increased degradation of IkappaBalpha in HIV-1-infected cells that may account for the constitutive DNA binding activity. > A dramatic increase in the intracellular levels of NF-kappaB subunits c-Rel and NF-kappaB2 p100 and a moderate increase in NF-kappaB2 p52 and RelA(p65) were detected in HIV-1-infected cells, whereas NF-kappaB1 p105/p50 levels were not altered relative to the levels in uninfected cells. > We suggest that HIV- 1 infection of myeloid cells induces IFN production and PKR activity, which in turn contribute to enhanced IkappaBalpha phosphorylation and subsequent degradation. 6802c7574,7576 < The <cons sem="G#protein_domain_or_region"><cons sem="G#protein_molecule">c-Jun</cons> delta-domain</cons> inhibits <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">neuroendocrine promoter</cons> activity</cons> in a <cons sem="(AND G#other_name G#other_name)"><cons>DNA sequence-</cons> and <cons>pituitary-</cons><cons>specific manner</cons></cons>. --- > > <sentence>The <cons sem="G#protein_domain_or_region"><cons sem="G#protein_molecule">c-Jun</cons> delta-domain</cons> inhibits <cons sem="G#other_name"><cons sem="G#DNA_domain_or_region">neuroendocrine promoter</cons> activity</cons> in a <cons sem="(AND G#other_name G#other_name)"><cons>DNA sequence-</cons> and <cons>pituitary-</cons><cons>specific manner</cons></cons>.</sentence> > 6818c7592,7594 < <cons sem="G#other_organic_compound">Retinoic acid</cons> activates <cons sem="G#other_name"><cons sem="G#protein_molecule">interferon regulatory factor-1</cons> gene expression</cons> in <cons sem="G#cell_type">myeloid cells</cons>. --- > > <sentence><cons sem="G#other_organic_compound">Retinoic acid</cons> activates <cons sem="G#other_name"><cons sem="G#protein_molecule">interferon regulatory factor-1</cons> gene expression</cons> in <cons sem="G#cell_type">myeloid cells</cons>.</sentence> > 6837c7613,7615 < Recombinant <cons sem="G#protein_molecule">NFAT1</cons> (NFATp) is regulated by calcineurin in <cons sem="G#cell_type">T cells</cons> and mediates transcription of several <cons sem="G#DNA_family_or_group">cytokine genes</cons>. --- > > <sentence>Recombinant <cons sem="G#protein_molecule">NFAT1</cons> (NFATp) is regulated by calcineurin in <cons sem="G#cell_type">T cells</cons> and mediates transcription of several <cons sem="G#DNA_family_or_group">cytokine genes</cons>.</sentence> > 6853c7631,7633 < <cons sem="G#protein_subunit">Human TAFII 105</cons> is a <cons sem="G#protein_subunit">cell type-specific <cons sem="G#protein_complex">TFIID</cons> subunit</cons> related to <cons sem="G#protein_molecule">hTAFII130</cons>. --- > > <sentence><cons sem="G#protein_subunit">Human TAFII 105</cons> is a <cons sem="G#protein_subunit">cell type-specific <cons sem="G#protein_complex">TFIID</cons> subunit</cons> related to <cons sem="G#protein_molecule">hTAFII130</cons>.</sentence> > 6868c7648,7650 < Interstitial deletion constitutes the major mechanism for loss of heterozygosity on <cons sem="G#DNA_molecule">chromosome 20q</cons> in <cons sem="G#other_name">polycythemia vera</cons>. --- > > <sentence>Interstitial deletion constitutes the major mechanism for loss of heterozygosity on <cons sem="G#DNA_molecule">chromosome 20q</cons> in <cons sem="G#other_name">polycythemia vera</cons>.</sentence> > 6881c7663 < Therefore, the human androgen receptor assay (HUMARA) was used to determine granulocyte clonality. --- > Therefore, the human androgen receptor assay (HUMARA) was used to determine granulocyte clonality. 6893c7675,7677 < <cons sem="G#protein_molecule">Interleukin-6</cons> promotes multiple myeloma cell growth via <cons sem="G#other_name">phosphorylation</cons> of <cons sem="G#protein_family_or_group">retinoblastoma protein</cons>. --- > > <sentence><cons sem="G#protein_molecule">Interleukin-6</cons> promotes multiple myeloma cell growth via <cons sem="G#other_name">phosphorylation</cons> of <cons sem="G#protein_family_or_group">retinoblastoma protein</cons>.</sentence> > 6911c7695,7697 < <cons sem="G#protein_family_or_group">Soluble factors</cons> secreted by <cons sem="G#cell_type">activated T-lymphocytes</cons> modulate the transcription of the <cons sem="G#protein_family_or_group">immunosuppressive cytokine</cons> <cons sem="G#protein_molecule">TGF-beta 2</cons> in <cons sem="G#cell_type">glial cells</cons>. --- > > <sentence><cons sem="G#protein_family_or_group">Soluble factors</cons> secreted by <cons sem="G#cell_type">activated T-lymphocytes</cons> modulate the transcription of the <cons sem="G#protein_family_or_group">immunosuppressive cytokine</cons> <cons sem="G#protein_molecule">TGF-beta 2</cons> in <cons sem="G#cell_type">glial cells</cons>.</sentence> > 6927c7713,7715 < Various modes of <cons sem="G#other_name"><cons sem="G#protein_family_or_group">basic helix-loop-helix protein</cons>-mediated regulation</cons> of <cons sem="G#other_name"><cons sem="G#virus">murine leukemia virus</cons> transcription</cons> in <cons sem="G#cell_line">lymphoid cell lines</cons>. --- > > <sentence>Various modes of <cons sem="G#other_name"><cons sem="G#protein_family_or_group">basic helix-loop-helix protein</cons>-mediated regulation</cons> of <cons sem="G#other_name"><cons sem="G#virus">murine leukemia virus</cons> transcription</cons> in <cons sem="G#cell_line">lymphoid cell lines</cons>.</sentence> > 6932c7720 < In lymphoid cell lines only, the E(gre)-binding protein complexes included ALF1 or HEB and E2A basic helix-loop-helix proteins. --- > In lymphoid cell lines only, the E(gre)-binding protein complexes included ALF1 or HEB and E2A basic helix-loop-helix proteins. 6936c7724 < In contrast, neither E(gre) nor EA/S motifs contributed pronouncedly to Akv MLV transcription in NIH 3T3 cells lacking DNA-binding ALF1 or HEB and E2A proteins. --- > In contrast, neither E(gre) nor EA/S motifs contributed pronouncedly to Akv MLV transcription in NIH 3T3 cells lacking DNA-binding ALF1 or HEB and E2A proteins. 6939c7727 < In conclusion, E(gre) motifs and interacting basic helix-loop-helix proteins are important determinants for MLV transcriptional activity in lymphocytic cell lines. --- > In conclusion, E(gre) motifs and interacting basic helix-loop-helix proteins are important determinants for MLV transcriptional activity in lymphocytic cell lines. 6947c7735,7737 < Reversal of <cons sem="G#other_name">apoptosis</cons> by the leukaemia-associated <cons sem="G#protein_molecule">E2A-HLF chimaeric <cons sem="G#protein_family_or_group">transcription factor</cons></cons>. --- > > <sentence>Reversal of <cons sem="G#other_name">apoptosis</cons> by the leukaemia-associated <cons sem="G#protein_molecule">E2A-HLF chimaeric <cons sem="G#protein_family_or_group">transcription factor</cons></cons>.</sentence> > 6960c7750,7752 < The role of <cons sem="G#DNA_domain_or_region">early growth response gene 1</cons> (<cons sem="G#DNA_domain_or_region">egr-1</cons>) in regulation of the <cons sem="G#other_name">immune response</cons>. --- > > <sentence>The role of <cons sem="G#DNA_domain_or_region">early growth response gene 1</cons> (<cons sem="G#DNA_domain_or_region">egr-1</cons>) in regulation of the <cons sem="G#other_name">immune response</cons>.</sentence> > 6976c7768,7770 < <cons sem="G#other_name"><cons sem="G#peptide">Peptide</cons> vaccination</cons> can lead to <cons sem="G#other_name">enhanced tumor growth</cons> through specific <cons sem="G#other_name">T-cell tolerance induction</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#peptide">Peptide</cons> vaccination</cons> can lead to <cons sem="G#other_name">enhanced tumor growth</cons> through specific <cons sem="G#other_name">T-cell tolerance induction</cons>.</sentence> > 6981c7775 < Ad5E1A-specific CTL activity could no longer be isolated from mice after injection of Ad5E1A-peptide, indicating that tolerization of Ad5E1A-specific CTL activity causes the enhanced tumor outgrowth. --- > Ad5E1A-specific CTL activity could no longer be isolated from mice after injection of Ad5E1A-peptide, indicating that tolerization of Ad5E1A-specific CTL activity causes the enhanced tumor outgrowth. 6992c7786,7788 < [<cons sem="G#protein_family_or_group">NGFI-B/nur77 family</cons> involved in <cons sem="G#other_name">T-cell <cons sem="G#other_name">apoptosis</cons></cons>] --- > > <sentence>[<cons sem="G#protein_family_or_group">NGFI-B/nur77 family</cons> involved in <cons sem="G#other_name">T-cell <cons sem="G#other_name">apoptosis</cons></cons>]</sentence> > 7007c7803,7805 < <cons sem="G#lipid">Glucocorticoids</cons> and <cons sem="G#protein_molecule">interferon-alpha</cons> in the <cons sem="G#other_name">acquired immunodeficiency syndrome</cons>. --- > > <sentence><cons sem="G#lipid">Glucocorticoids</cons> and <cons sem="G#protein_molecule">interferon-alpha</cons> in the <cons sem="G#other_name">acquired immunodeficiency syndrome</cons>.</sentence> > 7017c7815 < By contrast, glucocorticoids failed to inhibit IFNalpha production from AIDS-GR monocytes (approximately 20% inhibition). --- > By contrast, glucocorticoids failed to inhibit IFNalpha production from AIDS-GR monocytes (approximately 20% inhibition). 7026c7824,7826 < <cons sem="G#protein_molecule">JNK</cons> (<cons sem="G#protein_molecule">c-Jun NH2-terminal kinase</cons>) is a target for <cons sem="G#other_organic_compound">antioxidants</cons> in <cons sem="G#cell_type">T lymphocytes</cons>. --- > > <sentence><cons sem="G#protein_molecule">JNK</cons> (<cons sem="G#protein_molecule">c-Jun NH2-terminal kinase</cons>) is a target for <cons sem="G#other_organic_compound">antioxidants</cons> in <cons sem="G#cell_type">T lymphocytes</cons>.</sentence> > 7045c7845,7847 < [Molecular mechanisms of <cons sem="G#other_name">age-related lymphocyte dysfunction</cons>] --- > > <sentence>[Molecular mechanisms of <cons sem="G#other_name">age-related lymphocyte dysfunction</cons>]</sentence> > 7064c7866,7868 < Induction of <cons sem="G#other_name">bcl-2 expression</cons> by phosphorylated CREB proteins during B- cell activation and rescue from apoptosis. --- > > <sentence>Induction of <cons sem="G#other_name"><cons sem="G#protein_molecule">bcl-2</cons> expression</cons> by phosphorylated CREB proteins during B- cell activation and rescue from apoptosis.</sentence> > 7068c7872 < We have located the major positive regulatory region for control of bcl-2 expression in B cells in the 5'-flanking region. --- > We have located the major positive regulatory region for control of bcl-2 expression in B cells in the 5'-flanking region. 7073,7074c7877,7878 < The presence of an active CRE site in the bcl-2 promoter implies that the regulation of bcl-2 expression is linked to a signal transduction pathway in B cells. < Treatment of the mature B-cell line BAL-17 with either anti-immunoglobulin M or phorbol 12-myristate 13-acetate leads to an increase in bcl-2 expression that is mediated by the CRE site. --- > The presence of an active CRE site in the bcl-2 promoter implies that the regulation of bcl-2 expression is linked to a signal transduction pathway in B cells. > Treatment of the mature B-cell line BAL-17 with either anti-immunoglobulin M or phorbol 12-myristate 13-acetate leads to an increase in bcl-2 expression that is mediated by the CRE site. 7076c7880 < bcl-2 expression is increased following phorbol ester treatment, and the increased expression is dependent on the CRE site. --- > bcl-2 expression is increased following phorbol ester treatment, and the increased expression is dependent on the CRE site. 7079,7081c7883,7885 < Although the CRE site is necessary, optimal induction of bcl-2 expression requires participation of the upstream regulatory element, suggesting that phosphorylation of CREB alters its interaction with the upstream regulatory element. < The CRE site in the bcl-2 promoter appears to play a major role in the induction of bcl-2 expression during the activation of mature B cells and during the rescue of immature B cells from apoptosis. < It is possible that the CRE site is responsible for induction of bcl-2 expression in other cell types, particularly those in which protein kinase C is involved. --- > Although the CRE site is necessary, optimal induction of bcl-2 expression requires participation of the upstream regulatory element, suggesting that phosphorylation of CREB alters its interaction with the upstream regulatory element. > The CRE site in the bcl-2 promoter appears to play a major role in the induction of bcl-2 expression during the activation of mature B cells and during the rescue of immature B cells from apoptosis. > It is possible that the CRE site is responsible for induction of bcl-2 expression in other cell types, particularly those in which protein kinase C is involved. 7089c7893,7895 < Characterization of the <cons sem="G#DNA_domain_or_region"><cons sem="G#other_name">human myeloid cell nuclear differentiation</cons> antigen gene promoter</cons>. --- > > <sentence>Characterization of the <cons sem="G#DNA_domain_or_region"><cons sem="G#other_name">human myeloid cell nuclear differentiation</cons> antigen gene promoter</cons>.</sentence> > 7105c7911,7913 < Abnormality of <cons sem="G#other_name"><cons sem="G#protein_molecule">Oct-1</cons> DNA binding</cons> in <cons sem="G#cell_type">T cells</cons> from <cons sem="G#multi_cell"><cons sem="G#other_name">Sjogren's syndrome</cons> patients</cons>. --- > > <sentence>Abnormality of <cons sem="G#other_name"><cons sem="G#protein_molecule">Oct-1</cons> DNA binding</cons> in <cons sem="G#cell_type">T cells</cons> from <cons sem="G#multi_cell"><cons sem="G#other_name">Sjogren's syndrome</cons> patients</cons>.</sentence> > 7122c7930,7932 < Characterization of a new isoform of the <cons sem="G#protein_family_or_group">NFAT</cons> (<cons sem="G#protein_family_or_group">nuclear factor of activated T cells</cons>) gene family member <cons sem="G#protein_molecule">NFATc</cons> [published erratum appears in J Biol Chem 1996 Dec 27;271(52):33705] --- > > <sentence>Characterization of a new isoform of the <cons sem="G#protein_family_or_group">NFAT</cons> (<cons sem="G#protein_family_or_group">nuclear factor of activated T cells</cons>) gene family member <cons sem="G#protein_molecule">NFATc</cons> [published erratum appears in J Biol Chem 1996 Dec 27;271(52):33705]</sentence> > 7141c7951,7953 < Regulation of <cons sem="G#protein_molecule">interferon-gamma</cons> <cons sem="G#other_name">gene expression</cons>. --- > > <sentence>Regulation of <cons sem="G#protein_molecule">interferon-gamma</cons> <cons sem="G#other_name">gene expression</cons>.</sentence> > 7154c7966,7968 < Transcriptional analysis of <cons sem="G#virus">Epstein-Barr virus</cons> <cons sem="G#other_name">gene expression</cons> in <cons sem="G#tissue">EBV- positive gastric carcinoma</cons>: unique <cons sem="G#other_name">viral latency</cons> in the <cons sem="G#cell_type">tumour cells</cons>. --- > > <sentence>Transcriptional analysis of <cons sem="G#virus">Epstein-Barr virus</cons> <cons sem="G#other_name">gene expression</cons> in <cons sem="G#tissue">EBV- positive gastric carcinoma</cons>: unique <cons sem="G#other_name">viral latency</cons> in the <cons sem="G#cell_type">tumour cells</cons>.</sentence> > 7171c7985,7987 < Characterization of <cons sem="G#protein_family_or_group">Grb2-binding proteins</cons> in <cons sem="G#cell_type">human platelets</cons> activated by <cons sem="G#other_name">Fc gamma RIIA cross-linking</cons>. --- > > <sentence>Characterization of <cons sem="G#protein_family_or_group">Grb2-binding proteins</cons> in <cons sem="G#cell_type">human platelets</cons> activated by <cons sem="G#other_name"><cons sem="G#protein_molecule">Fc gamma RIIA</cons> cross-linking</cons>.</sentence> > 7179c7995 < Tyrosine phosphorylation of p38 and p63 is also observed in platelets stimulated by the tyrosine kinase-linked receptor agonist collagen and by the G protein-coupled receptor agonist thrombin, although phosphorylation of SLP-76 is only observed in collagen-stimulated platelets. --- > Tyrosine phosphorylation of p38 and p63 is also observed in platelets stimulated by the tyrosine kinase-linked receptor agonist collagen and by the G protein-coupled receptor agonist thrombin, although phosphorylation of SLP-76 is only observed in collagen-stimulated platelets. 7188c8004,8006 < <cons sem="G#other_name">Constitutive expression</cons> of specific <cons sem="G#protein_family_or_group">interferon isotypes</cons> in <cons sem="G#cell_type">peripheral blood leukocytes</cons> from <cons sem="G#multi_cell">normal individuals</cons> and in <cons sem="G#cell_line">promonocytic U937 cells</cons>. --- > > <sentence><cons sem="G#other_name">Constitutive expression</cons> of specific <cons sem="G#protein_family_or_group">interferon isotypes</cons> in <cons sem="G#cell_type">peripheral blood leukocytes</cons> from <cons sem="G#multi_cell">normal individuals</cons> and in <cons sem="G#cell_line">promonocytic U937 cells</cons>.</sentence> > 7190c8008 < Constitutive expression of IFN-alpha5 and IFN-beta was detected in different lymphoid cells including peripheral blood mononuclear cells from normal individuals following amplification of IFN mRNA by reverse transcriptase-polymerase chain reaction and direct sequencing of the amplified product. --- > Constitutive expression of IFN-alpha5 and IFN-beta was detected in different lymphoid cells including peripheral blood mononuclear cells from normal individuals following amplification of IFN mRNA by reverse transcriptase-polymerase chain reaction and direct sequencing of the amplified product. 7202c8020,8022 < An <cons sem="G#DNA_domain_or_region">IL-2 response element</cons> in the <cons sem="G#DNA_domain_or_region">human IL-2 receptor alpha chain promoter</cons> is a <cons sem="G#DNA_family_or_group">composite element</cons> that binds <cons sem="G#protein_molecule">Stat5</cons>, <cons sem="G#protein_molecule">Elf-1</cons>, <cons sem="G#protein_molecule">HMG-I(Y</cons>) and a <cons sem="G#protein_family_or_group">GATA family protein</cons>. --- > > <sentence>An <cons sem="G#DNA_domain_or_region">IL-2 response element</cons> in the <cons sem="G#DNA_domain_or_region">human IL-2 receptor alpha chain promoter</cons> is a <cons sem="G#DNA_family_or_group">composite element</cons> that binds <cons sem="G#protein_molecule">Stat5</cons>, <cons sem="G#protein_molecule">Elf-1</cons>, <cons sem="G#protein_molecule">HMG-I(Y</cons>) and a <cons sem="G#protein_family_or_group">GATA family protein</cons>.</sentence> > 7207,7208c8027,8028 < Multiple factors including Stat5, Elf-1, HMG-I(Y) and GATA family proteins bind to the IL-2 response element and mutation of any one of these binding sites diminishes the activity of this element. < An unidentified Ets family protein binds to the EBS overlapping the consensus GAS motif and appears to negatively regulate the human IL-2R alpha promoter. --- > Multiple factors including Stat5, Elf-1, HMG-I(Y) and GATA family proteins bind to the IL-2 response element and mutation of any one of these binding sites diminishes the activity of this element. > An unidentified Ets family protein binds to the EBS overlapping the consensus GAS motif and appears to negatively regulate the human IL-2R alpha promoter. 7217c8037,8039 < <cons sem="G#cell_type">Lymphocytes</cons> from <cons sem="G#multi_cell">CML patients</cons> lack a <cons sem="G#protein_molecule">47 kDa factor</cons> having affinity for a <cons sem="G#DNA_domain_or_region">genomic sterol regulatory sequence</cons>. --- > > <sentence><cons sem="G#cell_type">Lymphocytes</cons> from <cons sem="G#multi_cell">CML patients</cons> lack a <cons sem="G#protein_molecule">47 kDa factor</cons> having affinity for a <cons sem="G#DNA_domain_or_region">genomic sterol regulatory sequence</cons>.</sentence> > 7221c8043 < However, this factor appeared when these CML patients achieved complete haematological remission (CHR) through alpha-interferon therapy. --- > However, this factor appeared when these CML patients achieved complete haematological remission (CHR) through alpha-interferon therapy. 7231c8053,8055 < Cloning and characterization of the <cons sem="G#protein_subunit">beta subunit</cons> of <cons sem="G#protein_complex"><cons sem="G#DNA_domain_or_region">human proximal sequence element</cons>-binding transcription factor</cons> and its involvement in transcription of <cons sem="G#DNA_family_or_group">small nuclear RNA genes</cons> by <cons sem="(AND G#protein_molecule G#protein_molecule)"><cons>RNA polymerases</cons> <cons>II</cons> and <cons>III</cons></cons>. --- > > <sentence>Cloning and characterization of the <cons sem="G#protein_subunit">beta subunit</cons> of <cons sem="G#protein_complex"><cons sem="G#DNA_domain_or_region">human proximal sequence element</cons>-binding transcription factor</cons> and its involvement in transcription of <cons sem="G#DNA_family_or_group">small nuclear RNA genes</cons> by <cons sem="(AND G#protein_molecule G#protein_molecule)"><cons>RNA polymerases</cons> <cons>II</cons> and <cons>III</cons></cons>.</sentence> > 7247c8071,8073 < Attenuated function of a variant form of the <cons sem="G#protein_family_or_group">helix-loop-helix protein</cons>, <cons sem="G#protein_molecule">Id-3</cons>, generated by an alternative splicing mechanism. --- > > <sentence>Attenuated function of a variant form of the <cons sem="G#protein_family_or_group">helix-loop-helix protein</cons>, <cons sem="G#protein_molecule">Id-3</cons>, generated by an alternative splicing mechanism.</sentence> > 7260c8086,8088 < <cons sem="G#other_organic_compound">Tyloxapol</cons> inhibits <cons sem="G#protein_complex">NF-kappa B</cons> and <cons sem="G#other_name"><cons sem="G#protein_family_or_group">cytokine</cons> release</cons>, scavenges <cons sem="G#protein_molecule">HOCI</cons>, and reduces viscosity of <cons sem="G#other_name">cystic fibrosis sputum</cons>. --- > > <sentence><cons sem="G#other_organic_compound">Tyloxapol</cons> inhibits <cons sem="G#protein_complex">NF-kappa B</cons> and <cons sem="G#other_name"><cons sem="G#protein_family_or_group">cytokine</cons> release</cons>, scavenges <cons sem="G#protein_molecule">HOCI</cons>, and reduces viscosity of <cons sem="G#other_name">cystic fibrosis sputum</cons>.</sentence> > 7262c8090 < Cystic fibrosis (CF) patients develop progressive cytokine-mediated inflammatory lung disease, with abundant production of thick, tenacious, protease- and oxidant-rich purulent airway secretions that are difficult to clear even with physiotherapy. --- > Cystic fibrosis (CF) patients develop progressive cytokine-mediated inflammatory lung disease, with abundant production of thick, tenacious, protease- and oxidant-rich purulent airway secretions that are difficult to clear even with physiotherapy. 7276c8104,8106 < Elevated <cons sem="G#nucleotide">cyclic AMP</cons> inhibits <cons sem="G#other_name"><cons sem="G#protein_complex">NF-kappaB</cons>-mediated transcription</cons> in human monocytic cells and endothelial cells. --- > > <sentence>Elevated <cons sem="G#nucleotide">cyclic AMP</cons> inhibits <cons sem="G#other_name"><cons sem="G#protein_complex">NF-kappaB</cons>-mediated transcription</cons> in human monocytic cells and endothelial cells.</sentence> > 7281c8111 < Induction of NF- kappaB-dependent gene expression in transiently transfected human monocytic THP-1 cells and human umbilical vein endothelial cells was inhibited by elevated cAMP and by overexpression of the catalytic subunit of protein kinase A (PKA). --- > Induction of NF- kappaB-dependent gene expression in transiently transfected human monocytic THP-1 cells and human umbilical vein endothelial cells was inhibited by elevated cAMP and by overexpression of the catalytic subunit of protein kinase A (PKA). 7292c8122,8124 < <cons sem="G#other_name">Molecular mechanisms</cons> of <cons sem="G#other_name">steroid action</cons>: a novel type of cross-talk between <cons sem="G#lipid">glucocorticoids</cons> and <cons sem="G#protein_complex">NF-kappa B</cons> <cons sem="G#protein_family_or_group">transcription factors</cons>. --- > > <sentence><cons sem="G#other_name">Molecular mechanisms</cons> of <cons sem="G#other_name">steroid action</cons>: a novel type of cross-talk between <cons sem="G#lipid">glucocorticoids</cons> and <cons sem="G#protein_complex">NF-kappa B</cons> <cons sem="G#protein_family_or_group">transcription factors</cons>.</sentence> > 7296c8128 < We observed that in a monocytic (U937) and a bronchial epithelial (H292) cell-line dexamethasone strongly suppressed basal and induced ICAM-1 expression. --- > We observed that in a monocytic (U937) and a bronchial epithelial (H292) cell-line dexamethasone strongly suppressed basal and induced ICAM-1 expression. 7307c8139,8141 < Abnormalities of <cons sem="(AND G#DNA_domain_or_region G#DNA_domain_or_region G#DNA_domain_or_region)"><cons>p16</cons>, <cons>p15</cons> and <cons>CDK4</cons> <cons>genes</cons></cons> in <cons sem="G#other_name">recurrent malignant astrocytomas</cons>. --- > > <sentence>Abnormalities of <cons sem="(AND G#DNA_domain_or_region G#DNA_domain_or_region G#DNA_domain_or_region)"><cons>p16</cons>, <cons>p15</cons> and <cons>CDK4</cons> <cons>genes</cons></cons> in <cons sem="G#other_name">recurrent malignant astrocytomas</cons>.</sentence> > 7323c8157,8159 < <cons sem="G#protein_molecule">BCL-6</cons>, a <cons sem="G#protein_family_or_group">POZ/zinc-finger protein</cons>, is a <cons sem="G#protein_family_or_group">sequence-specific transcriptional repressor</cons>. --- > > <sentence><cons sem="G#protein_molecule">BCL-6</cons>, a <cons sem="G#protein_family_or_group">POZ/zinc-finger protein</cons>, is a <cons sem="G#protein_family_or_group">sequence-specific transcriptional repressor</cons>.</sentence> > 7338c8174,8176 < Signals leading to the activation of <cons sem="G#protein_complex"><cons sem="G#protein_complex">NF-kappa B</cons> transcription factor</cons> are stronger in <cons sem="(THAN G#cell_type G#cell_type)"><cons>neonatal</cons> than <cons>adult</cons> <cons>T lymphocytes</cons></cons>. --- > > <sentence>Signals leading to the activation of <cons sem="G#protein_complex"><cons sem="G#protein_complex">NF-kappa B</cons> transcription factor</cons> are stronger in <cons sem="(THAN G#cell_type G#cell_type)"><cons>neonatal</cons> than <cons>adult</cons> <cons>T lymphocytes</cons></cons>.</sentence> > 7354c8192,8194 < Dual action of <cons sem="G#other_organic_compound">retinoic acid</cons> on <cons sem="G#other_name">human embryonic/fetal hematopoiesis</cons>: blockade of <cons sem="G#other_name">primitive progenitor proliferation</cons> and shift from <cons sem="G#other_name">multipotent/erythroid/monocytic</cons> to <cons sem="G#other_name">granulocytic differentiation program</cons>. --- > > <sentence>Dual action of <cons sem="G#other_organic_compound">retinoic acid</cons> on <cons sem="G#other_name">human embryonic/fetal hematopoiesis</cons>: blockade of <cons sem="G#other_name">primitive progenitor proliferation</cons> and shift from <cons sem="G#other_name">multipotent/erythroid/monocytic</cons> to <cons sem="G#other_name">granulocytic differentiation program</cons>.</sentence> > 7373c8213,8215 < <cons sem="G#other_name"><cons sem="G#lipid">Dexamethasone</cons> suppression</cons> test: <cons sem="G#protein_family_or_group">corticosteroid receptors</cons> regulation in <cons sem="G#cell_type">mononuclear leukocytes</cons> of <cons sem="(AND G#multi_cell G#multi_cell)"><cons>young</cons> and <cons>aged</cons> <cons>subjects</cons></cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#lipid">Dexamethasone</cons> suppression</cons> test: <cons sem="G#protein_family_or_group">corticosteroid receptors</cons> regulation in <cons sem="G#cell_type">mononuclear leukocytes</cons> of <cons sem="(AND G#multi_cell G#multi_cell)"><cons>young</cons> and <cons>aged</cons> <cons>subjects</cons></cons>.</sentence> > 7392c8234,8236 < Analysis of the <cons sem="G#protein_domain_or_region">ligand-binding domain</cons> of <cons sem="G#protein_molecule">human retinoic acid receptor alpha</cons> by <cons sem="G#other_name">site-directed mutagenesis</cons>. --- > > <sentence>Analysis of the <cons sem="G#protein_domain_or_region">ligand-binding domain</cons> of <cons sem="G#protein_molecule">human retinoic acid receptor alpha</cons> by <cons sem="G#other_name">site-directed mutagenesis</cons>.</sentence> > 7398c8242 < All conserved cysteine and arginine residues in this domain were mutated by site- directed mutagenesis, and the mutant proteins were characterized by blocking reactions, ligand-binding experiments, transactivation assays, and protease mapping. --- > All conserved cysteine and arginine residues in this domain were mutated by site- directed mutagenesis, and the mutant proteins were characterized by blocking reactions, ligand-binding experiments, transactivation assays, and protease mapping. 7413c8257,8259 < <cons sem="(AND G#protein_molecule G#protein_molecule)"><cons>IL4</cons> and <cons>IL13</cons> <cons>receptors</cons></cons> share the <cons sem="G#protein_subunit">gamma c chain</cons> and activate <cons sem="(AND G#protein_molecule G#protein_molecule G#protein_molecule)"><cons>STAT6</cons>, <cons>STAT3</cons> and <cons>STAT5</cons> <cons>proteins</cons></cons> in <cons sem="G#cell_type">normal human B cells</cons>. --- > > <sentence><cons sem="(AND G#protein_molecule G#protein_molecule)"><cons>IL4</cons> and <cons>IL13</cons> <cons>receptors</cons></cons> share the <cons sem="G#protein_subunit">gamma c chain</cons> and activate <cons sem="(AND G#protein_molecule G#protein_molecule G#protein_molecule)"><cons>STAT6</cons>, <cons>STAT3</cons> and <cons>STAT5</cons> <cons>proteins</cons></cons> in <cons sem="G#cell_type">normal human B cells</cons>.</sentence> > 7425c8271,8273 < <cons sem="G#protein_molecule">Calcineurin mutants</cons> render <cons sem="G#cell_type">T lymphocytes</cons> resistant to <cons sem="G#other_organic_compound">cyclosporin A</cons>. --- > > <sentence><cons sem="G#protein_molecule">Calcineurin mutants</cons> render <cons sem="G#cell_type">T lymphocytes</cons> resistant to <cons sem="G#other_organic_compound">cyclosporin A</cons>.</sentence> > 7431c8279 < In this report, we demonstrate that the corresponding mutations in murine calcineurin render the T cell receptor signal transduction cascade CsA resistant in human Jurkat T cells. --- > In this report, we demonstrate that the corresponding mutations in murine calcineurin render the T cell receptor signal transduction cascade CsA resistant in human Jurkat T cells. 7440c8288,8290 < <cons sem="G#other_name">Epstein-Barr viral latency</cons> is disrupted by the <cons sem="G#protein_molecule">immediate-early BRLF1 protein</cons> through a <cons sem="G#other_name">cell-specific mechanism</cons>. --- > > <sentence><cons sem="G#other_name">Epstein-Barr viral latency</cons> is disrupted by the <cons sem="G#protein_molecule">immediate-early BRLF1 protein</cons> through a <cons sem="G#other_name">cell-specific mechanism</cons>.</sentence> > 7444c8294 < Epithelial cells are the major site of lytic EBV replication within the human host, and viral reactivation occurs in EBV- associated nasopharyngeal carcinomas. --- > Epithelial cells are the major site of lytic EBV replication within the human host, and viral reactivation occurs in EBV- associated nasopharyngeal carcinomas. 7456c8306,8308 < <cons sem="G#other_name"><cons sem="G#cell_type">Eosinophil</cons> priming</cons> by <cons sem="G#protein_family_or_group">cytokines</cons>: from <cons sem="G#other_name">cellular signal</cons> to <cons sem="G#other_name">in vivo modulation</cons>. --- > > <sentence><cons sem="G#other_name"><cons sem="G#cell_type">Eosinophil</cons> priming</cons> by <cons sem="G#protein_family_or_group">cytokines</cons>: from <cons sem="G#other_name">cellular signal</cons> to <cons sem="G#other_name">in vivo modulation</cons>.</sentence> > 7468,7469c8320,8323 < <cons sem="G#other_name">CTL recognition</cons> of an <cons sem="G#peptide">altered peptide</cons> associated with <cons sem="G#other_name"><cons sem="G#amino_acid_monomer">asparagine</cons> bond rearrangement</cons>. < Implications for <cons sem="G#other_name">immunity</cons> and <cons sem="G#other_name">vaccine design</cons>. --- > > <sentence><cons sem="G#other_name">CTL recognition</cons> of an <cons sem="G#peptide">altered peptide</cons> associated with <cons sem="G#other_name"><cons sem="G#amino_acid_monomer">asparagine</cons> bond rearrangement</cons>.</sentence> > <sentence>Implications for <cons sem="G#other_name">immunity</cons> and <cons sem="G#other_name">vaccine design</cons>.</sentence> > 7486c8340,8342 < A 3' --> 5' <cons sem="G#other_name"><cons sem="G#protein_family_or_group">XPB helicase</cons> defect</cons> in <cons sem="G#protein_family_or_group">repair/transcription factor</cons> <cons sem="G#protein_molecule">TFIIH</cons> of xeroderma pigmentosum group B affects both <cons sem="G#other_name">DNA repair</cons> and <cons sem="G#other_name">transcription</cons>. --- > > <sentence>A 3' --> 5' <cons sem="G#other_name"><cons sem="G#protein_family_or_group">XPB helicase</cons> defect</cons> in <cons sem="G#protein_family_or_group">repair/transcription factor</cons> <cons sem="G#protein_molecule">TFIIH</cons> of xeroderma pigmentosum group B affects both <cons sem="G#other_name">DNA repair</cons> and <cons sem="G#other_name">transcription</cons>.</sentence> > 7494c8350 < In addition, we provide evidence for a decrease in basal transcription activity in vitro. --- > In addition, we provide evidence for a decrease in basal transcription activity in vitro. 7504c8360,8362 < The Ets protein <cons sem="G#protein_molecule">Spi-B</cons> is expressed exclusively in <cons sem="G#cell_type">B cells</cons> and <cons sem="G#cell_type">T cells</cons> during development. --- > > <sentence>The Ets protein <cons sem="G#protein_molecule">Spi-B</cons> is expressed exclusively in <cons sem="G#cell_type">B cells</cons> and <cons sem="G#cell_type">T cells</cons> during development.</sentence> > 7524c8382,8384 < A critical role of <cons sem="(AND G#protein_family_or_group G#protein_family_or_group)"><cons>Sp1-</cons> and <cons>Ets-</cons><cons>related transcription factors</cons></cons> in maintaining <cons sem="G#other_name">CTL-specific expression</cons> of the <cons sem="G#DNA_domain_or_region">mouse perforin gene</cons>. --- > > <sentence>A critical role of <cons sem="(AND G#protein_family_or_group G#protein_family_or_group)"><cons>Sp1-</cons> and <cons>Ets-</cons><cons>related transcription factors</cons></cons> in maintaining <cons sem="G#other_name">CTL-specific expression</cons> of the <cons sem="G#DNA_domain_or_region">mouse perforin gene</cons>.</sentence> > 7544c8404,8406 < The <cons sem="G#protein_molecule">Oct-2 transcription factor</cons>. --- > > <sentence>The <cons sem="G#protein_molecule">Oct-2 transcription factor</cons>.</sentence> > 7557c8419,8421 < <cons sem="G#other_name">Cell-type-specific